6B4W
TTK in Complex with Inhibitor
Summary for 6B4W
Entry DOI | 10.2210/pdb6b4w/pdb |
Descriptor | Dual specificity protein kinase TTK, 4-{[4-(cyclopentyloxy)-5-(2-methyl-1,3-benzoxazol-6-yl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}-3-methoxy-N-methylbenzamide, CACODYLATE ION (3 entities in total) |
Functional Keywords | protein kinase, signaling protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 35522.46 |
Authors | Delker, S.,Chamberlain, P.P. (deposition date: 2017-09-27, release date: 2017-10-25, Last modification date: 2024-03-13) |
Primary citation | Riggs, J.R.,Nagy, M.,Elsner, J.,Erdman, P.,Cashion, D.,Robinson, D.,Harris, R.,Huang, D.,Tehrani, L.,Deyanat-Yazdi, G.,Narla, R.K.,Peng, X.,Tran, T.,Barnes, L.,Miller, T.,Katz, J.,Tang, Y.,Chen, M.,Moghaddam, M.F.,Bahmanyar, S.,Pagarigan, B.,Delker, S.,LeBrun, L.,Chamberlain, P.P.,Calabrese, A.,Canan, S.S.,Leftheris, K.,Zhu, D.,Boylan, J.F. The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen. J. Med. Chem., 60:8989-9002, 2017 Cited by PubMed: 28991472DOI: 10.1021/acs.jmedchem.7b01223 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
Download full validation report