4O9S
Crystal structure of Retinol-Binding Protein 4 (RBP4)in complex with a non-retinoid ligand
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0001654 | biological_process | eye development |
A | 0002639 | biological_process | positive regulation of immunoglobulin production |
A | 0005501 | molecular_function | retinoid binding |
A | 0005515 | molecular_function | protein binding |
A | 0005576 | cellular_component | extracellular region |
A | 0005615 | cellular_component | extracellular space |
A | 0006094 | biological_process | gluconeogenesis |
A | 0007507 | biological_process | heart development |
A | 0007601 | biological_process | visual perception |
A | 0016918 | molecular_function | retinal binding |
A | 0019841 | molecular_function | retinol binding |
A | 0030277 | biological_process | maintenance of gastrointestinal epithelium |
A | 0030324 | biological_process | lung development |
A | 0032024 | biological_process | positive regulation of insulin secretion |
A | 0032526 | biological_process | response to retinoic acid |
A | 0034632 | molecular_function | retinol transmembrane transporter activity |
A | 0034633 | biological_process | retinol transport |
A | 0042572 | biological_process | retinol metabolic process |
A | 0042593 | biological_process | glucose homeostasis |
A | 0048562 | biological_process | embryonic organ morphogenesis |
A | 0048706 | biological_process | embryonic skeletal system development |
A | 0048738 | biological_process | cardiac muscle tissue development |
A | 0048807 | biological_process | female genitalia morphogenesis |
A | 0060044 | biological_process | negative regulation of cardiac muscle cell proliferation |
A | 0060059 | biological_process | embryonic retina morphogenesis in camera-type eye |
A | 0060065 | biological_process | uterus development |
A | 0060068 | biological_process | vagina development |
A | 0060157 | biological_process | urinary bladder development |
A | 0060347 | biological_process | heart trabecula formation |
A | 0070062 | cellular_component | extracellular exosome |
B | 0001654 | biological_process | eye development |
B | 0002639 | biological_process | positive regulation of immunoglobulin production |
B | 0005501 | molecular_function | retinoid binding |
B | 0005515 | molecular_function | protein binding |
B | 0005576 | cellular_component | extracellular region |
B | 0005615 | cellular_component | extracellular space |
B | 0006094 | biological_process | gluconeogenesis |
B | 0007507 | biological_process | heart development |
B | 0007601 | biological_process | visual perception |
B | 0016918 | molecular_function | retinal binding |
B | 0019841 | molecular_function | retinol binding |
B | 0030277 | biological_process | maintenance of gastrointestinal epithelium |
B | 0030324 | biological_process | lung development |
B | 0032024 | biological_process | positive regulation of insulin secretion |
B | 0032526 | biological_process | response to retinoic acid |
B | 0034632 | molecular_function | retinol transmembrane transporter activity |
B | 0034633 | biological_process | retinol transport |
B | 0042572 | biological_process | retinol metabolic process |
B | 0042593 | biological_process | glucose homeostasis |
B | 0048562 | biological_process | embryonic organ morphogenesis |
B | 0048706 | biological_process | embryonic skeletal system development |
B | 0048738 | biological_process | cardiac muscle tissue development |
B | 0048807 | biological_process | female genitalia morphogenesis |
B | 0060044 | biological_process | negative regulation of cardiac muscle cell proliferation |
B | 0060059 | biological_process | embryonic retina morphogenesis in camera-type eye |
B | 0060065 | biological_process | uterus development |
B | 0060068 | biological_process | vagina development |
B | 0060157 | biological_process | urinary bladder development |
B | 0060347 | biological_process | heart trabecula formation |
B | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE 2RY A 201 |
Chain | Residue |
A | LEU35 |
A | TYR90 |
A | ASP102 |
A | ARG121 |
A | TYR133 |
A | PHE135 |
A | HOH303 |
A | PHE36 |
A | LEU37 |
A | ALA55 |
A | ALA57 |
A | MET73 |
A | VAL74 |
A | GLY75 |
A | MET88 |
site_id | AC2 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE EDO A 202 |
Chain | Residue |
A | GLU81 |
A | ASP82 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO A 203 |
Chain | Residue |
A | PHE9 |
A | ARG10 |
A | VAL107 |
A | ARG155 |
A | GLU158 |
A | EDO211 |
site_id | AC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EDO A 204 |
Chain | Residue |
A | ASP126 |
A | LEU144 |
A | HOH311 |
site_id | AC5 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE EDO A 205 |
Chain | Residue |
A | THR80 |
A | GLU81 |
site_id | AC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EDO A 206 |
Chain | Residue |
A | GLN156 |
A | ARG163 |
A | TYR165 |
site_id | AC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO A 207 |
Chain | Residue |
A | VAL42 |
A | THR56 |
A | ALA57 |
A | LYS58 |
site_id | AC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE EDO A 208 |
Chain | Residue |
A | ASP31 |
A | GLN164 |
A | ARG166 |
site_id | AC9 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO A 209 |
Chain | Residue |
A | LYS30 |
A | ASP31 |
A | PRO32 |
A | GLU33 |
A | ALA130 |
A | ASP131 |
A | SER132 |
site_id | BC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO A 210 |
Chain | Residue |
A | VAL42 |
A | HIS170 |
A | ASN171 |
A | GLY172 |
site_id | BC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO A 211 |
Chain | Residue |
A | ARG10 |
A | VAL11 |
A | VAL107 |
A | ARG155 |
A | EDO203 |
A | HOH313 |
site_id | BC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO A 212 |
Chain | Residue |
A | ASN142 |
A | HIS170 |
A | PEG217 |
A | HOH354 |
site_id | BC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO A 213 |
Chain | Residue |
A | ASN66 |
A | TRP67 |
B | LEU35 |
B | 2RY201 |
site_id | BC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO A 214 |
Chain | Residue |
A | TRP91 |
B | TRP91 |
B | EDO209 |
B | HOH398 |
site_id | BC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CL A 215 |
Chain | Residue |
A | ASP72 |
A | ALA94 |
A | SER95 |
A | PHE96 |
site_id | BC7 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE CL A 216 |
Chain | Residue |
B | TRP67 |
site_id | BC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE PEG A 217 |
Chain | Residue |
A | ASP103 |
A | CYS120 |
A | HIS170 |
A | ASN171 |
A | EDO212 |
A | HOH400 |
site_id | BC9 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE 2RY B 201 |
Chain | Residue |
A | EDO213 |
B | LEU35 |
B | PHE36 |
B | LEU37 |
B | ALA55 |
B | ALA57 |
B | VAL61 |
B | MET73 |
B | VAL74 |
B | GLY75 |
B | MET88 |
B | TYR90 |
B | ASP102 |
B | ARG121 |
B | TYR133 |
B | PHE135 |
B | HOH307 |
site_id | CC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO B 202 |
Chain | Residue |
A | GLU13 |
A | ASN14 |
B | PRO145 |
B | GLU147 |
site_id | CC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO B 203 |
Chain | Residue |
B | PHE9 |
B | ARG10 |
B | VAL107 |
B | ARG155 |
B | GLU158 |
site_id | CC3 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE EDO B 204 |
Chain | Residue |
B | ASP3 |
site_id | CC4 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO B 205 |
Chain | Residue |
B | ARG10 |
B | VAL11 |
B | LYS12 |
B | VAL107 |
B | ASP108 |
B | ARG155 |
B | HOH318 |
site_id | CC5 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO B 206 |
Chain | Residue |
B | ASP103 |
B | CYS120 |
B | LEU123 |
B | VAL169 |
B | HIS170 |
B | EDO210 |
B | EDO214 |
site_id | CC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO B 207 |
Chain | Residue |
B | LYS30 |
B | ASP31 |
B | GLN164 |
B | HOH394 |
site_id | CC7 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO B 208 |
Chain | Residue |
B | LYS87 |
B | ASN101 |
B | ASP102 |
B | ASP103 |
B | ASN171 |
B | EDO213 |
B | EDO214 |
site_id | CC8 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO B 209 |
Chain | Residue |
A | LEU97 |
A | EDO214 |
B | TRP91 |
B | GLY92 |
B | LEU97 |
B | GLN98 |
B | HOH341 |
site_id | CC9 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE EDO B 210 |
Chain | Residue |
B | LEU123 |
B | PRO141 |
B | ASN142 |
B | HIS170 |
B | EDO206 |
B | EDO214 |
B | HOH368 |
B | HOH411 |
site_id | DC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE EDO B 212 |
Chain | Residue |
B | ARG153 |
B | GLN156 |
B | ARG163 |
B | GLN164 |
B | TYR165 |
B | HOH326 |
site_id | DC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO B 213 |
Chain | Residue |
B | ASN101 |
B | ASP102 |
B | ARG121 |
B | VAL169 |
B | ASN171 |
B | EDO208 |
B | HOH343 |
site_id | DC3 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO B 214 |
Chain | Residue |
B | LYS87 |
B | ASP103 |
B | HIS170 |
B | ASN171 |
B | EDO206 |
B | EDO208 |
B | EDO210 |
site_id | DC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CL B 215 |
Chain | Residue |
B | ASP72 |
B | ALA94 |
B | SER95 |
B | PHE96 |
Functional Information from PROSITE/UniProt
site_id | PS00213 |
Number of Residues | 14 |
Details | LIPOCALIN Lipocalin signature. NFDkaRFSGTWYAM |
Chain | Residue | Details |
A | ASN14-MET27 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:P27485 |
Chain | Residue | Details |
A | GLN98 | |
B | GLN98 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | MOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:Q00724 |
Chain | Residue | Details |
A | ARG121 | |
B | ARG121 |