7X01

Cryo-EM Structure of Chikungunya Virus Nonstructural Protein 1 with inhibitor FHA

Summary for 7X01

Entry DOI	10.2210/pdb7x01/pdb
EMDB information	32914
Descriptor	mRNA-capping enzyme nsP1, ZINC ION, (1R,2S,3S,4R,5R)-3-(6-aminopurin-9-yl)-4-fluoranyl-5-(2-hydroxyethyl)cyclopentane-1,2-diol (3 entities in total)
Functional Keywords	nonstructural protein, chikungunya virus, rna cap, inhibitor, viral protein
Biological source	Chikungunya virus strain S27-African prototype
Total number of polymer chains	12
Total formula weight	749030.81
Authors	Zhang, K.,Law, M.C.Y.,Nguyen, T.M.,Tan, Y.B.,Wirawan, M.,Law, Y.S.,Luo, D.H. (deposition date: 2022-02-20, release date: 2022-08-10)
Primary citation	Zhang, K.,Law, M.C.Y.,Nguyen, T.M.,Tan, Y.B.,Wirawan, M.,Law, Y.S.,Jeong, L.S.,Luo, D. Molecular basis of specific viral RNA recognition and 5'-end capping by the Chikungunya virus nsP1. Cell Rep, 40:111133-111133, 2022 Cited by PubMed: 35905713 DOI: 10.1016/j.celrep.2022.111133 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.62 Å)

Structure validation