5JKE
| Crystal structure of human IZUMO1-JUNO complex (crystal form 3) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Izumo sperm-egg fusion protein 1, ... | 著者 | Ohto, U, Ishida, H, Shimizu, T. | 登録日 | 2016-04-26 | 公開日 | 2016-06-22 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.86 Å) | 主引用文献 | Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization Nature, 534, 2016
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8WX2
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8WX3
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8WX5
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8WX4
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8YRJ
| Mouse Fc epsilon RI | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, High affinity immunoglobulin epsilon receptor subunit alpha, High affinity immunoglobulin epsilon receptor subunit beta, ... | 著者 | Zhang, Z, Yui, M, Ohto, U, Shimizu, T. | 登録日 | 2024-03-21 | 公開日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (3.87 Å) | 主引用文献 | Mouse Fc epsilon RI To Be Published
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5ZLN
| Crystal structure of mouse TLR9 in complex with two DNAs (CpG DNA and TCGCCA DNA) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DNA (5'-D(*AP*GP*GP*CP*GP*TP*TP*TP*TP*T)-3'), ... | 著者 | Ishida, H, Ohto, U, Shimizu, T. | 登録日 | 2018-03-28 | 公開日 | 2018-04-25 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural basis for species-specific activation of mouse Toll-like receptor 9 FEBS Lett., 592, 2018
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6LVY
| Crystal structure of TLR7/Cpd-2 (SM-360320) complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 6-azanyl-2-(2-methoxyethoxy)-9-(phenylmethyl)-7H-purin-8-one, ... | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | 登録日 | 2020-02-06 | 公開日 | 2020-11-11 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural analysis reveals TLR7 dynamics underlying antagonism. Nat Commun, 11, 2020
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6LW0
| Crystal structure of TLR7/Cpd-6 (DSR-139293) complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-ethoxy-8-(5-fluoranylpyridin-3-yl)-9-[[4-[[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]methyl]phenyl]methyl]purin-6-amine, ... | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | 登録日 | 2020-02-06 | 公開日 | 2020-11-11 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural analysis reveals TLR7 dynamics underlying antagonism. Nat Commun, 11, 2020
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4R6A
| Crystal structure of human TLR8 in complex with Hybrid-2 | 分子名称: | 1-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, Toll-like receptor 8, ... | 著者 | Tanji, H, Ohto, U, Shimizu, T. | 登録日 | 2014-08-22 | 公開日 | 2015-08-26 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Hybrid-2: AnImidazoquinoline Dual Toll-like receptor 7/8 Agonist that Potently Activates Cytokine Production by Human Newborn and Adult Leukocytes To be Published
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6LVZ
| Crystal structure of TLR7/Cpd-3 (SM-394830) complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 6-azanyl-2-(2-methoxyethoxy)-9-(pyridin-3-ylmethyl)-7H-purin-8-one, ... | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | 登録日 | 2020-02-06 | 公開日 | 2020-11-11 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.83 Å) | 主引用文献 | Structural analysis reveals TLR7 dynamics underlying antagonism. Nat Commun, 11, 2020
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6LVX
| Crystal structure of TLR7/Cpd-1 (SM-374527) complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 6-azanyl-2-butoxy-9-(phenylmethyl)-7H-purin-8-one, ... | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | 登録日 | 2020-02-06 | 公開日 | 2020-11-11 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.77 Å) | 主引用文献 | Structural analysis reveals TLR7 dynamics underlying antagonism. Nat Commun, 11, 2020
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7WM4
| Cryo-EM structure of tetrameric TLR3 in complex with dsRNA (90 bp) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, RNA (81-MER), ... | 著者 | Sakaniwa, K, Ohto, U, Shimizu, T. | 登録日 | 2022-01-14 | 公開日 | 2023-01-25 | 最終更新日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transduction. Nat Commun, 14, 2023
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4QC0
| Crystal structure of human TLR8 in complex with XG-1-236 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-butyl-2H-pyrazolo[3,4-c]quinolin-4-amine, Toll-like receptor 8, ... | 著者 | Tanji, H, Ohto, U, Shimizu, T. | 登録日 | 2014-05-09 | 公開日 | 2014-10-22 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Determinants of Activity at Human Toll-like Receptors 7 and 8: Quantitative Structure-Activity Relationship (QSAR) of Diverse Heterocyclic Scaffolds J.Med.Chem., 57, 2014
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4QBZ
| Crystal structure of human TLR8 in complex with DS-802 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-butyl[1,3]oxazolo[4,5-c]quinolin-4-amine, ... | 著者 | Tanji, H, Ohto, U, Shimizu, T. | 登録日 | 2014-05-09 | 公開日 | 2014-10-22 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Determinants of Activity at Human Toll-like Receptors 7 and 8: Quantitative Structure-Activity Relationship (QSAR) of Diverse Heterocyclic Scaffolds J.Med.Chem., 57, 2014
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6LW1
| Cryo-EM structure of TLR7/Cpd-7 (DSR-139970) complex in open form | 分子名称: | 2-ethoxy-8-(5-fluoranylpyridin-3-yl)-6-methyl-9-[[4-[[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]methyl]phenyl]methyl]purine, Toll-like receptor 7 | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | 登録日 | 2020-02-06 | 公開日 | 2020-11-11 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural analysis reveals TLR7 dynamics underlying antagonism. Nat Commun, 11, 2020
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1GD2
| CRYSTAL STRUCTURE OF BZIP TRANSCRIPTION FACTOR PAP1 BOUND TO DNA | 分子名称: | DNA (5'-D(*AP*GP*GP*TP*TP*AP*CP*GP*TP*AP*AP*CP*C)-3'), TRANSCRIPTION FACTOR PAP1 | 著者 | Fujii, Y, Shimizu, T, Toda, T, Yanagida, M, Hakoshima, T. | 登録日 | 2000-08-25 | 公開日 | 2000-10-02 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural basis for the diversity of DNA recognition by bZIP transcription factors. Nat.Struct.Biol., 7, 2000
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7WGE
| Human NLRP1 complexed with thioredoxin | 分子名称: | MAGNESIUM ION, NACHT, LRR and PYD domains-containing protein 1, ... | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | 登録日 | 2021-12-28 | 公開日 | 2023-07-05 | 最終更新日 | 2023-10-18 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural basis for thioredoxin-mediated suppression of NLRP1 inflammasome. Nature, 622, 2023
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5GMH
| Crystal structure of monkey TLR7 in complex with R848 | 分子名称: | 1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | 登録日 | 2016-07-14 | 公開日 | 2016-11-02 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA Immunity, 45, 2016
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1GLN
| ARCHITECTURES OF CLASS-DEFINING AND SPECIFIC DOMAINS OF GLUTAMYL-TRNA SYNTHETASE | 分子名称: | GLUTAMYL-TRNA SYNTHETASE | 著者 | Nureki, O, Vassylyev, D.G, Katayanagi, K, Shimizu, T, Sekine, S, Kigawa, T, Miyazawa, T, Yokoyama, S, Morikawa, K, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 1994-07-20 | 公開日 | 1995-10-15 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Architectures of class-defining and specific domains of glutamyl-tRNA synthetase. Science, 267, 1995
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5H6K
| DNA targeting ADP-ribosyltransferase Pierisin-1 | 分子名称: | 1,2-ETHANEDIOL, Pierisin-1 | 著者 | Oda, T, Hirabayashi, H, Shikauchi, G, Takamura, R, Hiraga, K, Minami, H, Hashimoto, H, Yamamoto, M, Wakabayashi, K, Sugimura, T, Shimizu, T, Sato, M. | 登録日 | 2016-11-14 | 公開日 | 2017-08-09 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural basis of autoinhibition and activation of the DNA-targeting ADP-ribosyltransferase pierisin-1 J. Biol. Chem., 292, 2017
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5H6N
| DNA targeting ADP-ribosyltransferase Pierisin-1, autoinhibitory form | 分子名称: | Pierisin-1 | 著者 | Oda, T, Hirabayashi, H, Shikauchi, G, Takamura, R, Hiraga, K, Minami, H, Hashimoto, H, Yamamoto, M, Wakabayashi, K, Sugimura, T, Shimizu, T, Sato, M. | 登録日 | 2016-11-14 | 公開日 | 2017-08-09 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural basis of autoinhibition and activation of the DNA-targeting ADP-ribosyltransferase pierisin-1 J. Biol. Chem., 292, 2017
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5H6L
| DNA targeting ADP-ribosyltransferase Pierisin-1 in complex with beta-NAD+ | 分子名称: | 1,2-ETHANEDIOL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Pierisin-1 | 著者 | Oda, T, Hirabayashi, H, Shikauchi, G, Takamura, R, Hiraga, K, Minami, H, Hashimoto, H, Yamamoto, M, Wakabayashi, K, Sugimura, T, Shimizu, T, Sato, M. | 登録日 | 2016-11-14 | 公開日 | 2017-08-09 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural basis of autoinhibition and activation of the DNA-targeting ADP-ribosyltransferase pierisin-1 J. Biol. Chem., 292, 2017
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5GMF
| Crystal structure of monkey TLR7 in complex with guanosine and polyU | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | 登録日 | 2016-07-14 | 公開日 | 2016-11-02 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA Immunity, 45, 2016
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5GMG
| Crystal structure of monkey TLR7 in complex with loxoribine and polyU | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-azanyl-9-[(2~{R},3~{R},4~{S},5~{R})-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]-7-prop-2-enyl-1~{H}-purine-6,8-dione, ... | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | 登録日 | 2016-07-14 | 公開日 | 2016-11-02 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA Immunity, 45, 2016
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