9AYH
| Cryo-EM structure of human Cav3.2 with TTA-A2 | 分子名称: | 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-(4-cyclopropylphenyl)-N-{(1R)-1-[5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethyl}acetamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Fan, X, Huang, J, Yan, N. | 登録日 | 2024-03-07 | 公開日 | 2024-04-24 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural basis for human Ca v 3.2 inhibition by selective antagonists. Cell Res., 34, 2024
|
|
9AYK
| Cryo-EM structure of human Cav3.2 with ML218 | 分子名称: | 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 3,5-dichloro-N-{[(1R,5S,6r)-3-(3,3-dimethylbutyl)-3-azabicyclo[3.1.0]hexan-6-yl]methyl}benzamide, ... | 著者 | Fan, X, Huang, J, Yan, N. | 登録日 | 2024-03-08 | 公開日 | 2024-04-24 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis for human Ca v 3.2 inhibition by selective antagonists. Cell Res., 34, 2024
|
|
8VE0
| Human transthyretin covalently modified with A2-derived stilbene in the compressed conformation | 分子名称: | 3-(dimethylamino)-5-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]benzoic acid, Transthyretin | 著者 | Basanta, B, Nugroho, K, Yan, N, Kline, G.M, Tsai, F.J, Wu, M, Kelly, J.W, Lander, G.C. | 登録日 | 2023-12-18 | 公開日 | 2024-01-31 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | The conformational landscape of human transthyretin revealed by cryo-EM To Be Published
|
|
2NRF
| Crystal Structure of GlpG, a Rhomboid family intramembrane protease | 分子名称: | Protein GlpG | 著者 | Wu, Z, Yan, N, Feng, L, Yan, H, Gu, L, Shi, Y. | 登録日 | 2006-11-02 | 公開日 | 2006-11-14 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry. Nat.Struct.Mol.Biol., 13, 2006
|
|
8VE6
| (Biarylamine-FT2-WT)1(C10A)3-human transthyretin in the frayed conformation | 分子名称: | 2-[(3,5-DICHLORO-4-TRIOXIDANYLPHENYL)AMINO]BENZOIC ACID, Transthyretin | 著者 | Basanta, B, Nugroho, K, Yan, N, Kline, G.M, Tsai, F.J, Wu, M, Kelly, J.W, Lander, G.C. | 登録日 | 2023-12-18 | 公開日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | The conformational landscape of human transthyretin revealed by cryo-EM To Be Published
|
|
8VE2
| Unliganded human transthyretin in the canonical conformation | 分子名称: | Transthyretin | 著者 | Basanta, B, Nugroho, K, Yan, N, Kline, G.M, Tsai, F.J, Wu, M, Kelly, J.W, Lander, G.C. | 登録日 | 2023-12-18 | 公開日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | The conformational landscape of human transthyretin revealed by cryo-EM To Be Published
|
|
8VE3
| Unliganded human transthyretin in the compressed conformation | 分子名称: | Transthyretin | 著者 | Basanta, B, Nugroho, K, Yan, N, Kline, G.M, Tsai, F.J, Wu, M, Kelly, J.W, Lander, G.C. | 登録日 | 2023-12-18 | 公開日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | The conformational landscape of human transthyretin revealed by cryo-EM To Be Published
|
|
8VE1
| Human transthyretin covalently modified with A2-derived stilbene in the canonical conformation | 分子名称: | 3-(dimethylamino)-5-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]benzoic acid, Transthyretin | 著者 | Basanta, B, Nugroho, K, Yan, N, Kline, G.M, Tsai, F.J, Wu, M, Kelly, J.W, Lander, G.C. | 登録日 | 2023-12-18 | 公開日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | The conformational landscape of human transthyretin revealed by cryo-EM To Be Published
|
|
8VE5
| (Biarylamine-FT2-WT)1(C10A)3-human transthyretin in the compressed conformation | 分子名称: | 2-[(3,5-DICHLORO-4-TRIOXIDANYLPHENYL)AMINO]BENZOIC ACID, Transthyretin | 著者 | Basanta, B, Nugroho, K, Yan, N, Kline, G.M, Tsai, F.J, Wu, M, Kelly, J.W, Lander, G.C. | 登録日 | 2023-12-18 | 公開日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | The conformational landscape of human transthyretin revealed by cryo-EM To Be Published
|
|
8VE4
| Unliganded human transthyretin in the frayed conformation | 分子名称: | Transthyretin | 著者 | Basanta, B, Nugroho, K, Yan, N, Kline, G.M, Tsai, F.J, Wu, M, Kelly, J.W, Lander, G.C. | 登録日 | 2023-12-18 | 公開日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | The conformational landscape of human transthyretin revealed by cryo-EM To Be Published
|
|
7UHG
| Human L-type voltage-gated calcium channel Cav1.3 at 3.0 Angstrom resolution | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Gao, S, Yao, X, Yan, N. | 登録日 | 2022-03-26 | 公開日 | 2022-05-11 | 最終更新日 | 2022-10-12 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis for pore blockade of human voltage-gated calcium channel Ca v 1.3 by motion sickness drug cinnarizine. Cell Res., 32, 2022
|
|
7UHF
| Human L-type voltage-gated calcium channel Cav1.3 in the presence of cinnarizine at 3.1 Angstrom resolution | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 1-(diphenylmethyl)-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Gao, S, Yao, X, Yan, N. | 登録日 | 2022-03-26 | 公開日 | 2022-05-11 | 最終更新日 | 2022-10-12 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural basis for pore blockade of human voltage-gated calcium channel Ca v 1.3 by motion sickness drug cinnarizine. Cell Res., 32, 2022
|
|
4ZWB
| Crystal structure of maltose-bound human GLUT3 in the outward-occluded conformation at 2.4 angstrom | 分子名称: | Solute carrier family 2, facilitated glucose transporter member 3, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | 著者 | Deng, D, Sun, P.C, Yan, C.Y, Yan, N. | 登録日 | 2015-05-19 | 公開日 | 2015-07-22 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Molecular basis of ligand recognition and transport by glucose transporters Nature, 526, 2015
|
|
4ZWC
| Crystal structure of maltose-bound human GLUT3 in the outward-open conformation at 2.6 angstrom | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Solute carrier family 2, facilitated glucose transporter member 3, ... | 著者 | Deng, D, Sun, P.C, Yan, C.Y, Yan, N. | 登録日 | 2015-05-19 | 公開日 | 2015-07-22 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Molecular basis of ligand recognition and transport by glucose transporters Nature, 526, 2015
|
|
4ZW9
| Crystal structure of human GLUT3 bound to D-glucose in the outward-occluded conformation at 1.5 angstrom | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Solute carrier family 2, facilitated glucose transporter member 3, ... | 著者 | Deng, D, Sun, P.C, Yan, C.Y, Yan, N. | 登録日 | 2015-05-19 | 公開日 | 2015-07-22 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.502 Å) | 主引用文献 | Molecular basis of ligand recognition and transport by glucose transporters Nature, 526, 2015
|
|
3B4R
| Site-2 Protease from Methanocaldococcus jannaschii | 分子名称: | Putative zinc metalloprotease MJ0392, ZINC ION | 著者 | Jeffrey, P.D, Feng, L, Yan, H, Wu, Z, Yan, N, Wang, Z, Shi, Y. | 登録日 | 2007-10-24 | 公開日 | 2008-01-15 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Structure of a site-2 protease family intramembrane metalloprotease. Science, 318, 2007
|
|
8AMX
| AQP7 dimer of tetramers_D4 | 分子名称: | Aquaporin-7 | 著者 | Huang, P, Venskutonyte, R, Fan, X, Li, P, Yan, N, Gourdon, P, Lindkvist-Petersson, K. | 登録日 | 2022-08-04 | 公開日 | 2023-02-15 | 実験手法 | ELECTRON MICROSCOPY (2.55 Å) | 主引用文献 | Cryo-EM structure supports a role of AQP7 as a junction protein. Nat Commun, 14, 2023
|
|
8AMW
| AQP7 dimer of tetramers_C1 | 分子名称: | Aquaporin-7, GLYCEROL | 著者 | Huang, P, Venskutonyte, R, Fan, X, Li, P, Yan, N, Gourdon, P, Lindkvist-Petersson, K. | 登録日 | 2022-08-04 | 公開日 | 2023-02-15 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Cryo-EM structure supports a role of AQP7 as a junction protein. Nat Commun, 14, 2023
|
|
1OZJ
| Crystal structure of Smad3-MH1 bound to DNA at 2.4 A resolution | 分子名称: | SMAD 3, Smad binding element, ZINC ION | 著者 | Chai, J, Wu, J.-W, Yan, N, Massague, J, Pavletich, N.P, Shi, Y. | 登録日 | 2003-04-09 | 公開日 | 2004-03-23 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Features of a Smad3 MH1-DNA complex. Roles of water and zinc in DNA binding. J.Biol.Chem., 278, 2003
|
|
1Q4Q
| Crystal structure of a DIAP1-Dronc complex | 分子名称: | Apoptosis 1 inhibitor, Nedd2-like caspase CG8091-PA, ZINC ION | 著者 | Chai, J, Yan, N, Shi, Y. | 登録日 | 2003-08-04 | 公開日 | 2003-11-04 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Molecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination Nat.Struct.Biol., 10, 2003
|
|
4DXW
| Crystal structure of NavRh, a voltage-gated sodium channel | 分子名称: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, Ion transport protein, ... | 著者 | Zhang, X, Ren, W.L, Yan, C.Y, Wang, J.W, Yan, N. | 登録日 | 2012-02-28 | 公開日 | 2012-05-23 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (3.052 Å) | 主引用文献 | Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel Nature, 486, 2012
|
|
6DS5
| Cryo EM structure of human SEIPIN | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Seipin | 著者 | Yan, R.H, Qian, H.W, Yan, N, Yang, H.Y. | 登録日 | 2018-06-13 | 公開日 | 2018-10-24 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Human SEIPIN Binds Anionic Phospholipids. Dev. Cell, 47, 2018
|
|
4YHC
| Crystal structure of the WD40 domain of SCAP from fission yeast | 分子名称: | CITRIC ACID, Sterol regulatory element-binding protein cleavage-activating protein | 著者 | Gong, X, Li, J.X, Wu, J.P, Yan, C.Y, Yan, N. | 登録日 | 2015-02-27 | 公開日 | 2015-04-01 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structure of the WD40 domain of SCAP from fission yeast reveals the molecular basis for SREBP recognition. Cell Res., 25, 2015
|
|
8E5A
| Human L-type voltage-gated calcium channel Cav1.3 treated with 1.4 mM Sofosbuvir at 3.3 Angstrom resolution | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Gao, S, Yao, X, Yan, N. | 登録日 | 2022-08-20 | 公開日 | 2022-12-07 | 最終更新日 | 2022-12-21 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural basis for the severe adverse interaction of sofosbuvir and amiodarone on L-type Ca v channels. Cell, 185, 2022
|
|
8E57
| Rabbit L-type voltage-gated calcium channel Cav1.1 in the presence of Amiodarone and 100 microM MNI-1 at 2.8 Angstrom resolution | 分子名称: | (2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanone, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Gao, S, Yao, X, Yan, N. | 登録日 | 2022-08-20 | 公開日 | 2022-12-07 | 最終更新日 | 2022-12-21 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural basis for the severe adverse interaction of sofosbuvir and amiodarone on L-type Ca v channels. Cell, 185, 2022
|
|