7WE6
 
 | | Structure of Csy-AcrIF24-dsDNA | | 分子名称: | AcrIF24, CRISPR type I-F/YPEST-associated protein Csy2, CRISPR-associated protein Csy3, ... | | 著者 | Zhang, L, Feng, Y. | | 登録日 | 2021-12-22 | | 公開日 | 2022-04-20 | | 最終更新日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Insights into the inhibition of type I-F CRISPR-Cas system by a multifunctional anti-CRISPR protein AcrIF24.
Nat Commun, 13, 2022
|
|
7ELM
 | | Structure of Csy-AcrIF24 | | 分子名称: | AcrIF24, CRISPR type I-F/YPEST-associated protein Csy2, CRISPR-associated protein Csy3, ... | | 著者 | Zhang, L, Feng, Y. | | 登録日 | 2021-04-12 | | 公開日 | 2022-04-20 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | | 主引用文献 | Insights into the inhibition of type I-F CRISPR-Cas system by a multifunctional anti-CRISPR protein AcrIF24.
Nat Commun, 13, 2022
|
|
7ELN
 | | Structure of Csy-AcrIF24-dsDNA | | 分子名称: | 54-MER DNA, AcrIF24, CRISPR type I-F/YPEST-associated protein Csy2, ... | | 著者 | Zhang, L, Feng, Y. | | 登録日 | 2021-04-12 | | 公開日 | 2022-04-20 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Insights into the inhibition of type I-F CRISPR-Cas system by a multifunctional anti-CRISPR protein AcrIF24.
Nat Commun, 13, 2022
|
|
7DTR
 | | Structure of an AcrIF protein | | 分子名称: | AcrIF24 | | 著者 | Yue, F, Peipei, Y. | | 登録日 | 2021-01-06 | | 公開日 | 2022-01-19 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Insights into the inhibition of type I-F CRISPR-Cas system by a multifunctional anti-CRISPR protein AcrIF24.
Nat Commun, 13, 2022
|
|
7VB2
 | |
7X8L
 | |
7B7V
 | |
8WC7
 | | Cryo-EM structure of the ZH8667-bound mTAAR1-Gs complex | | 分子名称: | 2-[4-(3-fluorophenyl)phenyl]ethanamine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P. | | 登録日 | 2023-09-11 | | 公開日 | 2023-12-27 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural and signaling mechanisms of TAAR1 enabled preferential agonist design.
Cell, 186, 2023
|
|
8WC3
 | | Cryo-EM structure of the SEP363856-bound mTAAR1-Gs complex | | 分子名称: | 1-[(7~{S})-5,7-dihydro-4~{H}-thieno[2,3-c]pyran-7-yl]-~{N}-methyl-methanamine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P. | | 登録日 | 2023-09-11 | | 公開日 | 2023-12-27 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural and signaling mechanisms of TAAR1 enabled preferential agonist design.
Cell, 186, 2023
|
|
8WC4
 | | Cryo-EM structure of the ZH8651-bound mTAAR1-Gs complex | | 分子名称: | 2-(4-bromophenyl)ethanamine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P. | | 登録日 | 2023-09-11 | | 公開日 | 2023-12-27 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural and signaling mechanisms of TAAR1 enabled preferential agonist design.
Cell, 186, 2023
|
|
8WC9
 | | Cryo-EM structure of the ZH8651-bound mTAAR1-Gq complex | | 分子名称: | 2-(4-bromophenyl)ethanamine, Engineered G-alpha-q subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P. | | 登録日 | 2023-09-11 | | 公開日 | 2023-12-27 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural and signaling mechanisms of TAAR1 enabled preferential agonist design.
Cell, 186, 2023
|
|
8WCA
 | | Cryo-EM structure of the PEA-bound hTAAR1-Gs complex | | 分子名称: | 2-PHENYLETHYLAMINE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P. | | 登録日 | 2023-09-11 | | 公開日 | 2023-12-27 | | 実験手法 | ELECTRON MICROSCOPY (3.48 Å) | | 主引用文献 | Structural and signaling mechanisms of TAAR1 enabled preferential agonist design.
Cell, 186, 2023
|
|
8WC8
 | | Cryo-EM structure of the ZH8651-bound hTAAR1-Gs complex | | 分子名称: | 2-(4-bromophenyl)ethanamine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P. | | 登録日 | 2023-09-11 | | 公開日 | 2023-12-27 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural and signaling mechanisms of TAAR1 enabled preferential agonist design.
Cell, 186, 2023
|
|
8WCB
 | | Cryo-EM structure of the CHA-bound mTAAR1-Gq complex | | 分子名称: | CYCLOHEXYLAMMONIUM ION, Engineered G-alpha-q subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P. | | 登録日 | 2023-09-11 | | 公開日 | 2023-12-27 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural and signaling mechanisms of TAAR1 enabled preferential agonist design.
Cell, 186, 2023
|
|
8WC6
 | | Cryo-EM structure of the PEA-bound mTAAR1-Gs complex | | 分子名称: | 2-PHENYLETHYLAMINE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P. | | 登録日 | 2023-09-11 | | 公開日 | 2023-12-27 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural and signaling mechanisms of TAAR1 enabled preferential agonist design.
Cell, 186, 2023
|
|
8WC5
 | | Cryo-EM structure of the TMA-bound mTAAR1-Gs complex | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | 著者 | Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P. | | 登録日 | 2023-09-11 | | 公開日 | 2023-12-27 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structural and signaling mechanisms of TAAR1 enabled preferential agonist design.
Cell, 186, 2023
|
|
8WCC
 | | Cryo-EM structure of the CHA-bound mTAAR1 complex | | 分子名称: | CYCLOHEXYLAMMONIUM ION, Trace amine-associated receptor 1 | | 著者 | Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P. | | 登録日 | 2023-09-11 | | 公開日 | 2023-12-27 | | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | | 主引用文献 | Structural and signaling mechanisms of TAAR1 enabled preferential agonist design.
Cell, 186, 2023
|
|
6PKA
 | |
6P65
 | | HIV Env 16055 NFL TD 2CC+ in complex with antibody 1C2 fragment antigen binding | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Ozorowski, G, Torres, J.L, Ward, A.B. | | 登録日 | 2019-05-31 | | 公開日 | 2019-11-20 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (3.94 Å) | | 主引用文献 | Vaccination with Glycan-Modified HIV NFL Envelope Trimer-Liposomes Elicits Broadly Neutralizing Antibodies to Multiple Sites of Vulnerability.
Immunity, 51, 2019
|
|
6PMD
 | |
7PVC
 | |
8II0
 | | FACTOR INHIBITING HIF-1 ALPHA in complex with (5-(3-(3-chlorophenyl)isoxazol-5-yl)-3-hydroxypicolinoyl)glycine | | 分子名称: | 2-[[5-[3-(3-chlorophenyl)-1,2-oxazol-5-yl]-3-oxidanyl-pyridin-2-yl]carbonylamino]ethanoic acid, GLYCEROL, Hypoxia-inducible factor 1-alpha inhibitor, ... | | 著者 | Nakashima, Y, Corner, T, Zhang, X, Schofield, C.J. | | 登録日 | 2023-02-24 | | 公開日 | 2024-02-28 | | 最終更新日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | | 主引用文献 | A Small-Molecule Inhibitor of Factor Inhibiting HIF Binding to a Tyrosine-flip Pocket for the Treatment of Obesity.
Angew.Chem.Int.Ed.Engl., 2024
|
|
8IHZ
 | | FACTOR INHIBITING HIF-1 ALPHA in complex with (5-(1-(3-(4-chlorophenyl)propyl)-1H-1,2,3-triazol-4-yl)-3-hydroxypicolinoyl)glycine | | 分子名称: | 2-[[5-[1-[3-(4-chlorophenyl)propyl]-1,2,3-triazol-4-yl]-3-oxidanyl-pyridin-2-yl]carbonylamino]ethanoic acid, Hypoxia-inducible factor 1-alpha inhibitor, SULFATE ION, ... | | 著者 | Nakashima, Y, Corner, T, Zhang, X, Schofield, C.J. | | 登録日 | 2023-02-24 | | 公開日 | 2024-02-28 | | 最終更新日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | | 主引用文献 | A Small-Molecule Inhibitor of Factor Inhibiting HIF Binding to a Tyrosine-flip Pocket for the Treatment of Obesity.
Angew.Chem.Int.Ed.Engl., 2024
|
|
5NB7
 | | Complement factor D | | 分子名称: | 1-[2-[(1~{R},3~{S},5~{R})-3-[(6-bromanylpyridin-2-yl)carbamoyl]-2-azabicyclo[3.1.0]hexan-2-yl]-2-oxidanylidene-ethyl]indazole-3-carboxamide, Complement factor D, DIMETHYL SULFOXIDE | | 著者 | Mac Sweeney, A, Ostermann, N. | | 登録日 | 2017-03-01 | | 公開日 | 2017-06-28 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.33 Å) | | 主引用文献 | Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo.
J. Med. Chem., 60, 2017
|
|
6WTQ
 | | Human JAK2 JH1 domain in complex with PROTAC-intermediate linker handle 4 | | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, N-methyl-4-{[4-(1-propyl-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}benzamide, ... | | 著者 | Yu, S, Nithianantham, S, Fischer, M. | | 登録日 | 2020-05-03 | | 公開日 | 2021-05-05 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.79968476 Å) | | 主引用文献 | Degradation of Janus kinases in CRLF2-rearranged acute lymphoblastic leukemia.
Blood, 138, 2021
|
|
