7DZ1
Crystal structure of VIM-2 MBL in complex with 1-benzyl-5-methyl-1H-imidazole-2-carboxylic acid
Summary for 7DZ1
| Entry DOI | 10.2210/pdb7dz1/pdb |
| Descriptor | Beta-lactamase class B VIM-2, ZINC ION, 5-methyl-1-(phenylmethyl)imidazole-2-carboxylic acid, ... (4 entities in total) |
| Functional Keywords | metallo-beta-lactamase vim-2, vim-2, hydrolase |
| Biological source | Pseudomonas aeruginosa |
| Total number of polymer chains | 2 |
| Total formula weight | 50052.99 |
| Authors | Yan, Y.-H.,Li, G.-B. (deposition date: 2021-01-23, release date: 2022-01-26, Last modification date: 2023-11-29) |
| Primary citation | Yan, Y.H.,Li, W.,Chen, W.,Li, C.,Zhu, K.R.,Deng, J.,Dai, Q.Q.,Yang, L.L.,Wang, Z.,Li, G.B. Structure-guided optimization of 1H-imidazole-2-carboxylic acid derivatives affording potent VIM-Type metallo-beta-lactamase inhibitors. Eur.J.Med.Chem., 228:113965-113965, 2022 Cited by PubMed: 34763944DOI: 10.1016/j.ejmech.2021.113965 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.708 Å) |
Structure validation
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