4OYS

CRYSTAL STRUCTURE OF VPS34 IN COMPLEX WITH SAR405.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016301	molecular_function	kinase activity
A	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue SO4 A 901

Chain	Residue
A	ASN325
A	GLN326
A	GLU327
A	LYS328
A	LYS356

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site_id	AC2
Number of Residues	2
Details	binding site for residue SO4 A 902

Chain	Residue
A	ARG385
A	ARG482

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site_id	AC3
Number of Residues	2
Details	binding site for residue SO4 A 903

Chain	Residue
A	THR754
A	LYS756

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site_id	AC4
Number of Residues	3
Details	binding site for residue SO4 A 904

Chain	Residue
A	LEU393
A	TYR496
A	GLN649

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site_id	AC5
Number of Residues	9
Details	binding site for residue 1TT A 905

Chain	Residue
A	PHE612
A	PRO618
A	ILE634
A	GLN683
A	ILE685
A	SER687
A	ASP747
A	ASP761
A	HOH1008

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Functional Information from PROSITE/UniProt

site_id	PS00915
Number of Residues	15
Details	PI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. FKhg.DDLRQDqlilQ

Chain	Residue	Details
A	PHE635-GLN649

---

site_id	PS00916
Number of Residues	21
Details	PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ScAgycVitYILgVgDRHldN

Chain	Residue	Details
A	SER728-ASN748

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	266
Details	Domain: {"description":"PI3K/PI4K catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Region: {"description":"G-loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Region: {"description":"Catalytic loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	21
Details	Region: {"description":"Activation loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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