7ZL3

Signal peptide mimicry primes Sec61 for client-selective inhibition

Summary for 7ZL3

Entry DOI	10.2210/pdb7zl3/pdb
EMDB information	14776 3068
Descriptor	Protein transport protein Sec61 subunit alpha, Protein transport protein Sec61 subunit gamma, Protein transport protein Sec61 subunit beta, ... (4 entities in total)
Functional Keywords	sec61 translocon, cryoem, membrane protein, protein biogenesis
Biological source	Ovis aries (sheep) More
Total number of polymer chains	4
Total formula weight	63374.41
Authors	Rehan, S.,Paavilainen O, V. (deposition date: 2022-04-13, release date: 2023-03-22, Last modification date: 2023-11-15)
Primary citation	Rehan, S.,Tranter, D.,Sharp, P.P.,Craven, G.B.,Lowe, E.,Anderl, J.L.,Muchamuel, T.,Abrishami, V.,Kuivanen, S.,Wenzell, N.A.,Jennings, A.,Kalyanaraman, C.,Strandin, T.,Javanainen, M.,Vapalahti, O.,Jacobson, M.P.,McMinn, D.,Kirk, C.J.,Huiskonen, J.T.,Taunton, J.,Paavilainen, V.O. Signal peptide mimicry primes Sec61 for client-selective inhibition. Nat.Chem.Biol., 19:1054-1062, 2023 Cited by PubMed: 37169961 DOI: 10.1038/s41589-023-01326-1 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.2 Å)

Structure validation