7ZL3
Signal peptide mimicry primes Sec61 for client-selective inhibition
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Protein transport protein Sec61 subunit alpha | polymer | 475 | 52034.1 | 1 | UniProt (A0A6P3YN15) Pfam (PF10559) Pfam (PF00344) | Ovis aries (sheep) | |
| 2 | B (B) | Protein transport protein Sec61 subunit gamma | polymer | 68 | 7752.3 | 1 | UniProt (W5PP18) Pfam (PF00584) | Ovis aries (sheep) | |
| 3 | C (C) | Protein transport protein Sec61 subunit beta | polymer | 29 | 2486.1 | 1 | Ovis aries (sheep) | ||
| 4 | D (E) | Cyclic depsipeptide signal peptide mimic | polymer | 6 | 1102.0 | 1 | synthetic construct |
Sequence modifications
A: 1 - 475 (UniProt: A0A6P3YN15)
B: 1 - 68 (UniProt: W5PP18)
| PDB | External Database | Details |
|---|---|---|
| - | Phe 62 | deletion |
| Ala 77 | Glu 78 | conflict |
| His 342 | Tyr 343 | conflict |
| Val 362 | Ala 363 | conflict |
| Ile 364 | Val 365 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Asp 29 | Val 29 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 63374.4 | |
| All* | Total formula weight | 63374.4 |
