6IEU
 
 | |
4IT7
 | | Crystal structure of Al-CPI | | 分子名称: | CPI | | 著者 | Mei, G.Q, Liu, S.L, Sun, M.Z, Liu, J. | | 登録日 | 2013-01-17 | | 公開日 | 2014-01-29 | | 最終更新日 | 2014-06-11 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural Basis for the Immunomodulatory Function of Cysteine Protease Inhibitor from Human Roundworm Ascaris lumbricoides.
Plos One, 9, 2014
|
|
5H25
 | | EED in complex with PRC2 allosteric inhibitor compound 11 | | 分子名称: | 5-(2-fluorophenyl)-2,3-dihydroimidazo[2,1-a]isoquinoline, Histone-lysine N-methyltransferase EZH2, Polycomb protein EED | | 著者 | Zhao, K, Zhao, M, Luo, X, Zhang, H. | | 登録日 | 2016-10-14 | | 公開日 | 2017-01-25 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.88 Å) | | 主引用文献 | Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy
J. Med. Chem., 60, 2017
|
|
6IET
 | | The crystal structure of TRIM66 PHD-Bromo domain | | 分子名称: | Tripartite motif-containing protein 66, ZINC ION | | 著者 | Chen, J. | | 登録日 | 2018-09-17 | | 公開日 | 2019-09-18 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.101 Å) | | 主引用文献 | TRIM66 reads unmodified H3R2K4 and H3K56ac to respond to DNA damage in embryonic stem cells.
Nat Commun, 10, 2019
|
|
5H24
 | | EED in complex with PRC2 allosteric inhibitor compound 8 | | 分子名称: | 5-(furan-2-ylmethylamino)-[1,2,4]triazolo[4,3-a]pyridine-6-carbonitrile, Histone-lysine N-methyltransferase EZH2, Polycomb protein EED | | 著者 | Zhao, K, Zhao, M, Luo, X, Zhang, H. | | 登録日 | 2016-10-14 | | 公開日 | 2017-01-25 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy
J. Med. Chem., 60, 2017
|
|
8IVB
 | | K113-Ubiquitinated BAK | | 分子名称: | Bcl-2 homologous antagonist/killer, Ubiquitin | | 著者 | Dong, X, Cheng, P, Hou, Y.Z, Chen, Y.K, Liu, Z. | | 登録日 | 2023-03-26 | | 公開日 | 2024-01-31 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Parkin-mediated ubiquitination inhibits BAK apoptotic activity by blocking its canonical hydrophobic groove.
Commun Biol, 6, 2023
|
|
6WF4
 | | Crystal Structure of TerC Co-crystallized with Polyporic Acid | | 分子名称: | (2~5~S)-2~3~,2~5~,2~6~-trihydroxy[1~1~,2~1~:2~4~,3~1~-terphenyl]-2~2~(2~5~H)-one, ISOPROPYL ALCOHOL, Terfestatin Biosyntheis Enzyme C | | 著者 | Clinger, J.A, Miller, M.D, Hall, R.E, Zhang, Y, Elshahawi, S.I, Thorson, J.S, Van Lanen, S.G, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro) | | 登録日 | 2020-04-03 | | 公開日 | 2021-04-07 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | | 主引用文献 | Structural and functional characterization of two cooperative enzymes responsible for the stability
of p-terphenyls.
To be published
|
|
7V47
 | |
7V48
 | |
7V49
 | |
8C6I
 | | TMEM2 ectodomain | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | | 著者 | Hohenester, E. | | 登録日 | 2023-01-11 | | 公開日 | 2023-02-01 | | 最終更新日 | 2023-06-07 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Structure of the transmembrane protein 2 (TMEM2) ectodomain and its apparent lack of hyaluronidase activity.
Wellcome Open Res, 8, 2023
|
|
5GMZ
 | | Hepatitis B virus core protein Y132A mutant in complex with 4-methyl heteroaryldihydropyrimidine | | 分子名称: | (2S)-4,4-difluoro-1-[[(4S)-4-(4-fluorophenyl)-5-methoxycarbonyl-4-methyl-2-(1,3-thiazol-2-yl)-1H-pyrimidin-6-yl]methyl]pyrrolidine-2-carboxylic acid, CHLORIDE ION, Core protein, ... | | 著者 | Xu, Z.H, Zhou, Z. | | 登録日 | 2016-07-18 | | 公開日 | 2016-08-10 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Design and Synthesis of Orally Bioavailable 4-Methyl Heteroaryldihydropyrimidine Based Hepatitis B Virus (HBV) Capsid Inhibitors
J.Med.Chem., 59, 2016
|
|
1NFG
 | | Structure of D-hydantoinase | | 分子名称: | D-hydantoinase, ZINC ION | | 著者 | Xu, Z, Yang, Y, Jiang, W, Arnold, E, Ding, J. | | 登録日 | 2002-12-14 | | 公開日 | 2003-07-15 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Crystal Structure of D-Hydantoinase from Burkholderia pickettii at a Resolution of 2.7 Angstroms: Insights into the Molecular Basis of Enzyme Thermostability.
J.Bacteriol., 185, 2003
|
|
4ZP0
 | | Crystal structure of E. coli multidrug transporter MdfA in complex with deoxycholate | | 分子名称: | (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID, LAURYL DIMETHYLAMINE-N-OXIDE, Multidrug transporter MdfA | | 著者 | Zhang, X.C, Heng, J, Zhao, Y, Wang, X. | | 登録日 | 2015-05-07 | | 公開日 | 2015-08-19 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Substrate-bound structure of the E. coli multidrug resistance transporter MdfA
Cell Res., 25, 2015
|
|
4ZOW
 | | Crystal structure of E. coli multidrug transporter MdfA in complex with chloramphenicol | | 分子名称: | CHLORAMPHENICOL, Multidrug transporter MdfA | | 著者 | Zhang, X.C, Heng, J, Zhao, Y, Wang, X. | | 登録日 | 2015-05-07 | | 公開日 | 2015-08-19 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Substrate-bound structure of the E. coli multidrug resistance transporter MdfA
Cell Res., 25, 2015
|
|
7LH9
 | | Crystal structure of BRPF2 PWWP domain in complex with DNA | | 分子名称: | Bromodomain-containing protein 1, DNA | | 著者 | Zhang, M, Lei, M, Qin, S, Dong, A, Yang, A, Li, Y, Loppnau, P, Hughes, T.R, Arrowsmith, C.H, Edwards, A.M, Min, J, Liu, J, Structural Genomics Consortium (SGC) | | 登録日 | 2021-01-21 | | 公開日 | 2021-02-17 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Crystal structure of the BRPF2 PWWP domain in complex with DNA reveals a different binding mode than the HDGF family of PWWP domains.
Biochim Biophys Acta Gene Regul Mech, 1864, 2021
|
|
4ZP2
 | | Crystal structure of E. coli multidrug transporter MdfA in complex with n-dodecyl-N,N-dimethylamine-N-oxide | | 分子名称: | LAURYL DIMETHYLAMINE-N-OXIDE, Multidrug transporter MdfA | | 著者 | Zhang, X.C, Heng, J, Zhao, Y, Wang, X. | | 登録日 | 2015-05-07 | | 公開日 | 2015-08-19 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Substrate-bound structure of the E. coli multidrug resistance transporter MdfA
Cell Res., 25, 2015
|
|
8K0S
 | |
8K15
 | |
8K0R
 | |
8K0Q
 | |
8K0P
 | |
4LGI
 | | N-terminal truncated NleC structure | | 分子名称: | Uncharacterized protein | | 著者 | Li, W.Q, Liu, Y.X, Sheng, X.L, Yan, C.Y, Wang, J.W. | | 登録日 | 2013-06-28 | | 公開日 | 2014-01-15 | | 最終更新日 | 2015-02-25 | | 実験手法 | X-RAY DIFFRACTION (2.301 Å) | | 主引用文献 | Structure and mechanism of a type III secretion protease, NleC
Acta Crystallogr.,Sect.D, 70, 2014
|
|
5MF1
 | |
5M93
 | |
