2LBS
 
 | | Solution structure of double-stranded RNA binding domain of S. cerevisiae RNase III (Rnt1p) in complex with AAGU tetraloop hairpin | | 分子名称: | RNA (32-MER), Ribonuclease 3 | | 著者 | Wang, Z, Hartman, E, Roy, K, Chanfreau, G, Feigon, J. | | 登録日 | 2011-04-06 | | 公開日 | 2011-08-31 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of a Yeast RNase III dsRBD Complex with a Noncanonical RNA Substrate Provides New Insights into Binding Specificity of dsRBDs.
Structure, 19, 2011
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2LUP
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8JJ6
 | | Structure of the NELF-BCE complex | | 分子名称: | NELF-E, Negative elongation factor B, Negative elongation factor complex member C/D | | 著者 | Wang, Z, Cao, Y, Qin, Y. | | 登録日 | 2023-05-29 | | 公開日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.72 Å) | | 主引用文献 | The crystal structure of the human NELF-B, NELF-C, and NELF-E trimeric complex
To Be Published
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4KVC
 | | 2H2 Fab fragment of immature Dengue virus | | 分子名称: | Ig heavy chain V region MOPC 21, Igh protein, Ig kappa chain V-V region MOPC 21, ... | | 著者 | Wang, Z, Rossmann, M.G. | | 登録日 | 2013-05-22 | | 公開日 | 2013-07-24 | | 最終更新日 | 2017-08-02 | | 実験手法 | X-RAY DIFFRACTION (2.306 Å) | | 主引用文献 | Obstruction of Dengue Virus Maturation by Fab Fragments of the 2H2 Antibody.
J.Virol., 87, 2013
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4L9A
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6J71
 | | HuA21-scFv in complex with the extracellular domain(ECD) of HER2 | | 分子名称: | Receptor tyrosine-protein kinase erbB-2, anti-HER2 humanized antibody HuA21, beta-D-mannopyranose, ... | | 著者 | Wang, Z, Guo, G, Cheng, B, Zhu, Z, Niu, L, Zhang, H. | | 登録日 | 2019-01-16 | | 公開日 | 2019-02-27 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.918 Å) | | 主引用文献 | Structural insight into a matured humanized monoclonal antibody HuA21 against HER2-overexpressing cancer cells.
Acta Crystallogr D Struct Biol, 75, 2019
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6IIQ
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6IIT
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6IIR
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6IIP
 | | Apo-form structure of the HRP3 PWWP domain | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Hepatoma-derived growth factor-related protein 3, SULFATE ION | | 著者 | Wang, Z, Tian, W. | | 登録日 | 2018-10-07 | | 公開日 | 2019-04-24 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (0.951 Å) | | 主引用文献 | Apo-form structure of the HRP3 PWWP domain
Nucleic Acids Res., 2019
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6IIS
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5WK1
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4PSQ
 | | Crystal Structure of Retinol-Binding Protein 4 (RBP4) in complex with a non-retinoid ligand | | 分子名称: | (1-benzyl-1H-imidazol-4-yl)[4-(2-chlorophenyl)piperazin-1-yl]methanone, 1,2-ETHANEDIOL, PHOSPHATE ION, ... | | 著者 | Wang, Z, Johnstone, S, Walker, N. | | 登録日 | 2014-03-07 | | 公開日 | 2014-07-02 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structure-assisted discovery of the first non-retinoid ligands for Retinol-Binding Protein 4.
Bioorg.Med.Chem.Lett., 24, 2014
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3D5Q
 | | Crystal Structure of 11b-HSD1 in Complex with Triazole Inhibitor | | 分子名称: | 3-[1-(4-fluorophenyl)cyclopropyl]-4-(1-methylethyl)-5-[4-(trifluoromethoxy)phenyl]-4H-1,2,4-triazole, Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Wang, Z, Liu, J, Sudom, A, Walker, N.P.C. | | 登録日 | 2008-05-16 | | 公開日 | 2008-10-07 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Distinctive molecular inhibition mechanisms for selective inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1.
Bioorg.Med.Chem., 16, 2008
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3LYO
 | | CROSS-LINKED CHICKEN LYSOZYME CRYSTAL IN 95% ACETONITRILE-WATER | | 分子名称: | ACETONITRILE, LYSOZYME | | 著者 | Huang, Q, Wang, Z, Zhu, G, Qian, M, Shao, M, Jia, Y, Tang, Y. | | 登録日 | 1998-03-11 | | 公開日 | 1998-05-27 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | | 主引用文献 | X-ray studies on cross-linked lysozyme crystals in acetonitrile-water mixture.
Biochim.Biophys.Acta, 1384, 1998
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3VZD
 | | Crystal structure of Sphingosine Kinase 1 with inhibitor and ADP | | 分子名称: | 4-{[4-(4-chlorophenyl)-1,3-thiazol-2-yl]amino}phenol, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ... | | 著者 | Min, X, Walker, N.P, Wang, Z. | | 登録日 | 2012-10-11 | | 公開日 | 2013-05-01 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Molecular basis of sphingosine kinase 1 substrate recognition and catalysis.
Structure, 21, 2013
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6L6V
 | | SPO1 Gp44 N-terminal region (1-55) | | 分子名称: | E3 protein | | 著者 | Liu, B, Wang, Z. | | 登録日 | 2019-10-29 | | 公開日 | 2021-05-05 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | A Bacteriophage DNA Mimic Protein Employs a Non-specific Strategy to Inhibit the Bacterial RNA Polymerase.
Front Microbiol, 12, 2021
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5JJA
 | | Crystal structure of a PP2A B56gamma/BubR1 complex | | 分子名称: | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | | 著者 | Wang, Z, Wang, J, Rao, Z, Xu, W. | | 登録日 | 2016-04-22 | | 公開日 | 2016-07-13 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Crystal structure of a PP2A B56-BubR1 complex and its implications for PP2A substrate recruitment and localization.
Protein Cell, 7, 2016
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4FFW
 | | Crystal Structure of Dipeptidyl Peptidase IV (DPP4, DPP-IV, CD26) in Complex with Fab + sitagliptin | | 分子名称: | (2R)-4-OXO-4-[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-A MINE, Dipeptidyl peptidase 4, Fab heavy chain, ... | | 著者 | Wang, Z, Sudom, A, Walker, N.P, Min, X. | | 登録日 | 2012-06-01 | | 公開日 | 2012-12-12 | | 最終更新日 | 2021-05-19 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | An Inhibitory Antibody Against DPP IV Improves Glucose Tolerance in vivo - Validation of Large Molecule Approach for DPP IV Inhibition
To be published
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4FFV
 | | Crystal Structure of Dipeptidyl Peptidase IV (DPP4, DPP-IV, CD26) in Complex with 11A19 Fab | | 分子名称: | 11A19 Fab heavy chain, 11A19 Fab light chain, Dipeptidyl peptidase 4 | | 著者 | Wang, Z, Sudom, A, Walker, N.P, Min, X. | | 登録日 | 2012-06-01 | | 公開日 | 2012-12-12 | | 最終更新日 | 2021-05-19 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | An Inhibitory Antibody Against DPP IV Improves Glucose Tolerance in vivo - Validation of Large Molecule Approach for DPP IV Inhibition
To be published
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6EF4
 | | Crystal structure of mouse PP2A Aalpha P179R mutant | | 分子名称: | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform | | 著者 | Wang, Z, Shen, G, Xu, W. | | 登録日 | 2018-08-16 | | 公開日 | 2019-06-26 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | The Highly Recurrent PP2A A alpha-Subunit Mutation P179R Alters Protein Structure and Impairs PP2A Enzyme Function to Promote Endometrial Tumorigenesis.
Cancer Res., 79, 2019
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5UFL
 | | Crystal structure of a CIP2A core domain | | 分子名称: | Protein CIP2A, ZINC ION | | 著者 | Wang, Z, Wang, J, Rao, Z, Xu, W. | | 登録日 | 2017-01-04 | | 公開日 | 2017-02-15 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Oncoprotein CIP2A is stabilized via interaction with tumor suppressor PP2A/B56.
EMBO Rep., 18, 2017
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3GL6
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3FMZ
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4O9S
 | | Crystal structure of Retinol-Binding Protein 4 (RBP4)in complex with a non-retinoid ligand | | 分子名称: | 1,2-ETHANEDIOL, 1-[4-(7-thia-9,11-diazatricyclo[6.4.0.0^{2,6}]dodeca-1(12),2(6),8,10-tetraen-12-yl)piperazin-1-yl]-2-[2-(trifluoromethyl)phenyl]ethanone, CHLORIDE ION, ... | | 著者 | Wang, Z, Johnstone, S, Walker, N.P. | | 登録日 | 2014-01-02 | | 公開日 | 2014-07-02 | | 最終更新日 | 2020-02-19 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structure-assisted discovery of the first non-retinoid ligands for Retinol-Binding Protein 4.
Bioorg.Med.Chem.Lett., 24, 2014
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