8DKJ

Polymorphism in SARS-CoV-2 Nsp5 main protease reveals differences in cleavage of viral and host substrates

Summary for 8DKJ

Entry DOI	10.2210/pdb8dkj/pdb
Descriptor	3C-like proteinase nsp5 (2 entities in total)
Functional Keywords	viral protein, hydrolase-hydrolase inhibitor complex, hydrolase, hydrolase-inhibitor complex
Biological source	Severe acute respiratory syndrome coronavirus 2
Total number of polymer chains	1
Total formula weight	33853.56
Authors	Lu, J.,Khan, M.B.,Young, H.S.,Lemieux, M.J. (deposition date: 2022-07-05, release date: 2023-05-03, Last modification date: 2023-10-25)
Primary citation	Chen, S.A.,Arutyunova, E.,Lu, J.,Khan, M.B.,Rut, W.,Zmudzinski, M.,Shahbaz, S.,Iyyathurai, J.,Moussa, E.W.,Turner, Z.,Bai, B.,Lamer, T.,Nieman, J.A.,Vederas, J.C.,Julien, O.,Drag, M.,Elahi, S.,Young, H.S.,Lemieux, M.J. SARS-CoV-2 Mpro Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals Acs Cent.Sci., 9:696-708, 2023 Cited by DOI: 10.1021/acscentsci.3c00054 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.11 Å)

Structure validation