4O9S
Crystal structure of Retinol-Binding Protein 4 (RBP4)in complex with a non-retinoid ligand
Summary for 4O9S
Entry DOI | 10.2210/pdb4o9s/pdb |
Related | 3FMZ 4PSQ |
Descriptor | Retinol-binding protein 4, 1-[4-(7-thia-9,11-diazatricyclo[6.4.0.0^{2,6}]dodeca-1(12),2(6),8,10-tetraen-12-yl)piperazin-1-yl]-2-[2-(trifluoromethyl)phenyl]ethanone, 1,2-ETHANEDIOL, ... (6 entities in total) |
Functional Keywords | retinol binding, disease mutation, retinol-binding, secreted, sensory transduction, transport, vision, vitamin a, transport protein, protein binding |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 52636.94 |
Authors | Wang, Z.,Johnstone, S.,Walker, N.P. (deposition date: 2014-01-02, release date: 2014-07-02, Last modification date: 2020-02-19) |
Primary citation | Wang, Y.,Connors, R.,Fan, P.,Wang, X.,Wang, Z.,Liu, J.,Kayser, F.,Medina, J.C.,Johnstone, S.,Xu, H.,Thibault, S.,Walker, N.,Conn, M.,Zhang, Y.,Liu, Q.,Grillo, M.P.,Motani, A.,Coward, P.,Wang, Z. Structure-assisted discovery of the first non-retinoid ligands for Retinol-Binding Protein 4. Bioorg.Med.Chem.Lett., 24:2885-2891, 2014 Cited by PubMed: 24835984DOI: 10.1016/j.bmcl.2014.04.089 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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