7FB8
| De Novo-Designed and Disulfide-Bridged Peptide Heterodimer - hd1 | 分子名称: | ASP-ASP-LYS-ASP-CYS-ASP-GLU-TYR-CYS-LYS-LYS-THR-LYS-GLU-NH2, GLU-LE1-THR-GLY-HIS-ILE-GLU-GLY-PRO-THR-LE1-THR-LE1-HIS-CYS-LYS-NH2 | 著者 | Yao, H, Yao, S, Zheng, Y, Moyer, A, Baker, D, Wu, C. | 登録日 | 2021-07-08 | 公開日 | 2022-05-18 | 最終更新日 | 2023-11-15 | 実験手法 | SOLUTION NMR | 主引用文献 | De novo design and directed folding of disulfide-bridged peptide heterodimers. Nat Commun, 13, 2022
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3QBA
| Reintroducing Electrostatics into Macromolecular Crystallographic Refinement: Z-DNA (X-ray) | 分子名称: | Z-DNA | 著者 | Fenn, T.D, Schnieders, M.J, Mustyakimov, M, Wu, C, Langan, P, Pande, V.S, Brunger, A.T. | 登録日 | 2011-01-12 | 公開日 | 2011-03-02 | 最終更新日 | 2024-02-21 | 実験手法 | NEUTRON DIFFRACTION (1.53 Å), X-RAY DIFFRACTION | 主引用文献 | Reintroducing electrostatics into macromolecular crystallographic refinement: application to neutron crystallography and DNA hydration. Structure, 19, 2011
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7XOD
| SARS-CoV-2 Omicron BA.2 Variant Spike Trimer with three JMB2002 Fab Bound | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of JMB2002 Fab, ... | 著者 | Xu, Y, Wu, C, Liu, H, Yin, W, Xu, H.E. | 登録日 | 2022-05-01 | 公開日 | 2022-06-15 | 最終更新日 | 2022-07-13 | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | 主引用文献 | Structural and biochemical mechanism for increased infectivity and immune evasion of Omicron BA.2 variant compared to BA.1 and their possible mouse origins. Cell Res., 32, 2022
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7XO6
| SARS-CoV-2 Omicron BA.1 Variant RBD with mouse ACE2 Bound | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... | 著者 | Xu, Y, Wu, C, Liu, H, Yin, W, Xu, H.E. | 登録日 | 2022-05-01 | 公開日 | 2022-06-15 | 最終更新日 | 2022-07-13 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Structural and biochemical mechanism for increased infectivity and immune evasion of Omicron BA.2 variant compared to BA.1 and their possible mouse origins. Cell Res., 32, 2022
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7XO5
| SARS-CoV-2 Omicron BA.1 Variant Spike Trimer with one mouse ACE2 Bound | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, Spike glycoprotein, ... | 著者 | Xu, Y, Wu, C, Liu, H, Yin, W, Xu, H.E. | 登録日 | 2022-05-01 | 公開日 | 2022-06-15 | 最終更新日 | 2022-07-13 | 実験手法 | ELECTRON MICROSCOPY (3.13 Å) | 主引用文献 | Structural and biochemical mechanism for increased infectivity and immune evasion of Omicron BA.2 variant compared to BA.1 and their possible mouse origins. Cell Res., 32, 2022
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7XOC
| SARS-CoV-2 Omicron BA.2 Variant RBD complexed with mouse ACE2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... | 著者 | Xu, Y, Wu, C, Liu, H, Yin, W, Xu, H.E. | 登録日 | 2022-05-01 | 公開日 | 2022-06-15 | 最終更新日 | 2022-07-13 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural and biochemical mechanism for increased infectivity and immune evasion of Omicron BA.2 variant compared to BA.1 and their possible mouse origins. Cell Res., 32, 2022
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7XO8
| SARS-CoV-2 Omicron BA.2 Variant Spike Trimer with three human ACE2 Bound | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, CHLORIDE ION, ... | 著者 | Xu, Y, Wu, C, Liu, H, Yin, W, Xu, H.E. | 登録日 | 2022-05-01 | 公開日 | 2022-06-15 | 最終更新日 | 2022-07-13 | 実験手法 | ELECTRON MICROSCOPY (3.48 Å) | 主引用文献 | Structural and biochemical mechanism for increased infectivity and immune evasion of Omicron BA.2 variant compared to BA.1 and their possible mouse origins. Cell Res., 32, 2022
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7XO9
| SARS-CoV-2 Omicron BA.2 Variant RBD complexed with human ACE2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, CHLORIDE ION, ... | 著者 | Xu, Y, Wu, C, Liu, H, Yin, W, Xu, H.E. | 登録日 | 2022-05-01 | 公開日 | 2022-06-15 | 最終更新日 | 2022-07-13 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural and biochemical mechanism for increased infectivity and immune evasion of Omicron BA.2 variant compared to BA.1 and their possible mouse origins. Cell Res., 32, 2022
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7XOA
| SARS-CoV-2 Omicron BA.2 Variant Spike Trimer with one mouse ACE2 Bound | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, Spike glycoprotein, ... | 著者 | Xu, Y, Wu, C, Liu, H, Yin, W, Xu, H.E. | 登録日 | 2022-05-01 | 公開日 | 2022-06-15 | 最終更新日 | 2022-07-13 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural and biochemical mechanism for increased infectivity and immune evasion of Omicron BA.2 variant compared to BA.1 and their possible mouse origins. Cell Res., 32, 2022
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7XOB
| SARS-CoV-2 Omicron BA.2 Variant Spike Trimer with two mouse ACE2 Bound | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, Spike glycoprotein, ... | 著者 | Xu, Y, Wu, C, Liu, H, Yin, W, Xu, H.E. | 登録日 | 2022-05-01 | 公開日 | 2022-06-15 | 最終更新日 | 2022-07-13 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural and biochemical mechanism for increased infectivity and immune evasion of Omicron BA.2 variant compared to BA.1 and their possible mouse origins. Cell Res., 32, 2022
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7XO4
| SARS-CoV-2 Omicron BA.1 Variant Spike Trimer with two mouse ACE2 Bound | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, Spike glycoprotein, ... | 著者 | Xu, Y, Wu, C, Liu, H, Yin, W, Xu, H.E. | 登録日 | 2022-04-30 | 公開日 | 2022-06-15 | 最終更新日 | 2022-07-13 | 実験手法 | ELECTRON MICROSCOPY (3.24 Å) | 主引用文献 | Structural and biochemical mechanism for increased infectivity and immune evasion of Omicron BA.2 variant compared to BA.1 and their possible mouse origins. Cell Res., 32, 2022
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7XO7
| SARS-CoV-2 Omicron BA.2 Variant Spike Trimer with two human ACE2 Bound | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, CHLORIDE ION, ... | 著者 | Xu, Y, Wu, C, Liu, H, Yin, W, Xu, H.E. | 登録日 | 2022-05-01 | 公開日 | 2022-06-15 | 最終更新日 | 2022-07-13 | 実験手法 | ELECTRON MICROSCOPY (3.38 Å) | 主引用文献 | Structural and biochemical mechanism for increased infectivity and immune evasion of Omicron BA.2 variant compared to BA.1 and their possible mouse origins. Cell Res., 32, 2022
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4M6B
| Crystal structure of yeast Swr1-Z domain in complex with H2A.Z-H2B dimer | 分子名称: | Chimera protein of Histone H2B.1 and Histone H2A.Z, Helicase SWR1 | 著者 | Hong, J.J, Feng, H.Q, Wang, F, Ranjan, A, Chen, J.H, Jiang, J.S, Girlando, R, Xiao, T.S, Wu, C, Bai, Y.W. | 登録日 | 2013-08-09 | 公開日 | 2014-02-19 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | The Catalytic Subunit of the SWR1 Remodeler Is a Histone Chaperone for the H2A.Z-H2B Dimer. Mol.Cell, 53, 2014
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2L5A
| Structural basis for recognition of centromere specific histone H3 variant by nonhistone Scm3 | 分子名称: | Histone H3-like centromeric protein CSE4, Protein SCM3, Histone H4 | 著者 | Zhou, Z, Feng, H, Zhou, B, Ghirlando, R, Hu, K, Zwolak, A, Jenkins, L, Xiao, H, Tjandra, N, Wu, C, Bai, Y. | 登録日 | 2010-10-28 | 公開日 | 2011-03-16 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural basis for recognition of centromere histone variant CenH3 by the chaperone Scm3. Nature, 472, 2011
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2K2R
| The NMR structure of alpha-parvin CH2/paxillin LD1 complex | 分子名称: | Alpha-parvin, Paxillin | 著者 | Wang, X, Fukuda, K, Byeon, I, Velyvis, A, Wu, C, Gronenborn, A, Qin, J. | 登録日 | 2008-04-10 | 公開日 | 2008-05-27 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | The Structure of {alpha}-Parvin CH2-Paxillin LD1 Complex Reveals a Novel Modular Recognition for Focal Adhesion Assembly. J.Biol.Chem., 283, 2008
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2JSS
| NMR structure of chaperone Chz1 complexed with histone H2A.Z-H2B | 分子名称: | Chimera of Histone H2B.1 and Histone H2A.Z, Uncharacterized protein YER030W | 著者 | Zhou, Z, Feng, H, Hansen, D.F, Kato, H, Luk, E, Freedberg, D.I, Kay, L.E, Wu, C, Bai, Y. | 登録日 | 2007-07-11 | 公開日 | 2008-05-20 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | NMR structure of chaperone Chz1 complexed with histones H2A.Z-H2B. Nat.Struct.Mol.Biol., 15, 2008
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7ENQ
| Crystal structure of human NAMPT in complex with compound NAT | 分子名称: | 2-(2-~{tert}-butylphenoxy)-~{N}-(4-hydroxyphenyl)ethanamide, Nicotinamide phosphoribosyltransferase, PHOSPHATE ION | 著者 | Wang, G, Wu, C, Liu, M, Yao, H, Li, C, Wang, L, Tang, Y. | 登録日 | 2021-04-19 | 公開日 | 2022-05-04 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.204966 Å) | 主引用文献 | Discovery of small-molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and their preclinical neuroprotective activity. Cell Res., 32, 2022
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2LAS
| Molecular Determinants of Paralogue-Specific SUMO-SIM Recognition | 分子名称: | M-IR2_peptide, Small ubiquitin-related modifier 1 | 著者 | Namanja, A, Li, Y, Su, Y, Wong, S, Lu, J, Colson, L, Wu, C, Li, S, Chen, Y. | 登録日 | 2011-03-20 | 公開日 | 2011-12-14 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Insights into High Affinity Small Ubiquitin-like Modifier (SUMO) Recognition by SUMO-interacting Motifs (SIMs) Revealed by a Combination of NMR and Peptide Array Analysis. J.Biol.Chem., 287, 2012
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7CE2
| The Crystal structure of TeNT Hc complexed with neutralizing antibody | 分子名称: | Tetanus toxin, neutralizing antibody heavy chain, neutralizing antibody light chain | 著者 | Wang, X, Wang, Y, Wu, C, Yu, J, Liao, H. | 登録日 | 2020-06-21 | 公開日 | 2021-04-07 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Structural basis of tetanus toxin neutralization by native human monoclonal antibodies. Cell Rep, 35, 2021
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6IMG
| Solution Structure of Bicyclic Peptide pb-13 | 分子名称: | (ACE)-GLY-CYS-PRO-CYS-ILE-TRP-PRO-GLU-LEU-CYS-PRO-TRP-ILE-ARG-SER-CYS-(NH2) | 著者 | Yao, H, Lin, P, Zha, J, Zha, M, Zhao, Y, Wu, C. | 登録日 | 2018-10-22 | 公開日 | 2019-08-28 | 実験手法 | SOLUTION NMR | 主引用文献 | Ordered and Isomerically Stable Bicyclic Peptide Scaffolds Constrained through Cystine Bridges and Proline Turns. Chembiochem, 20, 2019
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6IMH
| Solution Structure of Bicyclic Peptide pb-18 | 分子名称: | (ACE)-GLY-CYS-PRO-CYS-GLU-PRO-SER-TYR-LEU-CYS-PRO-TRP-LEU-PRO-GLY-CYS-(NH2) | 著者 | Yao, H, Lin, P, Zha, J, Zha, M, Zhao, Y, Wu, C. | 登録日 | 2018-10-22 | 公開日 | 2019-08-28 | 実験手法 | SOLUTION NMR | 主引用文献 | Ordered and Isomerically Stable Bicyclic Peptide Scaffolds Constrained through Cystine Bridges and Proline Turns. Chembiochem, 20, 2019
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7YDX
| Crystal structure of human RIPK1 kinase domain in complex with compound RI-962 | 分子名称: | 1-methyl-5-[2-(2-methylpropanoylamino)-[1,2,4]triazolo[1,5-a]pyridin-7-yl]-N-[(1S)-1-phenylethyl]indole-3-carboxamide, IODIDE ION, Receptor-interacting serine/threonine-protein kinase 1 | 著者 | Zhang, L, Wang, Y, Li, Y, Wu, C, Luo, X, Wang, T, Lei, J, Yang, S. | 登録日 | 2022-07-04 | 公開日 | 2023-04-19 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.642 Å) | 主引用文献 | Generative deep learning enables the discovery of a potent and selective RIPK1 inhibitor. Nat Commun, 13, 2022
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7CJT
| Crystal Structure of SETDB1 Tudor domain in complexed with (R,R)-59 | 分子名称: | 2-[[(3~{R},5~{R})-1-methyl-5-(4-phenylmethoxyphenyl)piperidin-3-yl]amino]-3-prop-2-enyl-5~{H}-pyrrolo[3,2-d]pyrimidin-4-one, Histone-lysine N-methyltransferase SETDB1 | 著者 | Guo, Y.P, Liang, X, Mao, X, Wu, C, Luyi, H, Yang, S. | 登録日 | 2020-07-13 | 公開日 | 2021-04-14 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.474 Å) | 主引用文献 | Structure-Guided Discovery of a Potent and Selective Cell-Active Inhibitor of SETDB1 Tudor Domain. Angew.Chem.Int.Ed.Engl., 60, 2021
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7CD9
| Crystal Structure of SETDB1 tudor domain in complexed with Compound 6 | 分子名称: | 3-methyl-2-[[(3R,5R)-1-methyl-5-(4-phenylmethoxyphenyl)piperidin-3-yl]amino]-5H-pyrrolo[3,2-d]pyrimidin-4-one, CITRIC ACID, Histone-lysine N-methyltransferase SETDB1 | 著者 | Xiong, L, Guo, Y, Mao, X, Huang, L, Wu, C, Yang, S. | 登録日 | 2020-06-19 | 公開日 | 2021-04-07 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structure-Guided Discovery of a Potent and Selective Cell-Active Inhibitor of SETDB1 Tudor Domain. Angew.Chem.Int.Ed.Engl., 60, 2021
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7ELY
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