6LVY
| Crystal structure of TLR7/Cpd-2 (SM-360320) complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 6-azanyl-2-(2-methoxyethoxy)-9-(phenylmethyl)-7H-purin-8-one, ... | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | 登録日 | 2020-02-06 | 公開日 | 2020-11-11 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural analysis reveals TLR7 dynamics underlying antagonism. Nat Commun, 11, 2020
|
|
6LW0
| Crystal structure of TLR7/Cpd-6 (DSR-139293) complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-ethoxy-8-(5-fluoranylpyridin-3-yl)-9-[[4-[[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]methyl]phenyl]methyl]purin-6-amine, ... | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | 登録日 | 2020-02-06 | 公開日 | 2020-11-11 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural analysis reveals TLR7 dynamics underlying antagonism. Nat Commun, 11, 2020
|
|
6LW1
| Cryo-EM structure of TLR7/Cpd-7 (DSR-139970) complex in open form | 分子名称: | 2-ethoxy-8-(5-fluoranylpyridin-3-yl)-6-methyl-9-[[4-[[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]methyl]phenyl]methyl]purine, Toll-like receptor 7 | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | 登録日 | 2020-02-06 | 公開日 | 2020-11-11 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural analysis reveals TLR7 dynamics underlying antagonism. Nat Commun, 11, 2020
|
|
6LVZ
| Crystal structure of TLR7/Cpd-3 (SM-394830) complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 6-azanyl-2-(2-methoxyethoxy)-9-(pyridin-3-ylmethyl)-7H-purin-8-one, ... | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | 登録日 | 2020-02-06 | 公開日 | 2020-11-11 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.83 Å) | 主引用文献 | Structural analysis reveals TLR7 dynamics underlying antagonism. Nat Commun, 11, 2020
|
|
6LVX
| Crystal structure of TLR7/Cpd-1 (SM-374527) complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 6-azanyl-2-butoxy-9-(phenylmethyl)-7H-purin-8-one, ... | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | 登録日 | 2020-02-06 | 公開日 | 2020-11-11 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.77 Å) | 主引用文献 | Structural analysis reveals TLR7 dynamics underlying antagonism. Nat Commun, 11, 2020
|
|
7WSI
| |
7WGE
| Human NLRP1 complexed with thioredoxin | 分子名称: | MAGNESIUM ION, NACHT, LRR and PYD domains-containing protein 1, ... | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | 登録日 | 2021-12-28 | 公開日 | 2023-07-05 | 最終更新日 | 2023-10-18 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural basis for thioredoxin-mediated suppression of NLRP1 inflammasome. Nature, 622, 2023
|
|
7WBU
| Cryo-EM structure of bovine NLRP9 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, NACHT, LRR and PYD domains-containing protein 9 | 著者 | Kamitsukasa, Y, Shimizu, T, Ohto, U. | 登録日 | 2021-12-17 | 公開日 | 2022-04-06 | 最終更新日 | 2022-04-27 | 実験手法 | ELECTRON MICROSCOPY (3.42 Å) | 主引用文献 | The structure of NLRP9 reveals a unique C-terminal region with putative regulatory function. Febs Lett., 596, 2022
|
|
7WBT
| Crystal structure of bovine NLRP9 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, NACHT, LRR and PYD domains-containing protein 9 | 著者 | Kamitsukasa, Y, Shimizu, T, Ohto, U. | 登録日 | 2021-12-17 | 公開日 | 2022-04-06 | 最終更新日 | 2022-04-27 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | The structure of NLRP9 reveals a unique C-terminal region with putative regulatory function. Febs Lett., 596, 2022
|
|
7WM4
| Cryo-EM structure of tetrameric TLR3 in complex with dsRNA (90 bp) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, RNA (81-MER), ... | 著者 | Sakaniwa, K, Ohto, U, Shimizu, T. | 登録日 | 2022-01-14 | 公開日 | 2023-01-25 | 最終更新日 | 2023-08-30 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transduction. Nat Commun, 14, 2023
|
|
7VGR
| |
7VGS
| |
3AK8
| Crystal structure of the SEp22 dodecamer, a Dps-like protein from Salmonella enterica subsp. enterica serovar Enteritidis | 分子名称: | DNA protection during starvation protein, MAGNESIUM ION, SULFATE ION | 著者 | Miyamoto, T, Asahina, Y, Miyazaki, S, Shimizu, H, Ohto, U, Noguchi, S, Satow, Y. | 登録日 | 2010-07-08 | 公開日 | 2011-01-12 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Structures of the SEp22 dodecamer, a Dps-like protein from Salmonella enterica subsp. enterica serovar Enteritidis Acta Crystallogr.,Sect.F, 67, 2011
|
|
7VAD
| |
7VAF
| |
7VAE
| Cryo-EM structure of bovine NTCP complexed with YN69202Fab | 分子名称: | Fab heavy chain from antibody IgG clone number YN69202, Fab light chain from antibody IgG clone number YN69202, Solute carrier family 10 (Sodium/bile acid cotransporter family), ... | 著者 | Asami, J, Shimizu, T, Ohto, U. | 登録日 | 2021-08-29 | 公開日 | 2022-05-25 | 最終更新日 | 2022-07-13 | 実験手法 | ELECTRON MICROSCOPY (3.55 Å) | 主引用文献 | Structure of the bile acid transporter and HBV receptor NTCP. Nature, 606, 2022
|
|
7VAG
| |
3AK9
| Crystal structure of the SEp22 dodecamer, a Dps-like protein from Salmonella enterica subsp. enterica serovar Enteritidis, FE-soaked form | 分子名称: | DNA protection during starvation protein, FE (II) ION, MAGNESIUM ION, ... | 著者 | Miyamoto, T, Asahina, Y, Miyazaki, S, Shimizu, H, Ohto, U, Noguchi, S, Satow, Y. | 登録日 | 2010-07-08 | 公開日 | 2011-01-12 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Structures of the SEp22 dodecamer, a Dps-like protein from Salmonella enterica subsp. enterica serovar Enteritidis Acta Crystallogr.,Sect.F, 67, 2011
|
|
7BPR
| Crystal structure of human TEX101 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, PLATINUM (II) ION, Testis-expressed protein 101 | 著者 | Masutani, M, Sakurai, S, Shimizu, T, Ohto, U. | 登録日 | 2020-03-23 | 公開日 | 2020-07-15 | 最終更新日 | 2020-12-23 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Crystal structure of TEX101, a glycoprotein essential for male fertility, reveals the presence of tandemly arranged Ly6/uPAR domains. Febs Lett., 594, 2020
|
|
7BPS
| Crystal structure of mouse TEX101 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, Testis-expressed protein 101, ... | 著者 | Masutani, M, Sakurai, S, Shimizu, T, Ohto, U. | 登録日 | 2020-03-23 | 公開日 | 2020-07-15 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Crystal structure of TEX101, a glycoprotein essential for male fertility, reveals the presence of tandemly arranged Ly6/uPAR domains. Febs Lett., 594, 2020
|
|
7BQI
| |
4R08
| Crystal structure of human TLR8 in complex with ssRNA40 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3'-O-[(R)-{[(2R,3aR,4R,6R,6aR)-6-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-hydroxy-2-oxidotetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-4-yl]methoxy}(hydroxy)phosphoryl]uridine 5'-(dihydrogen phosphate), ... | 著者 | Tanji, H, Ohto, U, Shimizu, T. | 登録日 | 2014-07-30 | 公開日 | 2015-01-14 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Toll-like receptor 8 senses degradation products of single-stranded RNA. Nat.Struct.Mol.Biol., 22, 2015
|
|
4R0A
| Crystal structure of human TLR8 in complex with uridine mononucleoside | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Toll-like receptor 8, ... | 著者 | Tanji, H, Ohto, U, Shimizu, T. | 登録日 | 2014-07-30 | 公開日 | 2015-01-14 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Toll-like receptor 8 senses degradation products of single-stranded RNA. Nat.Struct.Mol.Biol., 22, 2015
|
|
4R6A
| Crystal structure of human TLR8 in complex with Hybrid-2 | 分子名称: | 1-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, Toll-like receptor 8, ... | 著者 | Tanji, H, Ohto, U, Shimizu, T. | 登録日 | 2014-08-22 | 公開日 | 2015-08-26 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Hybrid-2: AnImidazoquinoline Dual Toll-like receptor 7/8 Agonist that Potently Activates Cytokine Production by Human Newborn and Adult Leukocytes To be Published
|
|
4R07
| Crystal structure of human TLR8 in complex with ORN06 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3'-O-[(R)-{[(2R,3aR,4R,6R,6aR)-6-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-hydroxy-2-oxidotetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-4-yl]methoxy}(hydroxy)phosphoryl]uridine 5'-(dihydrogen phosphate), ... | 著者 | Tanji, H, Ohto, U, Shibata, T, Taoka, M, Yamauchi, Y, Isobe, T, Miyake, K, Shimizu, T. | 登録日 | 2014-07-30 | 公開日 | 2015-01-14 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Toll-like receptor 8 senses degradation products of single-stranded RNA Nat.Struct.Mol.Biol., 22, 2015
|
|