3FMZ

Crystal Structure of Retinol-Binding Protein 4 (RBP4) in complex with non-retinoid ligand

Summary for 3FMZ

Entry DOI	10.2210/pdb3fmz/pdb
Descriptor	Retinol-binding protein 4, 2-[({4-[2-(trifluoromethyl)phenyl]piperidin-1-yl}carbonyl)amino]benzoic acid (3 entities in total)
Functional Keywords	retinol binding, disease mutation, retinol-binding, secreted, sensory transduction, transport, vision, vitamin a, transport protein
Biological source	Homo sapiens (Human)
Cellular location	Secreted: P02753
Total number of polymer chains	2
Total formula weight	50025.70
Authors	Wang, Z.,Johnstone, S.,Walker, N.P. (deposition date: 2008-12-22, release date: 2009-01-27, Last modification date: 2011-07-13)
Primary citation	Motani, A.,Wang, Z.,Conn, M.,Siegler, K.,Zhang, Y.,Liu, Q.,Johnstone, S.,Xu, H.,Thibault, S.,Wang, Y.,Fan, P.,Connors, R.,Le, H.,Xu, G.,Walker, N.,Shan, B.,Coward, P. Identification and Characterization of a Non-retinoid Ligand for Retinol-binding Protein 4 Which Lowers Serum Retinol-binding Protein 4 Levels in Vivo. J.Biol.Chem., 284:7673-7680, 2009 Cited by PubMed: 19147488 DOI: 10.1074/jbc.M809654200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation