6W7K

Structure of Tdp1 catalytic domain in complex with inhibitor XZ634p

Summary for 6W7K

• Entry DOI: 10.2210/pdb6w7k/pdb
• Descriptor: Tyrosyl-DNA phosphodiesterase 1, 4-[(2-phenylimidazo[1,2-a]pyridin-3-yl)amino]benzene-1,2-dicarboxylic acid, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: phosphodiesterase, inhibitor, cancer drug target, dna binding protein, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 105247.67

Authors

Lountos, G.T.,Zhao, X.Z.,Kiselev, E.,Tropea, J.E.,Needle, D.,Pommier, Y.,Burke, T.R.,Waugh, D.S. (deposition date: 2020-03-19, release date: 2021-03-24, Last modification date: 2023-10-18)

• Primary citation: Zhao, X.Z.,Kiselev, E.,Lountos, G.T.,Wang, W.,Tropea, J.E.,Needle, D.,Hilimire, T.A.,Schneekloth, J.S.,Waugh, D.S.,Pommier, Y.,Burke, T.R.; Small molecule microarray identifies inhibitors of tyrosyl-DNA phosphodiesterase 1 that simultaneously access the catalytic pocket and two substrate binding sites; Chemical Science, 12:3876-3884, 2021; DOI: 10.1039/D0SC05411A

Experimental method

X-RAY DIFFRACTION (1.7 Å)