8E7F
| Crystal structure of the autotransporter Ssp from Serratia marcescens. | 分子名称: | CALCIUM ION, DI(HYDROXYETHYL)ETHER, Extracellular serine protease, ... | 著者 | Hor, L, Pilapitiya, A, Panjikar, S, Paxman, J.J, Heras, B. | 登録日 | 2022-08-23 | 公開日 | 2023-03-08 | 最終更新日 | 2023-03-15 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of a subtilisin-like autotransporter passenger domain reveals insights into its cytotoxic function. Nat Commun, 14, 2023
|
|
8DUF
| |
8DKZ
| |
5SXY
| |
8DKK
| |
8DMN
| |
8DK8
| |
8DKH
| |
8ECM
| |
8DKJ
| |
8DKL
| |
8E1P
| Crystal structure of BG505 SOSIP.v4.1-GT1.2 trimer in complex with gl-PGV20 and PGT124 Fabs | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505-SOSIP.v4.1-GT1.2gp120, ... | 著者 | Sarkar, A, Kumar, S, Wilson, I.A. | 登録日 | 2022-08-11 | 公開日 | 2023-06-21 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (3.82 Å) | 主引用文献 | Germline-targeting HIV-1 Env vaccination induces VRC01-class antibodies with rare insertions. Cell Rep Med, 4, 2023
|
|
8E6K
| 2H08 Fab in complex with influenza virus neuraminidase from A/Brevig Mission/1/1918 (H1N1) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2H08 fragment antigen binding heavy chain, 2H08 fragment antigen binding light chain, ... | 著者 | Turner, H.L, Ozorowski, G, Ward, A.B. | 登録日 | 2022-08-22 | 公開日 | 2023-08-09 | 最終更新日 | 2023-08-23 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Human anti-N1 monoclonal antibodies elicited by pandemic H1N1 virus infection broadly inhibit HxN1 viruses in vitro and in vivo. Immunity, 56, 2023
|
|
8E6J
| |
8DZZ
| Cryo-EM structure of chi dynein bound to Lis1 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Dynein heavy chain, ... | 著者 | Reimer, J.M, Lahiri, I, Leschziner, A.E. | 登録日 | 2022-08-08 | 公開日 | 2023-08-30 | 最終更新日 | 2023-09-27 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Lis1 relieves cytoplasmic dynein-1 autoinhibition by acting as a molecular wedge. Nat.Struct.Mol.Biol., 30, 2023
|
|
8E00
| Symmetry expansion of yeast cytoplasmic dynein-1 bound to Lis1 in the chi conformation. | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Dynein heavy chain, ... | 著者 | Reimer, J.M, Lahiri, I, Leschziner, A.E. | 登録日 | 2022-08-08 | 公開日 | 2023-08-30 | 最終更新日 | 2023-09-27 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Lis1 relieves cytoplasmic dynein-1 autoinhibition by acting as a molecular wedge. Nat.Struct.Mol.Biol., 30, 2023
|
|
8EEW
| CryoEM of the soluble OPA1 dimer from the GDP-AlFx bound helical assembly on a lipid membrane | 分子名称: | Dynamin-like 120 kDa protein, form S1, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Nyenhuis, S.B, Wu, X, Stanton, A.E, Strub, M.P, Yim, Y.I, Canagarajah, B, Hinshaw, J.E. | 登録日 | 2022-09-07 | 公開日 | 2023-06-28 | 最終更新日 | 2023-09-13 | 実験手法 | ELECTRON MICROSCOPY (5.48 Å) | 主引用文献 | OPA1 helical structures give perspective to mitochondrial dysfunction. Nature, 620, 2023
|
|
8EFF
| CryoEM of the soluble OPA1 tetramer from the GDP-AlFx bound helical assembly on a lipid membrane | 分子名称: | Dynamin-like 120 kDa protein, form S1, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Nyenhuis, S.B, Wu, X, Stanton, A.E, Strub, M.P, Yim, Y.I, Canagarajah, B, Hinshaw, J.E. | 登録日 | 2022-09-08 | 公開日 | 2023-06-28 | 最終更新日 | 2023-09-13 | 実験手法 | ELECTRON MICROSCOPY (5.48 Å) | 主引用文献 | OPA1 helical structures give perspective to mitochondrial dysfunction. Nature, 620, 2023
|
|
8EFS
| CryoEM of the soluble OPA1 tetramer from the apo helical assembly on a lipid membrane | 分子名称: | Dynamin-like 120 kDa protein, form S1 | 著者 | Nyenhuis, S.B, Wu, X, Stanton, A.E, Strub, M.P, Yim, Y.I, Canagarajah, B, Hinshaw, J.E. | 登録日 | 2022-09-09 | 公開日 | 2023-06-28 | 最終更新日 | 2023-09-13 | 実験手法 | ELECTRON MICROSCOPY (9.68 Å) | 主引用文献 | OPA1 helical structures give perspective to mitochondrial dysfunction. Nature, 620, 2023
|
|
8EF7
| CryoEM of the soluble OPA1 dimer from the apo helical assembly on a lipid membrane | 分子名称: | Dynamin-like 120 kDa protein, form S1 | 著者 | Nyenhuis, S.B, Wu, X, Stanton, A.E, Strub, M.P, Yim, Y.I, Canagarajah, B, Hinshaw, J.E. | 登録日 | 2022-09-08 | 公開日 | 2023-06-28 | 最終更新日 | 2023-09-13 | 実験手法 | ELECTRON MICROSCOPY (9.68 Å) | 主引用文献 | OPA1 helical structures give perspective to mitochondrial dysfunction. Nature, 620, 2023
|
|
8EFT
| CryoEM of the soluble OPA1 interfaces from the apo helical assembly on a lipid membrane | 分子名称: | Dynamin-like 120 kDa protein, form S1 | 著者 | Nyenhuis, S.B, Wu, X, Stanton, A.E, Strub, M.P, Yim, Y.I, Canagarajah, B, Hinshaw, J.E. | 登録日 | 2022-09-09 | 公開日 | 2023-06-28 | 最終更新日 | 2023-09-13 | 実験手法 | ELECTRON MICROSCOPY (9.68 Å) | 主引用文献 | OPA1 helical structures give perspective to mitochondrial dysfunction. Nature, 620, 2023
|
|
8ELC
| Human JNK2 bound to covalent inhibitor YL2056 | 分子名称: | 4-(dimethylamino)-N-{4-[(3S)-3-({4-[(8R)-2-phenylpyrazolo[1,5-a]pyridin-3-yl]pyrimidin-2-yl}amino)pyrrolidine-1-carbonyl]phenyl}butanamide, Mitogen-activated protein kinase 9 | 著者 | Li, L, Gurbani, D, Westover, K.D. | 登録日 | 2022-09-23 | 公開日 | 2023-06-28 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.072 Å) | 主引用文献 | Development of a Covalent Inhibitor of c-Jun N-Terminal Protein Kinase (JNK) 2/3 with Selectivity over JNK1. J.Med.Chem., 66, 2023
|
|
8EFR
| CryoEM of the soluble OPA1 interfaces with GDP-AlFx bound from the helical assembly on a lipid membrane | 分子名称: | Dynamin-like 120 kDa protein, form S1, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Nyenhuis, S.B, Wu, X, Stanton, A.E, Strub, M.P, Yim, Y.I, Canagarajah, B, Hinshaw, J.E. | 登録日 | 2022-09-09 | 公開日 | 2023-06-28 | 最終更新日 | 2023-09-13 | 実験手法 | ELECTRON MICROSCOPY (5.48 Å) | 主引用文献 | OPA1 helical structures give perspective to mitochondrial dysfunction. Nature, 620, 2023
|
|
8EM8
| Co-crystal structure of the cGMP-dependent protein kinase PKG from Plasmodium falciparum in complex with RY-1-165 | 分子名称: | UNKNOWN ATOM OR ION, [(3R)-3-{[(4M)-4-(4-cyclopropyl-2-phenyl-1H-imidazol-1-yl)pyrimidin-2-yl]amino}pyrrolidin-1-yl](1,3-thiazol-2-yl)methanone, cGMP-dependent protein kinase, ... | 著者 | Hutchinson, A, Dong, A, Seitova, A, Bhanot, P, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | 登録日 | 2022-09-27 | 公開日 | 2022-11-02 | 最終更新日 | 2024-08-07 | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | 主引用文献 | Structure-Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials. J.Med.Chem., 67, 2024
|
|
8ETR
| CryoEM Structure of NLRP3 NACHT domain in complex with G2394 | 分子名称: | (6S,8R)-N-[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl]-6-(methylamino)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-3-sulfonamide, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Murray, J.M, Johnson, M.C. | 登録日 | 2022-10-17 | 公開日 | 2022-11-02 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Overcoming Preclinical Safety Obstacles to Discover ( S )- N -((1,2,3,5,6,7-Hexahydro- s -indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5 H -pyrazolo[5,1- b ][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor. J.Med.Chem., 65, 2022
|
|