7QQB
Crystal structure of the envelope glycoprotein complex of Puumala virus in complex with the scFv fragment of the broadly neutralizing human antibody ADI-42898
This is a non-PDB format compatible entry.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B (A, B) | Envelope polyprotein | polymer | 889 | 95672.6 | 2 | UniProt (A0A0B4U5I0) UniProt (A0A6M3W7M6) Pfam (PF01567) Pfam (PF01561) Pfam (PF20682) | Puumala orthohantavirus | M polyprotein |
2 | C, D (H, L) | Single Chain Variable Fragment (scFv) of ADI-42898 | polymer | 298 | 31558.8 | 2 | Homo sapiens | ||
3 | E (C) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G56014GC) | |||
4 | F, G (D, E) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
5 | H (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
6 | I, J, K, L (A, B, H, L) | water | water | 18.0 | 26 | Chemie (HOH) |
Sequence modifications
A, B: 20 - 381 (UniProt: A0A0B4U5I0)
A, B: 426 - 860 (UniProt: A0A6M3W7M6)
PDB | External Database | Details |
---|---|---|
Arg 18 | - | expression tag |
Ser 19 | - | expression tag |
Asp 362 | Glu 362 | conflict |
Gly 382 | - | linker |
Gly 383 | - | linker |
Ser 384 | - | linker |
Gly 385 | - | linker |
Leu 386 | - | linker |
Val 387 | - | linker |
Pro 388 | - | linker |
Arg 389 | - | linker |
Gly 390 | - | linker |
Ser 391 | - | linker |
Gly 392 | - | linker |
Gly 393 | - | linker |
Gly 394 | - | linker |
Ser 395 | - | linker |
Gly 396 | - | linker |
Gly 397 | - | linker |
Gly 398 | - | linker |
Ser 399 | - | linker |
Trp 400 | - | linker |
Ser 401 | - | linker |
His 402 | - | linker |
Pro 403 | - | linker |
Gln 404 | - | linker |
Phe 405 | - | linker |
Glu 406 | - | linker |
Lys 407 | - | linker |
Gly 408 | - | linker |
Gly 409 | - | linker |
Gly 410 | - | linker |
Thr 411 | - | linker |
Gly 412 | - | linker |
Gly 413 | - | linker |
Gly 414 | - | linker |
Thr 415 | - | linker |
Leu 416 | - | linker |
Val 417 | - | linker |
Pro 418 | - | linker |
Arg 419 | - | linker |
Gly 420 | - | linker |
Ser 421 | - | linker |
Gly 422 | - | linker |
Thr 423 | - | linker |
Gly 424 | - | linker |
Gly 425 | - | linker |
PDB | External Database | Details |
---|---|---|
Gly 861 | - | expression tag |
Leu 862 | - | expression tag |
Val 863 | - | expression tag |
Pro 864 | - | expression tag |
Arg 865 | - | expression tag |
Gly 866 | - | expression tag |
Ser 867 | - | expression tag |
Gly 868 | - | expression tag |
Pro 869 | - | expression tag |
Phe 870 | - | expression tag |
Glu 871 | - | expression tag |
Asp 872 | - | expression tag |
Asp 873 | - | expression tag |
Asp 874 | - | expression tag |
Asp 875 | - | expression tag |
Lys 876 | - | expression tag |
Ala 877 | - | expression tag |
Gly 878 | - | expression tag |
Trp 879 | - | expression tag |
Ser 880 | - | expression tag |
His 881 | - | expression tag |
Pro 882 | - | expression tag |
Gln 883 | - | expression tag |
Phe 884 | - | expression tag |
Glu 885 | - | expression tag |
Lys 886 | - | expression tag |
Gly 887 | - | expression tag |
Gly 888 | - | expression tag |
Gly 889 | - | expression tag |
Ser 890 | - | expression tag |
Gly 891 | - | expression tag |
Gly 892 | - | expression tag |
Gly 893 | - | expression tag |
Ser 894 | - | expression tag |
Gly 895 | - | expression tag |
Gly 896 | - | expression tag |
Gly 897 | - | expression tag |
Ser 898 | - | expression tag |
Trp 899 | - | expression tag |
Ser 900 | - | expression tag |
His 901 | - | expression tag |
Pro 902 | - | expression tag |
Gln 903 | - | expression tag |
Phe 904 | - | expression tag |
Glu 905 | - | expression tag |
Lys 906 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 254462.8 | |
Branched | Number of molecules | 3 |
Total formula weight | 1921.8 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 92.1 | |
All* | Total formula weight | 256476.7 |