7PFY

Crystal Structure of Unlinked NS2B-NS3 Protease from Zika Virus in Complex with Inhibitor MI-2241

Summary for 7PFY

Entry DOI	10.2210/pdb7pfy/pdb
Descriptor	Serine protease subunit NS2B, Serine protease NS3, Inhibitor MI-2241, ... (4 entities in total)
Functional Keywords	flavivirin, serine protease, viral protein, ns2b-ns3, zika virus
Biological source	Zika virus (ZIKV) More
Total number of polymer chains	3
Total formula weight	25576.82
Authors	Huber, S.,Heine, A.,Steinmetzer, T. (deposition date: 2021-08-12, release date: 2022-08-24, Last modification date: 2024-01-31)
Primary citation	Huber, S.,Braun, N.J.,Schmacke, L.C.,Quek, J.P.,Murra, R.,Bender, D.,Hildt, E.,Luo, D.,Heine, A.,Steinmetzer, T. Structure-Based Optimization and Characterization of Macrocyclic Zika Virus NS2B-NS3 Protease Inhibitors. J.Med.Chem., 65:6555-6572, 2022 Cited by PubMed: 35475620 DOI: 10.1021/acs.jmedchem.1c01860 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.38 Å)

Structure validation