6J71

HuA21-scFv in complex with the extracellular domain(ECD) of HER2

Summary for 6J71

DescriptorReceptor tyrosine-protein kinase erbB-2, anti-HER2 humanized antibody HuA21, BETA-D-MANNOSE, ... (4 entities in total)
Functional Keywordstyrosine-protein kinase, antibody, transcription regulation, signaling protein
Biological sourceHomo sapiens (Human)
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Total number of polymer chains2
Total molecular weight95907.79
Authors
Wang, Z.,Guo, G.,Cheng, B.,Zhu, Z.,Niu, L.,Zhang, H. (deposition date: 2019-01-16, release date: 2019-02-27)
Primary citation
Wang, Z.,Cheng, L.,Guo, G.,Cheng, B.,Hu, S.,Zhang, H.,Zhu, Z.,Niu, L.
Structural insight into a matured humanized monoclonal antibody HuA21 against HER2-overexpressing cancer cells
To Be Published,
Experimental method
X-RAY DIFFRACTION (2.918 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2301400 4.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

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