7YHC
 
 | | Crystal structure of VIM-2 MBL in complex with 3-(4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl)phthalic acid | | 分子名称: | 3-[4-(3-aminophenyl)-1,2,3-triazol-1-yl]phthalic acid, Beta-lactamase class B VIM-2, ZINC ION | | 著者 | Li, G.-B, Yan, Y.-H. | | 登録日 | 2022-07-13 | | 公開日 | 2023-06-07 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.153 Å) | | 主引用文献 | Metal binding pharmacophore click-derived discovery of new broad-spectrum metallo-beta-lactamase inhibitors.
Eur.J.Med.Chem., 257, 2023
|
|
7V97
 | | Arsenic-bound p53 DNA-binding domain mutant V272M | | 分子名称: | ARSENIC, Cellular tumor antigen p53, ZINC ION | | 著者 | Lu, M, Xing, Y.F, Wang, Z.Y, Ni, Y, Song, H.X. | | 登録日 | 2021-08-24 | | 公開日 | 2022-08-31 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | Diverse rescue potencies of p53 mutations to ATO are predetermined by intrinsic mutational properties.
Sci Transl Med, 15, 2023
|
|
7NEK
 | | SusD protein from human gut uncultured Bacteroides | | 分子名称: | GLYCEROL, RagB SusD domain containing protein | | 著者 | Cioci, C, Tauzin, A, Wang, Z, Machado, B, Lippens, G, Potocki-Veronese, G. | | 登録日 | 2021-02-04 | | 公開日 | 2022-03-02 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | SusD protein from human gut uncultured Bacteroides
To Be Published
|
|
6IET
 | | The crystal structure of TRIM66 PHD-Bromo domain | | 分子名称: | Tripartite motif-containing protein 66, ZINC ION | | 著者 | Chen, J. | | 登録日 | 2018-09-17 | | 公開日 | 2019-09-18 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.101 Å) | | 主引用文献 | TRIM66 reads unmodified H3R2K4 and H3K56ac to respond to DNA damage in embryonic stem cells.
Nat Commun, 10, 2019
|
|
6JAU
 | | The complex structure of Pseudomonas aeruginosa MucA/MucB. | | 分子名称: | CALCIUM ION, GLYCEROL, HEXAETHYLENE GLYCOL, ... | | 著者 | Li, T, He, L.H, Li, C.C, Liu, L, Peng, C.T, Shen, Y.L, Qin, X.F, Xiao, Q.J, Zhu, Y.B, Song, Y.J, Zhao, N.l, Zhao, C, Yang, J, Mu, X.Y, Huang, Q, Bao, R. | | 登録日 | 2019-01-25 | | 公開日 | 2020-01-29 | | 最終更新日 | 2020-08-19 | | 実験手法 | X-RAY DIFFRACTION (1.905 Å) | | 主引用文献 | Molecular basis of the lipid-induced MucA-MucB dissociation in Pseudomonas aeruginosa.
Commun Biol, 3, 2020
|
|
6IEU
 | |
6JIJ
 | |
7BZ7
 | | Template lasso peptide C24 mutant F15Y | | 分子名称: | lasso peptide | | 著者 | Liu, X.H, Liu, T, Ma, X.J, Yu, J.H, Yang, D.H, Ma, M. | | 登録日 | 2020-04-27 | | 公開日 | 2021-04-28 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Rational generation of lasso peptides based on biosynthetic gene mutations and site-selective chemical modifications.
Chem Sci, 12, 2021
|
|
7F2E
 | |
7ETK
 | |
7ETL
 | | The crystal structure of FtmOx1-Y68F | | 分子名称: | 1,2-ETHANEDIOL, 2-OXOGLUTARIC ACID, CHLORIDE ION, ... | | 著者 | Zhou, J.H, Wu, L. | | 登録日 | 2021-05-13 | | 公開日 | 2021-12-01 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.992128 Å) | | 主引用文献 | Structural Insight into the Catalytic Mechanism of the Endoperoxide Synthase FtmOx1.
Angew.Chem.Int.Ed.Engl., 61, 2022
|
|
7ESD
 | | Mature Donggang virus | | 分子名称: | Genome polyprotein | | 著者 | Zhang, Y, Liang, D. | | 登録日 | 2021-05-10 | | 公開日 | 2022-05-18 | | 最終更新日 | 2022-06-29 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Replication is the key barrier during the dual-host adaptation of mosquito-borne flaviviruses.
Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
7CU6
 | | lasso peptide C24 mutant - A11V2C | | 分子名称: | lasso peptide C24_A11V2C | | 著者 | Ma, M, Liu, X.H. | | 登録日 | 2020-08-21 | | 公開日 | 2021-08-25 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Rational generation of lasso peptides based on biosynthetic gene mutations and site-selective chemical modifications.
Chem Sci, 12, 2021
|
|
7F2B
 | |
7F26
 | | Crystal structure of lysozyme | | 分子名称: | Lysozyme C | | 著者 | Liang, M. | | 登録日 | 2021-06-10 | | 公開日 | 2021-09-15 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Novel combined crystallization plate for high-throughput crystal screening and in situ data collection at a crystallography beamline.
Acta Crystallogr.,Sect.F, 77, 2021
|
|
7EQ2
 | | Crystal structure of GDP-bound Rab1a-T75D | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, COBALT HEXAMMINE(III), ... | | 著者 | Cao, Y.L, Gu, D.D, Gao, S. | | 登録日 | 2021-04-28 | | 公開日 | 2022-11-02 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.55090284 Å) | | 主引用文献 | Aurora kinase A-mediated phosphorylation triggers structural alteration of Rab1A to enhance ER complexity during mitosis
Nat.Struct.Mol.Biol., 2024
|
|
6UVQ
 | | Crystal structure of Apo AtmM | | 分子名称: | ACETATE ION, D-glucose O-methyltransferase, MAGNESIUM ION | | 著者 | Alvarado, S.K, Wang, Z, Miller, M.D, Thorson, J.S, Phillips Jr, G.N. | | 登録日 | 2019-11-04 | | 公開日 | 2020-11-25 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | | 主引用文献 | Structure of Apo AtmM
To Be Published
|
|
4E4K
 | | Crystal Structure of PPARgamma with the ligand JO21 | | 分子名称: | (2S)-3-phenyl-2-{[2'-(propan-2-yl)biphenyl-4-yl]oxy}propanoic acid, Peroxisome proliferator-activated receptor gamma | | 著者 | Pochetti, G, Montanari, R, Loiodice, F, Fracchiolla, G, Laghezza, A, Carbonara, G, Piemontese, L, Lavecchia, A, Novellino, E. | | 登録日 | 2012-03-13 | | 公開日 | 2013-01-23 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | New 2-(Aryloxy)-3-phenylpropanoic Acids as Peroxisome Proliferator-Activated Receptor alpha/gamma Dual Agonists Able To Upregulate Mitochondrial Carnitine Shuttle System Gene Expression.
J.Med.Chem., 56, 2013
|
|
4E4Q
 | | Crystal structure of PPARgamma with the ligand FS214 | | 分子名称: | (2R)-3-phenyl-2-{[2'-(propan-2-yl)biphenyl-4-yl]oxy}propanoic acid, Peroxisome proliferator-activated receptor gamma | | 著者 | Pochetti, G, Montanari, R, Loiodice, F, Fracchiolla, G, Laghezza, A, Carbonara, G, Piemontese, L, Lavecchia, A, Novellino, E. | | 登録日 | 2012-03-13 | | 公開日 | 2013-01-23 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | New 2-(Aryloxy)-3-phenylpropanoic Acids as Peroxisome Proliferator-Activated Receptor alpha/gamma Dual Agonists Able To Upregulate Mitochondrial Carnitine Shuttle System Gene Expression.
J.Med.Chem., 56, 2013
|
|
7DRT
 | | Human Wntless in complex with Wnt3a | | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Zhong, Q, Zhao, Y, Ye, F, Xiao, Z, Huang, G, Zhang, Y, Lu, P, Xu, W, Zhou, Q, Ma, D. | | 登録日 | 2020-12-29 | | 公開日 | 2021-07-14 | | 最終更新日 | 2021-09-08 | | 実験手法 | ELECTRON MICROSCOPY (2.2 Å) | | 主引用文献 | Cryo-EM structure of human Wntless in complex with Wnt3a.
Nat Commun, 12, 2021
|
|
8WD5
 | |
8VTB
 | | SthK R120A R124A in the presence of PIP2 and cAMP | | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Transcriptional regulator, ... | | 著者 | Schmidpeter, P.A.M, Thon, O, Nimigean, C.M. | | 登録日 | 2024-01-26 | | 公開日 | 2024-09-25 | | 最終更新日 | 2024-10-02 | | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | | 主引用文献 | PIP2 inhibits pore opening of the cyclic nucleotide-gated channel SthK.
Nat Commun, 15, 2024
|
|
8VTA
 | | SthK R120A in the presence of PIP2 and cAMP | | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Transcriptional regulator, ... | | 著者 | Schmidpeter, P.A.M, Thon, O, Nimigean, C.M. | | 登録日 | 2024-01-26 | | 公開日 | 2024-09-25 | | 最終更新日 | 2024-10-02 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | PIP2 inhibits pore opening of the cyclic nucleotide-gated channel SthK.
Nat Commun, 15, 2024
|
|
8VT9
 | | WT SthK in the presence of PIP2 and cAMP | | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Transcriptional regulator, ... | | 著者 | Schmidpeter, P.A.M, Thon, O, Nimigean, C.M. | | 登録日 | 2024-01-26 | | 公開日 | 2024-09-25 | | 最終更新日 | 2024-10-02 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | PIP2 inhibits pore opening of the cyclic nucleotide-gated channel SthK.
Nat Commun, 15, 2024
|
|
8XN7
 | | Crystal structure of HPK1 kinase domain T165E,S171E phosphomimetic mutant in complex with compound 9f | | 分子名称: | 5-amino-2-((6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino)-8-(2-(trifluoromethyl)benzyl)pyrido[2,3-d]pyrimidin-7(8H)-one, Mitogen-activated protein kinase kinase kinase kinase 1 | | 著者 | Huang, W.X, Liu, R, Ding, K. | | 登録日 | 2023-12-29 | | 公開日 | 2024-04-10 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Discovery of 5-aminopyrido[2,3-d]pyrimidin-7(8H)-one derivatives as new hematopoietic progenitor kinase 1 (HPK1) inhibitors.
Eur.J.Med.Chem., 269, 2024
|
|
