9AYH

Cryo-EM structure of human Cav3.2 with TTA-A2

This is a non-PDB format compatible entry.

Summary for 9AYH

• Entry DOI: 10.2210/pdb9ayh/pdb
• EMDB information: 43992
• Descriptor: Voltage-dependent T-type calcium channel subunit alpha-1H, 2-(4-cyclopropylphenyl)-N-{(1R)-1-[5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethyl}acetamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: cav3.2, voltage gated calcium channel, cryo-em, transport protein, tta-a2
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 1
• Total formula weight: 240827.73

Authors

Fan, X.,Huang, J.,Yan, N. (deposition date: 2024-03-07, release date: 2024-04-24, Last modification date: 2024-06-12)

• Primary citation: Huang, J.,Fan, X.,Jin, X.,Lyu, C.,Guo, Q.,Liu, T.,Chen, J.,Davakan, A.,Lory, P.,Yan, N.; Structural basis for human Ca v 3.2 inhibition by selective antagonists.; Cell Res., 34:440-450, 2024; PubMed: 38605177; DOI: 10.1038/s41422-024-00959-8

Experimental method

ELECTRON MICROSCOPY (3.1 Å)