7X01

Cryo-EM Structure of Chikungunya Virus Nonstructural Protein 1 with inhibitor FHA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E...	mRNA-capping enzyme nsP1	polymer	552	62056.5	12	UniProt (Q8JUX6) Pfam (PF01660) In PDB	Chikungunya virus strain S27-African prototype	Non-structural protein 1
2	H, I, J, K, L...	ZINC ION	non-polymer		65.4	12	Chemie (ZN)
3	H, I, J, K, L...	(1R,2S,3S,4R,5R)-3-(6-aminopurin-9-yl)-4-fluoranyl-5-(2-hydroxyethyl)cyclopentane-1,2-diol	non-polymer		297.3	12	Chemie (7XQ)

Sequence modifications

A, B, C, D, E, F, G, H, I, J, K, L: 1 - 516 (UniProt: Q8JUX6)

PDB	External Database	Details
Gly 517	-	expression tag
Gly 518	-	expression tag
Gly 519	-	expression tag
Gly 520	-	expression tag
Ser 521	-	expression tag
Trp 522	-	expression tag
Ser 523	-	expression tag
His 524	-	expression tag
Pro 525	-	expression tag
Gln 526	-	expression tag
Phe 527	-	expression tag
Glu 528	-	expression tag
Lys 529	-	expression tag
Met 530	-	expression tag
Asp 531	-	expression tag
Tyr 532	-	expression tag
Lys 533	-	expression tag
Asp 534	-	expression tag
His 535	-	expression tag
Asp 536	-	expression tag
Gly 537	-	expression tag
Asp 538	-	expression tag
Tyr 539	-	expression tag
Lys 540	-	expression tag
Asp 541	-	expression tag
His 542	-	expression tag
Asp 543	-	expression tag
Ile 544	-	expression tag
Asp 545	-	expression tag
Tyr 546	-	expression tag
Lys 547	-	expression tag
Asp 548	-	expression tag
Asp 549	-	expression tag
Asp 550	-	expression tag
Asp 551	-	expression tag
Lys 552	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	744678.5
Non-Polymers*	Number of molecules	24
	Total formula weight	4352.3
All*	Total formula weight	749030.8

*Water molecules are not included.