6B4W
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6b4w by Molmil](/molmil-images/mine/6b4w) | TTK in Complex with Inhibitor | 分子名称: | 4-{[4-(cyclopentyloxy)-5-(2-methyl-1,3-benzoxazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}-3-methoxy-N-methylbenzamide, CACODYLATE ION, Dual specificity protein kinase TTK | 著者 | Delker, S, Chamberlain, P.P. | 登録日 | 2017-09-27 | 公開日 | 2017-10-25 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen. J. Med. Chem., 60, 2017
|
|
5EDS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5eds by Molmil](/molmil-images/mine/5eds) | Crystal structure of human PI3K-gamma in complex with benzimidazole inhibitor 5 | 分子名称: | 4-azanyl-6-[[(1~{S})-1-[6-fluoranyl-1-(3-methylsulfonylphenyl)benzimidazol-2-yl]ethyl]amino]pyrimidine-5-carbonitrile, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION | 著者 | Whittington, D.A, Tang, J, Yakowec, P. | 登録日 | 2015-10-21 | 公開日 | 2015-12-30 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Discovery, Optimization, and in Vivo Evaluation of Benzimidazole Derivatives AM-8508 and AM-9635 as Potent and Selective PI3K delta Inhibitors. J.Med.Chem., 59, 2016
|
|
6BN1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6bn1 by Molmil](/molmil-images/mine/6bn1) | Salvador Hippo SARAH domain complex | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, NICKEL (II) ION, Scaffold protein salvador, ... | 著者 | Cairns, L, Kavran, J.M. | 登録日 | 2017-11-15 | 公開日 | 2018-03-14 | 最終更新日 | 2018-04-25 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Salvador has an extended SARAH domain that mediates binding to Hippo kinase. J. Biol. Chem., 293, 2018
|
|
4UZD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4uzd by Molmil](/molmil-images/mine/4uzd) | SAR156497 an exquisitely selective inhibitor of Aurora kinases | 分子名称: | AURORA KINASE A, ethyl (9S)-9-[3-(1H-benzimidazol-2-yloxy)phenyl]-8-oxo-4,5,6,7,8,9-hexahydro-2H-pyrrolo[3,4-b]quinoline-3-carboxylate | 著者 | Pouzieux, S, Delarbre, L, Crenne, J.Y. | 登録日 | 2014-09-05 | 公開日 | 2014-11-19 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Sar156497 an Exquisitely Selective Inhibitor of Aurora Kinases. J.Med.Chem., 58, 2015
|
|
4UZH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4uzh by Molmil](/molmil-images/mine/4uzh) | SAR156497 an exquisitely selective inhibitor of Aurora kinases | 分子名称: | (4S)-4-(2-fluorophenyl)-2,4,6,7,8,9-hexahydro-5H-pyrazolo[3,4-b][1,7]naphthyridin-5-one, AURORA 2 KINASE DOMAIN | 著者 | Pouzieux, S, Maignan, S, Crenne, J.Y. | 登録日 | 2014-09-05 | 公開日 | 2014-11-19 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Sar156497 an Exquisitely Selective Inhibitor of Aurora Kinases. J.Med.Chem., 58, 2015
|
|
5HXB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5hxb by Molmil](/molmil-images/mine/5hxb) | Cereblon in complex with DDB1, CC-885, and GSPT1 | 分子名称: | 1-(3-chloro-4-methylphenyl)-3-({2-[(3S)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-5-yl}methyl)urea, DNA damage-binding protein 1, Eukaryotic peptide chain release factor GTP-binding subunit ERF3A, ... | 著者 | Chamberlain, P.P, Matyskiela, M, Pagarigan, B. | 登録日 | 2016-01-30 | 公開日 | 2016-06-29 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase. Nature, 535, 2016
|
|
5BTM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5btm by Molmil](/molmil-images/mine/5btm) | |
2B3P
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2b3p by Molmil](/molmil-images/mine/2b3p) | Crystal structure of a superfolder green fluorescent protein | 分子名称: | ACETIC ACID, CADMIUM ION, green fluorescent protein | 著者 | Pedelacq, J.D, Cabantous, S, Tran, T.H, Terwilliger, T.C, Waldo, G.S. | 登録日 | 2005-09-20 | 公開日 | 2005-11-08 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Engineering and characterization of a superfolder green fluorescent protein. Nat.Biotechnol., 24, 2006
|
|
2B3Q
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2b3q by Molmil](/molmil-images/mine/2b3q) | Crystal structure of a well-folded variant of green fluorescent protein | 分子名称: | MAGNESIUM ION, green fluorescent protein | 著者 | Pedelacq, J.D, Cabantous, S, Tran, T.H, Terwilliger, T.C, Waldo, G.S. | 登録日 | 2005-09-20 | 公開日 | 2005-11-08 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Engineering and characterization of a superfolder green fluorescent protein. Nat.Biotechnol., 24, 2006
|
|
3K48
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3k48 by Molmil](/molmil-images/mine/3k48) | Crystal structure of APRIL bound to a peptide | 分子名称: | Tumor necrosis factor ligand superfamily member 13, peptide | 著者 | Hymowitz, S.G. | 登録日 | 2009-10-05 | 公開日 | 2009-11-24 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Multiple novel classes of APRIL-specific receptor-blocking peptides isolated by phage display. J.Mol.Biol., 396, 2010
|
|
4K27
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4k27 by Molmil](/molmil-images/mine/4k27) | |
3S96
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3s96 by Molmil](/molmil-images/mine/3s96) | Crystal structure of 3B5H10 | 分子名称: | 3B5H10 FAB heavy chain, 3B5H10 FAB light chain | 著者 | Weisgraber, K, Peters-Libeu, C, Rutenber, E, Newhouse, Y, Finkbeiner, S. | 登録日 | 2011-05-31 | 公開日 | 2012-02-15 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Disease-associated polyglutamine stretches in monomeric huntingtin adopt a compact structure. J.Mol.Biol., 421, 2012
|
|
6O89
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6o89 by Molmil](/molmil-images/mine/6o89) | Anti-CD28xCD3 CODV Fab | 分子名称: | Anti-CD28xCD3 CODV-Fab Heavy chain, Anti-CD28xCD3 CODV-Fab Light chain | 著者 | Lord, D.M, Wei, R.R. | 登録日 | 2019-03-09 | 公開日 | 2019-11-20 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | Trispecific antibodies enhance the therapeutic efficacy of tumor-directed T cells through T cell receptor co-stimulation Nat Cancer, 1, 2020
|
|
6O8D
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6o8d by Molmil](/molmil-images/mine/6o8d) | Anti-CD28xCD3 CODV Fab bound to CD28 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Anti-CD28xCD3 CODV Fab Heavy chain, ... | 著者 | Lord, D.M, Wei, R.R. | 登録日 | 2019-03-09 | 公開日 | 2019-11-20 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.547 Å) | 主引用文献 | Trispecific antibodies enhance the therapeutic efficacy of tumor-directed T cells through T cell receptor co-stimulation To Be Published
|
|
8C1V
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8c1v by Molmil](/molmil-images/mine/8c1v) | SARS-CoV-2 S-trimer (3 RBDs up) bound to TriSb92, fitted into cryo-EM map | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Sb92, ... | 著者 | Huiskonen, J.T, Rissanen, I, Hannula, L. | 登録日 | 2022-12-21 | 公開日 | 2023-04-19 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Intranasal trimeric sherpabody inhibits SARS-CoV-2 including recent immunoevasive Omicron subvariants. Nat Commun, 14, 2023
|
|
4BWO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4bwo by Molmil](/molmil-images/mine/4bwo) | The FedF adhesin from entrrotoxigenic Escherichia coli is a sulfate- binding lectin | 分子名称: | BROMIDE ION, F18 FIMBRIAL ADHESIN AC, SULFATE ION | 著者 | Lonardi, E, Moonens, K, Buts, L, de Boer, A.R, Olsson, J.D.M, Weiss, M.S, Fabre, E, Guerardel, Y, Deelder, A.M, Oscarson, S, Wuhrer, M, Bouckaert, J. | 登録日 | 2013-07-03 | 公開日 | 2013-08-28 | 最終更新日 | 2014-05-28 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural Sampling of Glycan Interaction Profiles Reveals Mucosal Receptors for Fimbrial Adhesins of Enterotoxigenic Escherichia Coli Biology, 2, 2013
|
|
7QQB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7qqb by Molmil](/molmil-images/mine/7qqb) | Crystal structure of the envelope glycoprotein complex of Puumala virus in complex with the scFv fragment of the broadly neutralizing human antibody ADI-42898 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope polyprotein, GLYCEROL, ... | 著者 | Serris, A, Rey, F.A, Guardado-Calvo, P. | 登録日 | 2022-01-07 | 公開日 | 2023-06-21 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural and mechanistic basis of neutralization by a pan-hantavirus protective antibody. Sci Transl Med, 15, 2023
|
|
7A1X
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7a1x by Molmil](/molmil-images/mine/7a1x) | KRASG12C GDP form in complex with Cpd1 | 分子名称: | 3-(imidazol-1-ylmethyl)-1~{H}-indole, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Mathieu, M, Steier, V. | 登録日 | 2020-08-14 | 公開日 | 2021-10-13 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.32 Å) | 主引用文献 | KRAS G12C fragment screening renders new binding pockets. Small Gtpases, 13, 2022
|
|
7A1W
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7a1w by Molmil](/molmil-images/mine/7a1w) | KRASG12C GDP form in complex with Cpd3 | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, MAGNESIUM ION, ... | 著者 | Mathieu, M, Steier, V. | 登録日 | 2020-08-14 | 公開日 | 2021-10-13 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | KRAS G12C fragment screening renders new binding pockets. Small Gtpases, 13, 2022
|
|
7A1Y
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7a1y by Molmil](/molmil-images/mine/7a1y) | |
2JF1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2jf1 by Molmil](/molmil-images/mine/2jf1) | |
7ZL3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7zl3 by Molmil](/molmil-images/mine/7zl3) | |
4OYS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4oys by Molmil](/molmil-images/mine/4oys) | CRYSTAL STRUCTURE OF VPS34 IN COMPLEX WITH SAR405. | 分子名称: | (8S)-9-[(5-chloranylpyridin-3-yl)methyl]-2-[(3R)-3-methylmorpholin-4-yl]-8-(trifluoromethyl)-6,7,8,9a-tetrahydro-3H-pyrimido[1,2-a]pyrimidin-4-one, Phosphatidylinositol 3-kinase catalytic subunit type 3, SULFATE ION | 著者 | Mathieu, M, Marquette, J.p. | 登録日 | 2014-02-13 | 公開日 | 2014-10-22 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy. Nat.Chem.Biol., 10, 2014
|
|
2Z23
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2z23 by Molmil](/molmil-images/mine/2z23) | Crystal structure of Y.pestis oligo peptide binding protein OppA with tri-lysine ligand | 分子名称: | Periplasmic oligopeptide-binding protein, peptide (LYS)(LYS)(LYS) | 著者 | Tanabe, M, Bertland, T, Mirza, O, Byrne, B, Brown, K.A. | 登録日 | 2007-05-17 | 公開日 | 2007-10-30 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structures of OppA and PstS from Yersinia pestis indicate variability of interactions with transmembrane domains. Acta Crystallogr.,Sect.D, 63, 2007
|
|
2Z22
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2z22 by Molmil](/molmil-images/mine/2z22) | Crystal structure of phosphate preplasmic binding protein psts from yersinia pestis | 分子名称: | PHOSPHATE ION, Periplasmic phosphate-binding protein | 著者 | Tanabe, M, Byrne, B, Brown, K.A, Mirza, O, Bertland, T. | 登録日 | 2007-05-17 | 公開日 | 2007-10-30 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structures of OppA and PstS from Yersinia pestis indicate variability of interactions with transmembrane domains. Acta Crystallogr.,Sect.D, 63, 2007
|
|