7QQB

Crystal structure of the envelope glycoprotein complex of Puumala virus in complex with the scFv fragment of the broadly neutralizing human antibody ADI-42898

This is a non-PDB format compatible entry.

Summary for 7QQB

• Entry DOI: 10.2210/pdb7qqb/pdb
• Descriptor: Envelope polyprotein, Single Chain Variable Fragment (scFv) of ADI-42898, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: hantavirus, neutralizing antibodies, fusion proteins, bunyavirus, viral protein
• Biological source: Puumala orthohantavirus; More
• Total number of polymer chains: 4
• Total formula weight: 256476.68

Authors

Serris, A.,Rey, F.A.,Guardado-Calvo, P. (deposition date: 2022-01-07, release date: 2023-06-21, Last modification date: 2024-02-07)

• Primary citation: Mittler, E.,Serris, A.,Esterman, E.S.,Florez, C.,Polanco, L.C.,O'Brien, C.M.,Slough, M.M.,Tynell, J.,Groning, R.,Sun, Y.,Abelson, D.M.,Wec, A.Z.,Haslwanter, D.,Keller, M.,Ye, C.,Bakken, R.R.,Jangra, R.K.,Dye, J.M.,Ahlm, C.,Rappazzo, C.G.,Ulrich, R.G.,Zeitlin, L.,Geoghegan, J.C.,Bradfute, S.B.,Sidoli, S.,Forsell, M.N.E.,Strandin, T.,Rey, F.A.,Herbert, A.S.,Walker, L.M.,Chandran, K.,Guardado-Calvo, P.; Structural and mechanistic basis of neutralization by a pan-hantavirus protective antibody.; Sci Transl Med, 15:eadg1855-eadg1855, 2023; PubMed: 37315110; DOI: 10.1126/scitranslmed.adg1855

Experimental method

X-RAY DIFFRACTION (2.6 Å)