7TY6
| Cryo-EM structure of human Anion Exchanger 1 bound to 4,4'-Diisothiocyanatodihydrostilbene-2,2'-Disulfonic Acid (H2DIDS) | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4,4'-Diisothiocyano-2,2'-stilbenedisulfonic acid, ... | 著者 | Capper, M.J, Mathiharan, Y.K, Yang, S, Stone, A.C, Wacker, D. | 登録日 | 2022-02-11 | 公開日 | 2023-08-16 | 最終更新日 | 2023-11-01 | 実験手法 | ELECTRON MICROSCOPY (2.98 Å) | 主引用文献 | Substrate binding and inhibition of the anion exchanger 1 transporter. Nat.Struct.Mol.Biol., 30, 2023
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6UCX
| S2 symmetric peptide design number 1, Wednesday | 分子名称: | S2-1, Wednesday, trifluoroacetic acid | 著者 | Mulligan, V.K, Kang, C.S, Antselovich, I, Sawaya, M.R, Yeates, T.O, Baker, D. | 登録日 | 2019-09-18 | 公開日 | 2020-09-23 | 最終更新日 | 2021-07-28 | 実験手法 | X-RAY DIFFRACTION (0.85 Å) | 主引用文献 | Computational design of mixed chirality peptide macrocycles with internal symmetry. Protein Sci., 29, 2020
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6UCY
| Multi-conformer model of Ketosteroid Isomerase from Pseudomonas Putida (pKSI) bound to 4-Androstenedione at 250 K | 分子名称: | 4-ANDROSTENE-3-17-DIONE, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Yabukarski, F, Herschlag, D, Biel, J.T, Fraser, J.S. | 登録日 | 2019-09-18 | 公開日 | 2020-09-23 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | 主引用文献 | Assessment of enzyme active site positioning and tests of catalytic mechanisms through X-ray-derived conformational ensembles. Proc.Natl.Acad.Sci.USA, 117, 2020
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7TY4
| Cryo-EM structure of human Anion Exchanger 1 | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Band 3 anion transport protein, ... | 著者 | Capper, M.J, Mathiharan, Y.K, Yang, S, Stone, A.C, Wacker, D. | 登録日 | 2022-02-11 | 公開日 | 2023-08-16 | 最終更新日 | 2023-11-01 | 実験手法 | ELECTRON MICROSCOPY (2.99 Å) | 主引用文献 | Substrate binding and inhibition of the anion exchanger 1 transporter. Nat.Struct.Mol.Biol., 30, 2023
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6UD9
| S2 symmetric peptide design number 2, Morticia | 分子名称: | S2-2, Morticia | 著者 | Mulligan, V.K, Kang, C.S, Antselovich, I, Sawaya, M.R, Yeates, T.O, Baker, D. | 登録日 | 2019-09-19 | 公開日 | 2020-09-23 | 最終更新日 | 2020-12-02 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Computational design of mixed chirality peptide macrocycles with internal symmetry. Protein Sci., 29, 2020
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6UDZ
| S2 symmetric peptide design number 4 crystal form 1, Pugsley | 分子名称: | S2-4, Pusgley crystal form 1, trifluoroacetic acid | 著者 | Mulligan, V.K, Kang, C.S, Antselovich, I, Sawaya, M.R, Yeates, T.O, Baker, D. | 登録日 | 2019-09-20 | 公開日 | 2020-09-23 | 最終更新日 | 2020-12-02 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Computational design of mixed chirality peptide macrocycles with internal symmetry. Protein Sci., 29, 2020
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6TT9
| rTBL Recombinant Lectin From Tepary Bean | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, HEXANE, ... | 著者 | Martinez Alarcon, D, Varrot, A. | 登録日 | 2019-12-26 | 公開日 | 2020-05-13 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Recombinant Lectin from Tepary Bean (Phaseolus acutifolius) with Specific Recognition for Cancer-Associated Glycans: Production, Structural Characterization, and Target Identification. Biomolecules, 10, 2020
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4CBV
| X-ray structure of full-length ComE from Streptococcus pneumoniae. | 分子名称: | COME | 著者 | Boudes, M, Durand, D, Graille, M, van Tilbeurgh, H, Quevillon-Cheruel, S. | 登録日 | 2013-10-16 | 公開日 | 2014-02-12 | 最終更新日 | 2014-05-14 | 実験手法 | X-RAY DIFFRACTION (3.39 Å) | 主引用文献 | Structural Insights Into the Dimerization of the Response Regulator Come from Streptococcus Pneumoniae. Nucleic Acids Res., 42, 2014
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7SXN
| Orb2A residues 1-9 MYNKFVNFI | 分子名称: | Orb2A residues 1-9 MYNKFVNFI | 著者 | Bowler, J.T, Sawaya, M.R, Boyer, D.R, Cascio, D, Eisenberg, D.S. | 登録日 | 2021-11-23 | 公開日 | 2022-10-05 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.05 Å) | 主引用文献 | Micro-electron diffraction structure of the aggregation-driving N terminus of Drosophila neuronal protein Orb2A reveals amyloid-like beta-sheets. J.Biol.Chem., 298, 2022
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1XHA
| Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants | 分子名称: | N-{4-[(4-{3-[(2R)-3,3-DIMETHYLPIPERIDIN-2-YL]-2-FLUORO-6-HYDROXYBENZOYL}BENZOYL)AMINO]AZEPAN-3-YL}ISONICOTINAMIDE, cAMP-dependent protein kinase inhibitor, alpha form, ... | 著者 | Breitenlechner, C.B, Friebe, W.-G, Brunet, E, Werner, G, Graul, K, Thomas, U, Kuenkele, K.-P, Schaefer, W, Gassel, M, Bossemeyer, D, Huber, R, Engh, R.A, Masjost, B. | 登録日 | 2004-09-17 | 公開日 | 2005-09-17 | 最終更新日 | 2024-06-26 | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | 主引用文献 | Design and crystal structures of protein kinase B-selective inhibitors in complex with protein kinase A and mutants J.Med.Chem., 48, 2005
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2ODA
| Crystal Structure of PSPTO_2114 | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Hypothetical protein PSPTO_2114, MAGNESIUM ION | 著者 | Peisach, E, Allen, K.N, Dunaway-Mariano, D, Wang, L, Burroughs, A.M, Aravind, L. | 登録日 | 2006-12-22 | 公開日 | 2007-09-04 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The X-ray crystallographic structure and activity analysis of a Pseudomonas-specific subfamily of the HAD enzyme superfamily evidences a novel biochemical function. Proteins, 70, 2007
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1XEV
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1XFQ
| structure of the blue shifted intermediate state of the photoactive yellow protein lacking the N-terminal part | 分子名称: | 4'-HYDROXYCINNAMIC ACID, Photoactive yellow protein | 著者 | Bernard, C, Houben, K, Derix, N.M, Marks, D, van der Horst, M.A, Hellingwerf, K.J, Boelens, R, Kaptein, R, van Nuland, N.A. | 登録日 | 2004-09-15 | 公開日 | 2005-08-16 | 最終更新日 | 2022-03-02 | 実験手法 | SOLUTION NMR | 主引用文献 | The solution structure of a transient photoreceptor intermediate: delta25 photoactive yellow protein STRUCTURE, 13, 2005
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6TPV
| Crystal structures of FNIII domain one and two of the human leucocyte common antigen-related protein, LAR | 分子名称: | IMIDAZOLE, Receptor-type tyrosine-protein phosphatase F | 著者 | Vilstrup, J.P, Thirup, S.S, Simonsen, A, Birkefeldt, T, Strandbygaard, D. | 登録日 | 2019-12-14 | 公開日 | 2020-05-13 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal and solution structures of fragments of the human leucocyte common antigen-related protein. Acta Crystallogr D Struct Biol, 76, 2020
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1XK8
| Divalent cation tolerant protein CUTA from Homo sapiens O60888 | 分子名称: | Divalent cation tolerant protein CUTA, SODIUM ION | 著者 | Tempel, W, Chen, L, Liu, Z.-J, Lee, D, Shah, A, Dailey, T.A, Mayer, M.R, Arendall III, W.B, Rose, J.P, Dailey, H.A, Richardson, J.S, Richardson, D.C, Wang, B.-C, Southeast Collaboratory for Structural Genomics (SECSG) | 登録日 | 2004-09-27 | 公開日 | 2004-10-19 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Divalent cation tolerant protein CUTA from Homo sapiens O60888 To be published
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1XGJ
| AmpC beta-lactamase in complex with 3-(4-carboxy-2-hydroxy-phenylsulfamoyl)-thiophene-2-carboxylic acid | 分子名称: | 3-{[(4-CARBOXY-2-HYDROXYANILINE]SULFONYL}THIOPHENE-2-CARBOXYLIC ACID, Beta-lactamase | 著者 | Tondi, D, Morandi, F, Bonnet, R, Costi, M.P, Shoichet, B.K. | 登録日 | 2004-09-17 | 公開日 | 2005-05-03 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Structure-based optimization of a non-beta-lactam lead results in inhibitors that do not up-regulate beta-lactamase expression in cell culture. J.Am.Chem.Soc., 127, 2005
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1XKM
| NMR structure of antimicrobial peptide distinctin in water | 分子名称: | Distinctin chain A, Distinctin chain B | 著者 | Amodeo, P, Raimondo, D, Andreotti, G, Motta, A, Scaloni, A. | 登録日 | 2004-09-29 | 公開日 | 2005-04-05 | 最終更新日 | 2022-03-02 | 実験手法 | SOLUTION NMR | 主引用文献 | A folding-dependent mechanism of antimicrobial peptide resistance to degradation unveiled by solution structure of distinctin. Proc.Natl.Acad.Sci.Usa, 102, 2005
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1XLX
| Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Cilomilast | 分子名称: | CILOMILAST, MAGNESIUM ION, ZINC ION, ... | 著者 | Card, G.L, England, B.P, Suzuki, Y, Fong, D, Powell, B, Lee, B, Luu, C, Tabrizizad, M, Gillette, S, Ibrahim, P.N, Artis, D.R, Bollag, G, Milburn, M.V, Kim, S.-H, Schlessinger, J, Zhang, K.Y.J. | 登録日 | 2004-09-30 | 公開日 | 2004-12-14 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | Structural Basis for the Activity of Drugs that Inhibit Phosphodiesterases. Structure, 12, 2004
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1XH8
| Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants | 分子名称: | N-[4-({4-[5-(4,4-DIMETHYLPIPERIDIN-1-YL)-2-HYDROXYBENZOYL]BENZOYL}AMINO)AZEPAN-3-YL]ISONICOTINAMIDE, cAMP-dependent protein kinase inhibitor, alpha form, ... | 著者 | Breitenlechner, C.B, Friebe, W.-G, Brunet, E, Werner, G, Graul, K, Thomas, U, Kuenkele, K.-P, Schaefer, W, Gassel, M, Bossemeyer, D, Huber, R, Engh, R.A, Masjost, B. | 登録日 | 2004-09-17 | 公開日 | 2005-09-17 | 最終更新日 | 2024-06-26 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Design and crystal structures of protein kinase B-selective inhibitors in complex with protein kinase A and mutants J.Med.Chem., 48, 2005
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7TDQ
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7TOR
| Mammalian 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein GR20 | 分子名称: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | 著者 | Loveland, A.B, Svidritskiy, E, Susorov, D, Lee, S, Park, A, Zvornicanin, S, Demo, G, Gao, F.B, Korostelev, A.A. | 登録日 | 2022-01-24 | 公開日 | 2022-05-25 | 最終更新日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM. Nat Commun, 13, 2022
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6W7L
| Structure of Tdp1 catalytic domain in complex with inhibitor XZ632p | 分子名称: | 1,2-ETHANEDIOL, 4-[(2-phenylimidazo[1,2-a]pyrazin-3-yl)amino]benzene-1,2-dicarboxylic acid, Tyrosyl-DNA phosphodiesterase 1 | 著者 | Lountos, G.T, Zhao, X.Z, Kiselev, E, Tropea, J.E, Needle, D, Pommier, Y, Burke, T.R, Waugh, D.S. | 登録日 | 2020-03-19 | 公開日 | 2021-03-24 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.856 Å) | 主引用文献 | Small molecule microarray identifies inhibitors of tyrosyl-DNA phosphodiesterase 1 that simultaneously access the catalytic pocket and two substrate binding sites Chemical Science, 12, 2021
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6W7K
| Structure of Tdp1 catalytic domain in complex with inhibitor XZ634p | 分子名称: | 1,2-ETHANEDIOL, 4-[(2-phenylimidazo[1,2-a]pyridin-3-yl)amino]benzene-1,2-dicarboxylic acid, Tyrosyl-DNA phosphodiesterase 1 | 著者 | Lountos, G.T, Zhao, X.Z, Kiselev, E, Tropea, J.E, Needle, D, Pommier, Y, Burke, T.R, Waugh, D.S. | 登録日 | 2020-03-19 | 公開日 | 2021-03-24 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Small molecule microarray identifies inhibitors of tyrosyl-DNA phosphodiesterase 1 that simultaneously access the catalytic pocket and two substrate binding sites Chemical Science, 12, 2021
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1XB3
| The D62C/K74C double mutant of Pseudomonas Aeruginosa Azurin | 分子名称: | Azurin, COPPER (II) ION | 著者 | Tigerstrom, A, Schwarz, F, Karlsson, G, Okvist, M, Alvarez-Rua, C, Maeder, D, Robb, F.T, Sjolin, L. | 登録日 | 2004-08-27 | 公開日 | 2004-10-19 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.501 Å) | 主引用文献 | Effects of a novel disulfide bond and engineered electrostatic interactions on the thermostability of azurin Biochemistry, 43, 2004
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7TOQ
| Mammalian 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein poly-PR | 分子名称: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | 著者 | Loveland, A.B, Svidritskiy, E, Susorov, D, Lee, S, Park, A, Zvornicanin, S, Demo, G, Gao, F.B, Korostelev, A.A. | 登録日 | 2022-01-24 | 公開日 | 2022-05-25 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM. Nat Commun, 13, 2022
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