1XGJ

AmpC beta-lactamase in complex with 3-(4-carboxy-2-hydroxy-phenylsulfamoyl)-thiophene-2-carboxylic acid

Summary for 1XGJ

• Entry DOI: 10.2210/pdb1xgj/pdb
• Related: 1KE4 1L2S 1XGI
• Descriptor: Beta-lactamase, 3-{[(4-CARBOXY-2-HYDROXYANILINE]SULFONYL}THIOPHENE-2-CARBOXYLIC ACID (3 entities in total)
• Functional Keywords: ampc, beta-lactamase, cephalosporinase, serine hydrolase, hydrolase
• Biological source: Escherichia coli
• Cellular location: Periplasm: P00811
• Total number of polymer chains: 2
• Total formula weight: 79862.51

Authors

Tondi, D.,Morandi, F.,Bonnet, R.,Costi, M.P.,Shoichet, B.K. (deposition date: 2004-09-17, release date: 2005-05-03, Last modification date: 2023-08-23)

• Primary citation: Tondi, D.,Morandi, F.,Bonnet, R.,Costi, M.P.,Shoichet, B.K.; Structure-based optimization of a non-beta-lactam lead results in inhibitors that do not up-regulate beta-lactamase expression in cell culture.; J.Am.Chem.Soc., 127:4632-4639, 2005; PubMed: 15796528; DOI: 10.1021/ja04

Experimental method

X-RAY DIFFRACTION (1.97 Å)