6X33
 
 | | Wt pig RyR1 in complex with apoCaM, EGTA condition (class 3, open) | | 分子名称: | Calmodulin-1, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine Receptor, ... | | 著者 | Woll, K.W, Haji-Ghassemi, O, Van Petegem, F. | | 登録日 | 2020-05-21 | | 公開日 | 2021-01-13 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM.
Nat Commun, 12, 2021
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6Y4P
 | | Calmodulin N53I variant bound to cardiac ryanodine receptor (RyR2) calmodulin binding domain | | 分子名称: | CALCIUM ION, Calmodulin-1, Ryanodine receptor 2 | | 著者 | Lau, K, Nielsen, L.H, Holt, C, Brohus, M, Sorensen, A.B, Larsen, K.T, Sommer, C, Van Petegem, F, Overgaard, M.T, Wimmer, R. | | 登録日 | 2020-02-21 | | 公開日 | 2020-04-29 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.13325572 Å) | | 主引用文献 | The arrhythmogenic N53I variant subtly changes the structure and dynamics in the calmodulin N-terminal domain, altering its interaction with the cardiac ryanodine receptor.
J.Biol.Chem., 295, 2020
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8SEU
 | | Cryo-EM Structure of RyR1 (Local Refinement of TMD) | | 分子名称: | Ryanodine receptor 1, ZINC ION | | 著者 | Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S. | | 登録日 | 2023-04-10 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-07-19 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives.
Structure, 31, 2023
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8SER
 | | Cryo-EM Structure of RyR1 + Adenosine | | 分子名称: | ADENOSINE, Glutathione S-transferase class-mu 26 kDa isozyme,Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 1, ... | | 著者 | Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S. | | 登録日 | 2023-04-10 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-07-19 | | 実験手法 | ELECTRON MICROSCOPY (3.42 Å) | | 主引用文献 | Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives.
Structure, 31, 2023
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8SEP
 | | Cryo-EM Structure of RyR1 + ADP | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Glutathione S-transferase class-mu 26 kDa isozyme,Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 1, ... | | 著者 | Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S. | | 登録日 | 2023-04-10 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-07-19 | | 実験手法 | ELECTRON MICROSCOPY (3.57 Å) | | 主引用文献 | Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives.
Structure, 31, 2023
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8SEV
 | | Cryo-EM Structure of RyR1 + ATP-gamma-S (Local Refinement of TMD) | | 分子名称: | PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Ryanodine receptor 1, ZINC ION | | 著者 | Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S. | | 登録日 | 2023-04-10 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-07-19 | | 実験手法 | ELECTRON MICROSCOPY (3.17 Å) | | 主引用文献 | Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives.
Structure, 31, 2023
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8SEQ
 | | Cryo-EM Structure of RyR1 + AMP | | 分子名称: | ADENOSINE MONOPHOSPHATE, Glutathione S-transferase class-mu 26 kDa isozyme,Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 1, ... | | 著者 | Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S. | | 登録日 | 2023-04-10 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-07-19 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives.
Structure, 31, 2023
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8SEY
 | | Cryo-EM Structure of RyR1 + Adenosine (Local Refinement of TMD) | | 分子名称: | ADENOSINE, Ryanodine receptor 1, ZINC ION | | 著者 | Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S. | | 登録日 | 2023-04-10 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-07-19 | | 実験手法 | ELECTRON MICROSCOPY (2.99 Å) | | 主引用文献 | Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives.
Structure, 31, 2023
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8SEW
 | | Cryo-EM Structure of RyR1 + ADP (Local Refinement of TMD) | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Ryanodine receptor 1, ZINC ION | | 著者 | Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S. | | 登録日 | 2023-04-10 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-07-19 | | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | | 主引用文献 | Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives.
Structure, 31, 2023
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8SF0
 | | Cryo-EM Structure of RyR1 + cAMP (Local Refinement of TMD) | | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Ryanodine receptor 1, ZINC ION | | 著者 | Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S. | | 登録日 | 2023-04-10 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-07-19 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives.
Structure, 31, 2023
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8SES
 | | Cryo-EM Structure of RyR1 + Adenine | | 分子名称: | ADENINE, Glutathione S-transferase class-mu 26 kDa isozyme,Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 1, ... | | 著者 | Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S. | | 登録日 | 2023-04-10 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-07-19 | | 実験手法 | ELECTRON MICROSCOPY (3.98 Å) | | 主引用文献 | Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives.
Structure, 31, 2023
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8SEO
 | | Cryo-EM Structure of RyR1 + ATP-gamma-S | | 分子名称: | Glutathione S-transferase class-mu 26 kDa isozyme,Peptidyl-prolyl cis-trans isomerase FKBP1B, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Ryanodine receptor 1, ... | | 著者 | Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S. | | 登録日 | 2023-04-10 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-07-19 | | 実験手法 | ELECTRON MICROSCOPY (3.92 Å) | | 主引用文献 | Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives.
Structure, 31, 2023
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8SET
 | | Cryo-EM Structure of RyR1 + cAMP | | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Glutathione S-transferase class-mu 26 kDa isozyme,Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 1, ... | | 著者 | Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S. | | 登録日 | 2023-04-10 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-07-19 | | 実験手法 | ELECTRON MICROSCOPY (3.42 Å) | | 主引用文献 | Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives.
Structure, 31, 2023
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8SEN
 | | Cryo-EM Structure of RyR1 | | 分子名称: | Glutathione S-transferase class-mu 26 kDa isozyme,Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 1, ZINC ION | | 著者 | Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S. | | 登録日 | 2023-04-10 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-07-19 | | 実験手法 | ELECTRON MICROSCOPY (3.49 Å) | | 主引用文献 | Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives.
Structure, 31, 2023
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8SEZ
 | | Cryo-EM Structure of RyR1 + Adenine (Local Refinement of TMD) | | 分子名称: | ADENINE, Ryanodine receptor 1, ZINC ION | | 著者 | Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S. | | 登録日 | 2023-04-10 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-07-19 | | 実験手法 | ELECTRON MICROSCOPY (3.54 Å) | | 主引用文献 | Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives.
Structure, 31, 2023
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8SEX
 | | Cryo-EM Structure of RyR1 + AMP (Local Refinement of TMD) | | 分子名称: | ADENOSINE MONOPHOSPHATE, Ryanodine receptor 1, ZINC ION | | 著者 | Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S. | | 登録日 | 2023-04-10 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-07-19 | | 実験手法 | ELECTRON MICROSCOPY (2.84 Å) | | 主引用文献 | Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives.
Structure, 31, 2023
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6PYA
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6PYF
 | | Sex Hormone-binding globulin mutant E176K in complex with Estradiol | | 分子名称: | CALCIUM ION, ESTRADIOL, Sex hormone-binding globulin | | 著者 | Round, P.W, Wu, T.S, Das, S, Van Petegem, F. | | 登録日 | 2019-07-29 | | 公開日 | 2019-12-25 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | | 主引用文献 | Molecular interactions between sex hormone-binding globulin and nonsteroidal ligands that enhance androgen activity.
J.Biol.Chem., 295, 2020
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6PYB
 | | Sex Hormone-binding globulin mutant E176K in complex with DVT | | 分子名称: | 4,4'-[(3R,4R)-oxolane-3,4-diylbis(methylene)]bis(2-methoxyphenol), CALCIUM ION, Sex hormone-binding globulin | | 著者 | Round, P.W, Das, S, Van Petegem, F. | | 登録日 | 2019-07-29 | | 公開日 | 2019-12-25 | | 最終更新日 | 2020-02-12 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Molecular interactions between sex hormone-binding globulin and nonsteroidal ligands that enhance androgen activity.
J.Biol.Chem., 295, 2020
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5C30
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5C33
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5DZG
 | | Crystal Structure of the catalytic nucleophile mutant of VvEG16 in complex with a xyloglucan tetradecasaccharide | | 分子名称: | VvEG16, endo-glucanase, alpha-D-xylopyranose-(1-6)-beta-D-glucopyranose-(1-4)-[alpha-D-xylopyranose-(1-6)]beta-D-glucopyranose-(1-4)-[alpha-D-xylopyranose-(1-6)]beta-D-glucopyranose-(1-4)-alpha-D-glucopyranose, ... | | 著者 | McGregor, N.G.S, Tung, C.C, Van Petegem, F, Brumer, H. | | 登録日 | 2015-09-25 | | 公開日 | 2016-09-21 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | | 主引用文献 | Crystallographic insight into the evolutionary origins of xyloglucan endotransglycosylases and endohydrolases.
Plant J., 89, 2017
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5DZE
 | | Crystal Structure of the catalytic nucleophile mutant of VvEG16 in complex with cellotetraose | | 分子名称: | beta-D-glucopyranose, beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-alpha-D-glucopyranose, endo-glucanase | | 著者 | McGregor, N.G.S, Tung, C.C, Van Petegem, F, Brumer, H. | | 登録日 | 2015-09-25 | | 公開日 | 2016-09-21 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (0.97 Å) | | 主引用文献 | Crystallographic insight into the evolutionary origins of xyloglucan endotransglycosylases and endohydrolases.
Plant J., 89, 2017
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5DZF
 | | Crystal Structure of the catalytic nucleophile mutant of VvEG16 in complex with a mixed-linkage glucan octasaccharide | | 分子名称: | SULFATE ION, beta-D-glucopyranose, beta-D-glucopyranose-(1-3)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-alpha-D-glucopyranose, ... | | 著者 | McGregor, N.G.S, Tung, C.C, Van Petegem, F, Brumer, H. | | 登録日 | 2015-09-25 | | 公開日 | 2016-09-21 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Crystallographic insight into the evolutionary origins of xyloglucan endotransglycosylases and endohydrolases.
Plant J., 89, 2017
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5KHI
 | | HCN2 CNBD in complex with purine riboside-3', 5'-cyclic monophosphate (cPuMP) | | 分子名称: | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2, Purine riboside-3',5'-cyclic monophosphate | | 著者 | Ng, L.C.T, Putrenko, I, Baronas, V, Van Petegem, F, Accili, E.A. | | 登録日 | 2016-06-14 | | 公開日 | 2016-09-14 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Cyclic Purine and Pyrimidine Nucleotides Bind to the HCN2 Ion Channel and Variably Promote C-Terminal Domain Interactions and Opening.
Structure, 24, 2016
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