8G9Q

Tricomplex of Compound-1, KRAS G12C, and CypA

Summary for 8G9Q

• Entry DOI: 10.2210/pdb8g9q/pdb
• Descriptor: GTPase KRas, Peptidyl-prolyl cis-trans isomerase A, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (6 entities in total)
• Functional Keywords: inhibitor, complex, small gtpase, cancer, tricomplex, signaling protein-inhibitor complex, signaling protein/inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 38654.61

Authors

Tomlinson, A.C.A.,Chen, A.,Knox, J.E.,Yano, J.K. (deposition date: 2023-02-21, release date: 2023-08-16, Last modification date: 2023-08-30)

• Primary citation: Schulze, C.J.,Seamon, K.J.,Zhao, Y.,Yang, Y.C.,Cregg, J.,Kim, D.,Tomlinson, A.,Choy, T.J.,Wang, Z.,Sang, B.,Pourfarjam, Y.,Lucas, J.,Cuevas-Navarro, A.,Ayala-Santos, C.,Vides, A.,Li, C.,Marquez, A.,Zhong, M.,Vemulapalli, V.,Weller, C.,Gould, A.,Whalen, D.M.,Salvador, A.,Milin, A.,Saldajeno-Concar, M.,Dinglasan, N.,Chen, A.,Evans, J.,Knox, J.E.,Koltun, E.S.,Singh, M.,Nichols, R.,Wildes, D.,Gill, A.L.,Smith, J.A.M.,Lito, P.; Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS.; Science, 381:794-799, 2023; PubMed: 37590355; DOI: 10.1126/science.adg9652

Experimental method

X-RAY DIFFRACTION (1.4 Å)