4OYS

CRYSTAL STRUCTURE OF VPS34 IN COMPLEX WITH SAR405.

Summary for 4OYS

Entry DOI	10.2210/pdb4oys/pdb
Descriptor	Phosphatidylinositol 3-kinase catalytic subunit type 3, SULFATE ION, (8S)-9-[(5-chloranylpyridin-3-yl)methyl]-2-[(3R)-3-methylmorpholin-4-yl]-8-(trifluoromethyl)-6,7,8,9a-tetrahydro-3H-pyrimido[1,2-a]pyrimidin-4-one, ... (4 entities in total)
Functional Keywords	lipid kinase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	69427.51
Authors	Mathieu, M.,Marquette, J.p. (deposition date: 2014-02-13, release date: 2014-10-22, Last modification date: 2024-03-27)
Primary citation	Ronan, B.,Flamand, O.,Vescovi, L.,Dureuil, C.,Durand, L.,Fassy, F.,Bachelot, M.F.,Lamberton, A.,Mathieu, M.,Bertrand, T.,Marquette, J.P.,El-Ahmad, Y.,Filoche-Romme, B.,Schio, L.,Garcia-Echeverria, C.,Goulaouic, H.,Pasquier, B. A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy. Nat.Chem.Biol., 10:1013-1019, 2014 Cited by PubMed: 25326666 DOI: 10.1038/nchembio.1681 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation