8GJX
| Structure of the human STING receptor bound to 2'3'-cUA | 分子名称: | 2'3'-cUA, Stimulator of interferon genes protein | 著者 | Morehouse, B.R, Li, Y, Slavik, K.M, Toyoda, H, Kranzusch, P.J. | 登録日 | 2023-03-16 | 公開日 | 2023-07-05 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | cGLRs are a diverse family of pattern recognition receptors in innate immunity. Cell, 186, 2023
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8GJZ
| Structure of a STING receptor from S. pistillata Sp-STING1 bound to 2'3'-cUA | 分子名称: | 2'3'-cUA, Stimulator of interferon genes protein | 著者 | Li, Y, Toyoda, H, Slavik, K.M, Morehouse, B.R, Kranzusch, P.J. | 登録日 | 2023-03-16 | 公開日 | 2023-07-05 | 最終更新日 | 2023-08-02 | 実験手法 | X-RAY DIFFRACTION (2.92 Å) | 主引用文献 | cGLRs are a diverse family of pattern recognition receptors in innate immunity. Cell, 186, 2023
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8G9Q
| Tricomplex of Compound-1, KRAS G12C, and CypA | 分子名称: | GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | 著者 | Tomlinson, A.C.A, Chen, A, Knox, J.E, Yano, J.K. | 登録日 | 2023-02-21 | 公開日 | 2023-08-16 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS. Science, 381, 2023
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8G9P
| Tricomplex of RMC-4998, KRAS G12C, and CypA | 分子名称: | (2S)-2-{(5S)-7-[(2E)-4-(dimethylamino)-4-methylpent-2-enoyl]-1-oxo-2,7-diazaspiro[4.4]nonan-2-yl}-N-[(1P,8S,10R,14S,21M)-22-ethyl-21-{2-[(1S)-1-methoxyethyl]pyridin-3-yl}-18,18-dimethyl-9,15-dioxo-16-oxa-10,22,28-triazapentacyclo[18.5.2.1~2,6~.1~10,14~.0~23,27~]nonacosa-1(25),2(29),3,5,20,23,26-heptaen-8-yl]-3-methylbutanamide (non-preferred name), CHLORIDE ION, GTPase KRas, ... | 著者 | Tomlinson, A.C.A, Saldajeno-Concar, M, Knox, J.E, Yano, J.K. | 登録日 | 2023-02-21 | 公開日 | 2023-08-16 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS. Science, 381, 2023
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7F5P
| The crystal structure of VyPAL2-C214A, a dead mutant of VyPAL2 peptide asparaginyl ligase in form I | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Peptide Asparaginyl Ligases, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Hu, S, Sahili, A, Lescar, J. | 登録日 | 2021-06-22 | 公開日 | 2022-06-29 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural basis for proenzyme maturation, substrate recognition, and ligation by a hyperactive peptide asparaginyl ligase. Plant Cell, 34, 2022
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7F5J
| The crystal structure of VyPAL2-I244V, a more efficient mutant of VyPAL2 peptide asparaginyl ligase in its active enzyme form | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Hu, S, Sahili, A, Lescar, J. | 登録日 | 2021-06-22 | 公開日 | 2022-06-29 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.593 Å) | 主引用文献 | Structural basis for proenzyme maturation, substrate recognition, and ligation by a hyperactive peptide asparaginyl ligase. Plant Cell, 34, 2022
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7F5Q
| The crystal structure of VyPAL2 peptide asparaginyl ligase in its active enzyme form | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Hu, S, Sahili, A, Lescar, J. | 登録日 | 2021-06-22 | 公開日 | 2022-06-29 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural basis for proenzyme maturation, substrate recognition, and ligation by a hyperactive peptide asparaginyl ligase. Plant Cell, 34, 2022
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7FA0
| The crystal structure of VyPAL2-C214A, a dead mutant of VyPAL2 peptide asparaginyl ligase in form II | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Peptide Asparaginyl Ligases, ... | 著者 | Hu, S, Sahili, A, Lescar, J. | 登録日 | 2021-07-05 | 公開日 | 2022-07-13 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural basis for proenzyme maturation, substrate recognition, and ligation by a hyperactive peptide asparaginyl ligase. Plant Cell, 34, 2022
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8HT7
| The N-terminal region of Cdc6 specifically recognizes human DNA G-quadruplex | 分子名称: | DNA (5'-D(*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*TP*GP*GP*G)-3'), GLN-ALA-GLN-ALA-THR-ILE-SER-PHE-PRO-LYS-ARG-LYS-LEU-SER-TRP | 著者 | Liu, C, Zhu, G, Geng, Y, Xu, N. | 登録日 | 2022-12-20 | 公開日 | 2023-12-27 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | The N-terminal region of Cdc6 specifically recognizes human DNA G-quadruplex. Int.J.Biol.Macromol., 260, 2024
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7X28
| MERS-CoV spike complex with S41 neutralizing antibody Fab Class3 (2u1d RBD with 2Fab) | 分子名称: | Spike glycoprotein, antibody S41 heavy chain, antibody S41 light chain | 著者 | Zeng, J.W, Zhang, S.Y, Zhou, H.X, Wang, X.W. | 登録日 | 2022-02-25 | 公開日 | 2023-01-18 | 最終更新日 | 2023-01-25 | 実験手法 | ELECTRON MICROSCOPY (2.49 Å) | 主引用文献 | Cryoelectron microscopy structures of a human neutralizing antibody bound to MERS-CoV spike glycoprotein. Front Microbiol, 13, 2022
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7DUY
| Crystal structure of VIM-2 MBL in complex with 1-(2-(1H-1,2,3-triazol-1-yl)ethyl)-1H-imidazole-2-carboxylic acid | 分子名称: | 1-[2-(1,2,3-triazol-1-yl)ethyl]imidazole-2-carboxylic acid, Beta-lactamase class B VIM-2, ZINC ION | 著者 | Li, G.-B, Yan, Y.-H. | 登録日 | 2021-01-12 | 公開日 | 2022-01-19 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.999 Å) | 主引用文献 | Structure-guided optimization of 1H-imidazole-2-carboxylic acid derivatives affording potent VIM-Type metallo-beta-lactamase inhibitors. Eur.J.Med.Chem., 228, 2022
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7DV0
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7DUX
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7DV1
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7DUZ
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7DU1
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7DUE
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7DUB
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7DYY
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7DYZ
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7DZ1
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7DZ0
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7XML
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7X26
| S41 neutralizing antibody Fab(MERS-CoV) | 分子名称: | Spike glycoprotein, antibody S41 heavy chain, antibody S41 light chain | 著者 | Zeng, J.W, Zhang, S.Y, Wang, X.W. | 登録日 | 2022-02-25 | 公開日 | 2022-11-09 | 最終更新日 | 2022-11-23 | 実験手法 | ELECTRON MICROSCOPY (3.685 Å) | 主引用文献 | Cryoelectron microscopy structures of a human neutralizing antibody bound to MERS-CoV spike glycoprotein. Front Microbiol, 13, 2022
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7X2A
| MERS-CoV spike complex with S41 neutralizing antibody Fab Class1 (1u2d RBD with 1Fab) | 分子名称: | MERS-CoV Spike glycoprotein, antibody S41 heavy chain, antibody S41 light chain | 著者 | Zeng, J.W, Zhang, S.Y, Zhou, H.X, Wang, X.W. | 登録日 | 2022-02-25 | 公開日 | 2022-11-09 | 最終更新日 | 2022-11-23 | 実験手法 | ELECTRON MICROSCOPY (2.49 Å) | 主引用文献 | Cryoelectron microscopy structures of a human neutralizing antibody bound to MERS-CoV spike glycoprotein. Front Microbiol, 13, 2022
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