4O9S
Crystal structure of Retinol-Binding Protein 4 (RBP4)in complex with a non-retinoid ligand
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001523 | biological_process | retinoid metabolic process |
| A | 0001654 | biological_process | eye development |
| A | 0002639 | biological_process | positive regulation of immunoglobulin production |
| A | 0005501 | molecular_function | retinoid binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0006094 | biological_process | gluconeogenesis |
| A | 0007507 | biological_process | heart development |
| A | 0007601 | biological_process | visual perception |
| A | 0009410 | biological_process | response to xenobiotic stimulus |
| A | 0014850 | biological_process | response to muscle activity |
| A | 0016918 | molecular_function | retinal binding |
| A | 0019841 | molecular_function | retinol binding |
| A | 0030277 | biological_process | maintenance of gastrointestinal epithelium |
| A | 0030324 | biological_process | lung development |
| A | 0032024 | biological_process | positive regulation of insulin secretion |
| A | 0032526 | biological_process | response to retinoic acid |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0034632 | molecular_function | retinol transmembrane transporter activity |
| A | 0034633 | biological_process | retinol transport |
| A | 0042572 | biological_process | retinol metabolic process |
| A | 0042593 | biological_process | glucose homeostasis |
| A | 0044877 | molecular_function | protein-containing complex binding |
| A | 0045471 | biological_process | response to ethanol |
| A | 0048562 | biological_process | embryonic organ morphogenesis |
| A | 0048706 | biological_process | embryonic skeletal system development |
| A | 0048738 | biological_process | cardiac muscle tissue development |
| A | 0048807 | biological_process | female genitalia morphogenesis |
| A | 0060044 | biological_process | negative regulation of cardiac muscle cell proliferation |
| A | 0060059 | biological_process | embryonic retina morphogenesis in camera-type eye |
| A | 0060065 | biological_process | uterus development |
| A | 0060068 | biological_process | vagina development |
| A | 0060157 | biological_process | urinary bladder development |
| A | 0060347 | biological_process | heart trabecula formation |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0140104 | molecular_function | molecular carrier activity |
| A | 1904768 | molecular_function | all-trans-retinol binding |
| B | 0001523 | biological_process | retinoid metabolic process |
| B | 0001654 | biological_process | eye development |
| B | 0002639 | biological_process | positive regulation of immunoglobulin production |
| B | 0005501 | molecular_function | retinoid binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0006094 | biological_process | gluconeogenesis |
| B | 0007507 | biological_process | heart development |
| B | 0007601 | biological_process | visual perception |
| B | 0009410 | biological_process | response to xenobiotic stimulus |
| B | 0014850 | biological_process | response to muscle activity |
| B | 0016918 | molecular_function | retinal binding |
| B | 0019841 | molecular_function | retinol binding |
| B | 0030277 | biological_process | maintenance of gastrointestinal epithelium |
| B | 0030324 | biological_process | lung development |
| B | 0032024 | biological_process | positive regulation of insulin secretion |
| B | 0032526 | biological_process | response to retinoic acid |
| B | 0032991 | cellular_component | protein-containing complex |
| B | 0034632 | molecular_function | retinol transmembrane transporter activity |
| B | 0034633 | biological_process | retinol transport |
| B | 0042572 | biological_process | retinol metabolic process |
| B | 0042593 | biological_process | glucose homeostasis |
| B | 0044877 | molecular_function | protein-containing complex binding |
| B | 0045471 | biological_process | response to ethanol |
| B | 0048562 | biological_process | embryonic organ morphogenesis |
| B | 0048706 | biological_process | embryonic skeletal system development |
| B | 0048738 | biological_process | cardiac muscle tissue development |
| B | 0048807 | biological_process | female genitalia morphogenesis |
| B | 0060044 | biological_process | negative regulation of cardiac muscle cell proliferation |
| B | 0060059 | biological_process | embryonic retina morphogenesis in camera-type eye |
| B | 0060065 | biological_process | uterus development |
| B | 0060068 | biological_process | vagina development |
| B | 0060157 | biological_process | urinary bladder development |
| B | 0060347 | biological_process | heart trabecula formation |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0140104 | molecular_function | molecular carrier activity |
| B | 1904768 | molecular_function | all-trans-retinol binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE 2RY A 201 |
| Chain | Residue |
| A | LEU35 |
| A | TYR90 |
| A | ASP102 |
| A | ARG121 |
| A | TYR133 |
| A | PHE135 |
| A | HOH303 |
| A | PHE36 |
| A | LEU37 |
| A | ALA55 |
| A | ALA57 |
| A | MET73 |
| A | VAL74 |
| A | GLY75 |
| A | MET88 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO A 202 |
| Chain | Residue |
| A | GLU81 |
| A | ASP82 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 203 |
| Chain | Residue |
| A | PHE9 |
| A | ARG10 |
| A | VAL107 |
| A | ARG155 |
| A | GLU158 |
| A | EDO211 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 204 |
| Chain | Residue |
| A | ASP126 |
| A | LEU144 |
| A | HOH311 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO A 205 |
| Chain | Residue |
| A | THR80 |
| A | GLU81 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 206 |
| Chain | Residue |
| A | GLN156 |
| A | ARG163 |
| A | TYR165 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 207 |
| Chain | Residue |
| A | VAL42 |
| A | THR56 |
| A | ALA57 |
| A | LYS58 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 208 |
| Chain | Residue |
| A | ASP31 |
| A | GLN164 |
| A | ARG166 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 209 |
| Chain | Residue |
| A | LYS30 |
| A | ASP31 |
| A | PRO32 |
| A | GLU33 |
| A | ALA130 |
| A | ASP131 |
| A | SER132 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 210 |
| Chain | Residue |
| A | VAL42 |
| A | HIS170 |
| A | ASN171 |
| A | GLY172 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 211 |
| Chain | Residue |
| A | ARG10 |
| A | VAL11 |
| A | VAL107 |
| A | ARG155 |
| A | EDO203 |
| A | HOH313 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 212 |
| Chain | Residue |
| A | ASN142 |
| A | HIS170 |
| A | PEG217 |
| A | HOH354 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 213 |
| Chain | Residue |
| A | ASN66 |
| A | TRP67 |
| B | LEU35 |
| B | 2RY201 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 214 |
| Chain | Residue |
| A | TRP91 |
| B | TRP91 |
| B | EDO209 |
| B | HOH398 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 215 |
| Chain | Residue |
| A | ASP72 |
| A | ALA94 |
| A | SER95 |
| A | PHE96 |
| site_id | BC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL A 216 |
| Chain | Residue |
| B | TRP67 |
| site_id | BC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PEG A 217 |
| Chain | Residue |
| A | ASP103 |
| A | CYS120 |
| A | HIS170 |
| A | ASN171 |
| A | EDO212 |
| A | HOH400 |
| site_id | BC9 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE 2RY B 201 |
| Chain | Residue |
| A | EDO213 |
| B | LEU35 |
| B | PHE36 |
| B | LEU37 |
| B | ALA55 |
| B | ALA57 |
| B | VAL61 |
| B | MET73 |
| B | VAL74 |
| B | GLY75 |
| B | MET88 |
| B | TYR90 |
| B | ASP102 |
| B | ARG121 |
| B | TYR133 |
| B | PHE135 |
| B | HOH307 |
| site_id | CC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 202 |
| Chain | Residue |
| A | GLU13 |
| A | ASN14 |
| B | PRO145 |
| B | GLU147 |
| site_id | CC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 203 |
| Chain | Residue |
| B | PHE9 |
| B | ARG10 |
| B | VAL107 |
| B | ARG155 |
| B | GLU158 |
| site_id | CC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO B 204 |
| Chain | Residue |
| B | ASP3 |
| site_id | CC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 205 |
| Chain | Residue |
| B | ARG10 |
| B | VAL11 |
| B | LYS12 |
| B | VAL107 |
| B | ASP108 |
| B | ARG155 |
| B | HOH318 |
| site_id | CC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 206 |
| Chain | Residue |
| B | ASP103 |
| B | CYS120 |
| B | LEU123 |
| B | VAL169 |
| B | HIS170 |
| B | EDO210 |
| B | EDO214 |
| site_id | CC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 207 |
| Chain | Residue |
| B | LYS30 |
| B | ASP31 |
| B | GLN164 |
| B | HOH394 |
| site_id | CC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 208 |
| Chain | Residue |
| B | LYS87 |
| B | ASN101 |
| B | ASP102 |
| B | ASP103 |
| B | ASN171 |
| B | EDO213 |
| B | EDO214 |
| site_id | CC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 209 |
| Chain | Residue |
| A | LEU97 |
| A | EDO214 |
| B | TRP91 |
| B | GLY92 |
| B | LEU97 |
| B | GLN98 |
| B | HOH341 |
| site_id | CC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO B 210 |
| Chain | Residue |
| B | LEU123 |
| B | PRO141 |
| B | ASN142 |
| B | HIS170 |
| B | EDO206 |
| B | EDO214 |
| B | HOH368 |
| B | HOH411 |
| site_id | DC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 212 |
| Chain | Residue |
| B | ARG153 |
| B | GLN156 |
| B | ARG163 |
| B | GLN164 |
| B | TYR165 |
| B | HOH326 |
| site_id | DC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 213 |
| Chain | Residue |
| B | ASN101 |
| B | ASP102 |
| B | ARG121 |
| B | VAL169 |
| B | ASN171 |
| B | EDO208 |
| B | HOH343 |
| site_id | DC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 214 |
| Chain | Residue |
| B | LYS87 |
| B | ASP103 |
| B | HIS170 |
| B | ASN171 |
| B | EDO206 |
| B | EDO208 |
| B | EDO210 |
| site_id | DC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 215 |
| Chain | Residue |
| B | ASP72 |
| B | ALA94 |
| B | SER95 |
| B | PHE96 |
Functional Information from PROSITE/UniProt
| site_id | PS00213 |
| Number of Residues | 14 |
| Details | LIPOCALIN Lipocalin signature. NFDkaRFSGTWYAM |
| Chain | Residue | Details |
| A | ASN14-MET27 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P27485","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"UniProtKB","id":"Q00724","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
