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7DNI
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BU of 7dni by Molmil
MDA5 CARDs-MAVS CARD polyUb complex
分子名称: Interferon-induced helicase C domain-containing protein 1, Mitochondrial antiviral-signaling protein, Ubiquitin
著者Song, B, Chen, Y, Luo, D.H, Zheng, J.
登録日2020-12-09
公開日2021-10-13
最終更新日2025-06-25
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Ordered assembly of the cytosolic RNA-sensing MDA5-MAVS signaling complex via binding to unanchored K63-linked poly-ubiquitin chains.
Immunity, 54, 2021
7X01
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BU of 7x01 by Molmil
Cryo-EM Structure of Chikungunya Virus Nonstructural Protein 1 with inhibitor FHA
分子名称: (1R,2S,3S,4R,5R)-3-(6-aminopurin-9-yl)-4-fluoranyl-5-(2-hydroxyethyl)cyclopentane-1,2-diol, ZINC ION, mRNA-capping enzyme nsP1
著者Zhang, K, Law, M.C.Y, Nguyen, T.M, Tan, Y.B, Wirawan, M, Law, Y.S, Luo, D.H.
登録日2022-02-20
公開日2022-08-10
最終更新日2025-06-18
実験手法ELECTRON MICROSCOPY (2.62 Å)
主引用文献Molecular basis of specific viral RNA recognition and 5'-end capping by the Chikungunya virus nsP1.
Cell Rep, 40, 2022
7VLI
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BU of 7vli by Molmil
Crystal structure of Zika NS2B-NS3 protease with compound MI2220
分子名称: 1-[(3~{S},6~{S},19~{R})-3,6-bis(4-azanylbutyl)-2,5,8,12,15,18-hexakis(oxidanylidene)-1,4,7,11,14,17-hexazacyclotricos-19-yl]guanidine, NS3 protease, SULFATE ION, ...
著者Quek, J.P.
登録日2021-10-02
公開日2022-08-10
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.385 Å)
主引用文献Structure-Based Optimization and Characterization of Macrocyclic Zika Virus NS2B-NS3 Protease Inhibitors.
J.Med.Chem., 65, 2022
7VLG
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BU of 7vlg by Molmil
Crystal structure of Zika NS2B-NS3 protease with compound MI2201
分子名称: 1-[(5~{R},8~{R},15~{S},18~{S})-15,18-bis(4-azanylbutyl)-4,7,14,17,20-pentakis(oxidanylidene)-5-propan-2-yl-3,6,13,16,19-pentazabicyclo[20.3.1]hexacosa-1(25),22(26),23-trien-8-yl]guanidine, NS3 protease, SULFATE ION, ...
著者Quek, J.P.
登録日2021-10-02
公開日2022-08-10
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.771 Å)
主引用文献Structure-Based Optimization and Characterization of Macrocyclic Zika Virus NS2B-NS3 Protease Inhibitors.
J.Med.Chem., 65, 2022
7VLH
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BU of 7vlh by Molmil
Crystal structure of Zika NS2B-NS3 protease with compound MI2219
分子名称: 1-[(3~{S},6~{R},18~{R})-3,6-bis(4-azanylbutyl)-2,5,8,11,14,17-hexakis(oxidanylidene)-1,4,7,10,13,16-hexazacyclodocos-18-yl]guanidine, NS3 protease, SULFATE ION, ...
著者Quek, J.P.
登録日2021-10-02
公開日2022-08-10
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.621 Å)
主引用文献Structure-Based Optimization and Characterization of Macrocyclic Zika Virus NS2B-NS3 Protease Inhibitors.
J.Med.Chem., 65, 2022
7VHQ
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BU of 7vhq by Molmil
Structural insights into the membrane microdomain organization by SPFH family proteins
分子名称: ATP-dependent zinc metalloprotease FtsH, Modulator of FtsH protease HflC, Protein HflK
著者Ma, C.Y, Wang, C.K, Luo, D.Y, Yan, L, Yang, W.X, Li, N.N, Gao, N.
登録日2021-09-22
公開日2022-01-19
最終更新日2025-06-25
実験手法ELECTRON MICROSCOPY (3.27 Å)
主引用文献Structural insights into the membrane microdomain organization by SPFH family proteins.
Cell Res., 32, 2022
7VHP
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BU of 7vhp by Molmil
Structural insights into the membrane microdomain organization by SPFH family proteins
分子名称: ATP-dependent zinc metalloprotease FtsH, Modulator of FtsH protease HflC, Protein HflK
著者Ma, C.Y, Wang, C.K, Luo, D.Y, Yan, L, Yang, W.X, Li, N.N, Gao, N.
登録日2021-09-22
公開日2022-03-23
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (3.27 Å)
主引用文献Structural insights into the membrane microdomain organization by SPFH family proteins.
Cell Res., 32, 2022
7DOP
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BU of 7dop by Molmil
Structural insights into viral RNA capping and plasma membrane targeting by Chikungunya virus nonstructural protein 1
分子名称: Nonstructural Protein 1, ZINC ION
著者Zhang, K, Law, Y.S, Law, M.C.Y, Tan, Y.B, Wirawan, M, Luo, D.H.
登録日2020-12-15
公開日2021-03-24
最終更新日2025-06-25
実験手法ELECTRON MICROSCOPY (2.38 Å)
主引用文献Structural insights into viral RNA capping and plasma membrane targeting by Chikungunya virus nonstructural protein 1.
Cell Host Microbe, 29, 2021
7D2L
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BU of 7d2l by Molmil
Crystal structure of the Cas12i1 R-loop complex before target DNA cleavage
分子名称: 12i1-D647A, CITRIC ACID, DNA (26-MER), ...
著者Zhang, B, Luo, D.Y, Li, Y, OuYang, S.Y.
登録日2020-09-16
公開日2021-05-19
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Mechanistic insights into the R-loop formation and cleavage in CRISPR-Cas12i1.
Nat Commun, 12, 2021
7D8C
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BU of 7d8c by Molmil
Crystal structure of the Cas12i1-crRNA binary complex
分子名称: 12i1, CITRIC ACID, RNA (3-MER), ...
著者Zhang, B, Luo, D.Y, Li, Y, OuYang, S.Y.
登録日2020-10-07
公開日2021-05-19
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Mechanistic insights into the R-loop formation and cleavage in CRISPR-Cas12i1.
Nat Commun, 12, 2021
7D3J
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BU of 7d3j by Molmil
Crystal structure of the Cas12i1 R-loop complex after target DNA cleavage
分子名称: 12i1-WT, CITRIC ACID, DNA (23-MER), ...
著者Zhang, B, Luo, D.Y, Li, Y, OuYang, S.Y.
登録日2020-09-19
公開日2021-05-19
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Mechanistic insights into the R-loop formation and cleavage in CRISPR-Cas12i1.
Nat Commun, 12, 2021
7EU9
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BU of 7eu9 by Molmil
Crystal structure of the selenomethionine(SeMet)-derived Cas12i1 R-loop complex before target DNA cleavage
分子名称: CITRIC ACID, Cas12i1 D647A mutant, DNA (24-MER), ...
著者Zhang, B, Luo, D.Y, Li, Y, OuYang, S.Y.
登録日2021-05-16
公開日2021-05-26
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Mechanistic insights into the R-loop formation and cleavage in CRISPR-Cas12i1.
Nat Commun, 12, 2021
7PGC
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BU of 7pgc by Molmil
Crystal Structure of Unlinked NS2B-NS3 Protease from Zika Virus in Complex with Inhibitor MI-2191
分子名称: Inhibitor MI-2191, Serine protease NS3, Serine protease subunit NS2B
著者Huber, S, Heine, A, Steinmetzer, T.
登録日2021-08-13
公開日2022-08-24
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Structure-Based Optimization and Characterization of Macrocyclic Zika Virus NS2B-NS3 Protease Inhibitors.
J.Med.Chem., 65, 2022
7PFZ
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BU of 7pfz by Molmil
Crystal Structure of Unlinked NS2B-NS3 Protease from Zika Virus in Complex with Inhibitor MI-2267
分子名称: Inhibitor MI-2267, Serine protease NS3, Serine protease subunit NS2B
著者Huber, S, Heine, A, Steinmetzer, T.
登録日2021-08-12
公開日2022-09-14
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Structure-Based Optimization and Characterization of Macrocyclic Zika Virus NS2B-NS3 Protease Inhibitors.
J.Med.Chem., 65, 2022
7PFY
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BU of 7pfy by Molmil
Crystal Structure of Unlinked NS2B-NS3 Protease from Zika Virus in Complex with Inhibitor MI-2241
分子名称: Inhibitor MI-2241, Serine protease NS3, Serine protease subunit NS2B
著者Huber, S, Heine, A, Steinmetzer, T.
登録日2021-08-12
公開日2022-08-24
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.38 Å)
主引用文献Structure-Based Optimization and Characterization of Macrocyclic Zika Virus NS2B-NS3 Protease Inhibitors.
J.Med.Chem., 65, 2022
7PG1
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BU of 7pg1 by Molmil
Crystal Structure of Unlinked NS2B-NS3 Protease from Zika Virus in Complex with Inhibitor MI-2221
分子名称: Inhibitor MI-2221, Serine protease NS3, Serine protease subunit NS2B
著者Huber, S, Heine, A, Steinmetzer, T.
登録日2021-08-12
公開日2022-08-24
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structure-Based Optimization and Characterization of Macrocyclic Zika Virus NS2B-NS3 Protease Inhibitors.
J.Med.Chem., 65, 2022
7PFQ
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BU of 7pfq by Molmil
Crystal Structure of Unlinked NS2B-NS3 Protease from Zika Virus in Complex with Inhibitor MI-2247
分子名称: Inhibitor MI-2247, Serine protease NS3, Serine protease subunit NS2B
著者Huber, S, Heine, A, Steinmetzer, T.
登録日2021-08-11
公開日2022-08-24
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Structure-Based Optimization and Characterization of Macrocyclic Zika Virus NS2B-NS3 Protease Inhibitors.
J.Med.Chem., 65, 2022
5YOF
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BU of 5yof by Molmil
Crystal structure of zika virus NS3 protease in complex with a dipeptide inhibitor
分子名称: (S)-2-acetamido-6-amino-N-((S)-5-guanidino-1-oxopentan-2-yl)hexanamide, NS2B cofactor, NS3 Protease
著者Phoo, W.W, Zhang, Z.Z.
登録日2017-10-27
公開日2018-03-21
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (1.51 Å)
主引用文献Structural Insights into the Inhibition of Zika Virus NS2B-NS3 Protease by a Small-Molecule Inhibitor
Structure, 26, 2018
7VMV
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BU of 7vmv by Molmil
Crystal structure of Dengue NS2B-NS3 Protease after secondary cleavage
分子名称: Core protein
著者Quek, J.P.
登録日2021-10-09
公開日2022-07-06
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.351 Å)
主引用文献Dynamic Interactions of Post Cleaved NS2B Cofactor and NS3 Protease Identified by Integrative Structural Approaches.
Viruses, 14, 2022
5YOD
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BU of 5yod by Molmil
Crystal structure of zika virus NS3 protease in complex with a small molecule inhibitor
分子名称: BENZOIC ACID, NS2B cofactor, NS3 protease
著者Phoo, W.W, Zhang, Z.Z.
登録日2017-10-27
公開日2018-03-21
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural Insights into the Inhibition of Zika Virus NS2B-NS3 Protease by a Small-Molecule Inhibitor
Structure, 26, 2018
5YVJ
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BU of 5yvj by Molmil
Crystal structure of full length NS2B47-NS3 (gD4NS2BNS3) from Dengue virus 4 in open conformation
分子名称: GLYCEROL, Genome polyprotein
著者Phoo, W.W, El Sahili, A.
登録日2017-11-26
公開日2018-11-28
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.508 Å)
主引用文献Crystal structures of unlinked full length NS3 from Dengue virus provide insights into dynamics of protease domain
To Be Published
5YVV
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BU of 5yvv by Molmil
Crystal structure of full length NS3 protein (gD4NS2BNS3) from DENV4 in closed conformation
分子名称: Genome polyprotein
著者PHOO, W.W, Sahili, A.E.
登録日2017-11-27
公開日2018-12-05
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.097 Å)
主引用文献Crystal structures of unlinked full length NS3 from Dengue virus provide insights into dynamics of protease domain
To Be Published
5YVW
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BU of 5yvw by Molmil
Crystal structure of full length NS3 protein (eD4NS2BNS3) from DENV4 in closed conformation
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Genome polyprotein
著者PHOO, W.W, El Sahili, A.
登録日2017-11-27
公開日2018-12-05
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Crystal structures of unlinked full length NS3 from Dengue virus provide insights into dynamics of protease domain
To Be Published
5YVY
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BU of 5yvy by Molmil
Crystal structure of unlinked full length NS3 protein (eD4NS2BNS3) from DENV4 in closed conformation
分子名称: Genome polyprotein
著者PHOO, W.W, El Sahili, A.
登録日2017-11-27
公開日2018-11-28
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Crystal structures of unlinked full length NS3 from Dengue virus provide insights into dynamics of protease domain
To Be Published
5ZOB
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BU of 5zob by Molmil
Crystal structure of Zika NS3 protease with 4-guanidinomethyl-phenylacetyl-Arg-Arg-Arg-4-amidinobenzylamide
分子名称: 4-guanidinomethyl-phenylacetyl-Arg-Arg-Arg-4-amidinobenzylamide, NS3 protease, Serine protease subunit NS2B
著者Phoo, W.W, Wirawan, M.
登録日2018-04-12
公開日2018-10-17
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structures of Zika virus NS2B-NS3 protease in complex with peptidomimetic inhibitors.
Antiviral Res., 160, 2018

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件を2025-07-09に公開中

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