7X01

Cryo-EM Structure of Chikungunya Virus Nonstructural Protein 1 with inhibitor FHA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0006396	biological_process	RNA processing
A	0008174	molecular_function	mRNA methyltransferase activity
A	0016556	biological_process	mRNA modification
B	0003723	molecular_function	RNA binding
B	0006396	biological_process	RNA processing
B	0008174	molecular_function	mRNA methyltransferase activity
B	0016556	biological_process	mRNA modification
C	0003723	molecular_function	RNA binding
C	0006396	biological_process	RNA processing
C	0008174	molecular_function	mRNA methyltransferase activity
C	0016556	biological_process	mRNA modification
D	0003723	molecular_function	RNA binding
D	0006396	biological_process	RNA processing
D	0008174	molecular_function	mRNA methyltransferase activity
D	0016556	biological_process	mRNA modification
E	0003723	molecular_function	RNA binding
E	0006396	biological_process	RNA processing
E	0008174	molecular_function	mRNA methyltransferase activity
E	0016556	biological_process	mRNA modification
F	0003723	molecular_function	RNA binding
F	0006396	biological_process	RNA processing
F	0008174	molecular_function	mRNA methyltransferase activity
F	0016556	biological_process	mRNA modification
G	0003723	molecular_function	RNA binding
G	0006396	biological_process	RNA processing
G	0008174	molecular_function	mRNA methyltransferase activity
G	0016556	biological_process	mRNA modification
H	0003723	molecular_function	RNA binding
H	0006396	biological_process	RNA processing
H	0008174	molecular_function	mRNA methyltransferase activity
H	0016556	biological_process	mRNA modification
I	0003723	molecular_function	RNA binding
I	0006396	biological_process	RNA processing
I	0008174	molecular_function	mRNA methyltransferase activity
I	0016556	biological_process	mRNA modification
J	0003723	molecular_function	RNA binding
J	0006396	biological_process	RNA processing
J	0008174	molecular_function	mRNA methyltransferase activity
J	0016556	biological_process	mRNA modification
K	0003723	molecular_function	RNA binding
K	0006396	biological_process	RNA processing
K	0008174	molecular_function	mRNA methyltransferase activity
K	0016556	biological_process	mRNA modification
L	0003723	molecular_function	RNA binding
L	0006396	biological_process	RNA processing
L	0008174	molecular_function	mRNA methyltransferase activity
L	0016556	biological_process	mRNA modification

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	ACT_SITE: For mRNA-capping enzyme nsP1 activity => ECO:0000269|PubMed:33730549

Chain	Residue	Details
A	HIS37
J	HIS37
K	HIS37
L	HIS37
B	HIS37
C	HIS37
D	HIS37
E	HIS37
F	HIS37
G	HIS37
H	HIS37
I	HIS37

---

site_id	SWS_FT_FI2
Number of Residues	48
Details	BINDING: BINDING => ECO:0000269|PubMed:33730549

Chain	Residue	Details
A	HIS79
C	GLU129
C	CYS134
C	CYS141
D	HIS79
D	GLU129
D	CYS134
D	CYS141
E	HIS79
E	GLU129
E	CYS134
A	GLU129
E	CYS141
F	HIS79
F	GLU129
F	CYS134
F	CYS141
G	HIS79
G	GLU129
G	CYS134
G	CYS141
H	HIS79
A	CYS134
H	GLU129
H	CYS134
H	CYS141
I	HIS79
I	GLU129
I	CYS134
I	CYS141
J	HIS79
J	GLU129
J	CYS134
A	CYS141
J	CYS141
K	HIS79
K	GLU129
K	CYS134
K	CYS141
L	HIS79
L	GLU129
L	CYS134
L	CYS141
B	HIS79
B	GLU129
B	CYS134
B	CYS141
C	HIS79

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	SITE: Involved in the phosphoramide link with 7-methyl-GMP => ECO:0000250|UniProtKB:P27282

Chain	Residue	Details
A	HIS37
J	HIS37
K	HIS37
L	HIS37
B	HIS37
C	HIS37
D	HIS37
E	HIS37
F	HIS37
G	HIS37
H	HIS37
I	HIS37

---

site_id	SWS_FT_FI4
Number of Residues	24
Details	LIPID: S-palmitoyl cysteine; by host => ECO:0000305|PubMed:30404808

Chain	Residue	Details
A	CYS417
E	CYS419
F	CYS417
F	CYS419
G	CYS417
G	CYS419
H	CYS417
H	CYS419
I	CYS417
I	CYS419
J	CYS417
A	CYS419
J	CYS419
K	CYS417
K	CYS419
L	CYS417
L	CYS419
B	CYS417
B	CYS419
C	CYS417
C	CYS419
D	CYS417
D	CYS419
E	CYS417

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