8EFR

CryoEM of the soluble OPA1 interfaces with GDP-AlFx bound from the helical assembly on a lipid membrane

This is a non-PDB format compatible entry.

Summary for 8EFR

• Entry DOI: 10.2210/pdb8efr/pdb
• EMDB information: 28063
• Descriptor: Dynamin-like 120 kDa protein, form S1, GUANOSINE-5'-DIPHOSPHATE, TETRAFLUOROALUMINATE ION, ... (5 entities in total)
• Functional Keywords: gtpase, dynamin-family protein, mitochondrial fusion protein, mitochondria, optic atrophy, lipid binding protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 18
• Total formula weight: 1617697.71

Authors

Nyenhuis, S.B.,Wu, X.,Stanton, A.E.,Strub, M.P.,Yim, Y.I.,Canagarajah, B.,Hinshaw, J.E. (deposition date: 2022-09-09, release date: 2023-06-28, Last modification date: 2023-09-13)

• Primary citation: Nyenhuis, S.B.,Wu, X.,Strub, M.P.,Yim, Y.I.,Stanton, A.E.,Baena, V.,Syed, Z.A.,Canagarajah, B.,Hammer, J.A.,Hinshaw, J.E.; OPA1 helical structures give perspective to mitochondrial dysfunction.; Nature, 620:1109-1116, 2023; PubMed: 37612506; DOI: 10.1038/s41586-023-06462-1

Experimental method

ELECTRON MICROSCOPY (5.48 Å)