7PGC
Crystal Structure of Unlinked NS2B-NS3 Protease from Zika Virus in Complex with Inhibitor MI-2191
Summary for 7PGC
| Entry DOI | 10.2210/pdb7pgc/pdb |
| Descriptor | Serine protease subunit NS2B, Serine protease NS3, Inhibitor MI-2191, ... (4 entities in total) |
| Functional Keywords | flavivirin, serine protease, viral protein, ns2b-ns3, zika virus |
| Biological source | Zika virus (ZIKV) More |
| Total number of polymer chains | 3 |
| Total formula weight | 25657.94 |
| Authors | Huber, S.,Heine, A.,Steinmetzer, T. (deposition date: 2021-08-13, release date: 2022-08-24, Last modification date: 2024-01-31) |
| Primary citation | Huber, S.,Braun, N.J.,Schmacke, L.C.,Quek, J.P.,Murra, R.,Bender, D.,Hildt, E.,Luo, D.,Heine, A.,Steinmetzer, T. Structure-Based Optimization and Characterization of Macrocyclic Zika Virus NS2B-NS3 Protease Inhibitors. J.Med.Chem., 65:6555-6572, 2022 Cited by PubMed: 35475620DOI: 10.1021/acs.jmedchem.1c01860 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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