9BF0
 
 | | MID domain of human Argo2 bound to UTP | | 分子名称: | Protein argonaute-2, URIDINE 5'-TRIPHOSPHATE | | 著者 | Harp, J.M, Egli, M. | | 登録日 | 2024-04-16 | | 公開日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | | 主引用文献 | Structure and Stability of Ago2 MID-Nucleotide Complexes: All-in-One (Drop) His 6 -SUMO Tag Removal, Nucleotide Binding, and Crystal Growth.
Curr Protoc, 4, 2024
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9BF2
 | | MID domain of Ago2 bound to UMP | | 分子名称: | Protein argonaute-2, URIDINE-5'-MONOPHOSPHATE | | 著者 | Harp, J.M, Egli, M. | | 登録日 | 2024-04-16 | | 公開日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | | 主引用文献 | Structure and Stability of Ago2 MID-Nucleotide Complexes: All-in-One (Drop) His 6 -SUMO Tag Removal, Nucleotide Binding, and Crystal Growth.
Curr Protoc, 4, 2024
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5DER
 | | RNA oligonucleotide containing (R)-C5'-ME-2'F U | | 分子名称: | RNA oligonucleotide containing (R)-C5'-Me-2'-FU | | 著者 | Harp, J.M, Egli, M. | | 登録日 | 2015-08-25 | | 公開日 | 2016-06-29 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5'-C-Methyl Pyrimidine-Modified Oligonucleotides.
J.Org.Chem., 81, 2016
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5DEK
 | | RNA octamer containing dT | | 分子名称: | COBALT HEXAMMINE(III), RNA oligonucleotide containing dT | | 著者 | Harp, J.M, Egli, M. | | 登録日 | 2015-08-25 | | 公開日 | 2016-07-20 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.993 Å) | | 主引用文献 | Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5'-C-Methyl Pyrimidine-Modified Oligonucleotides.
J.Org.Chem., 81, 2016
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5D8T
 | | RNA octamer containing (S)-5' methyl, 2'-F U. | | 分子名称: | COBALT HEXAMMINE(III), RNA oligonucleotide containing (S)-C5'-Me-2'-FU | | 著者 | Harp, J.M, Egli, M. | | 登録日 | 2015-08-17 | | 公開日 | 2016-06-29 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5'-C-Methyl Pyrimidine-Modified Oligonucleotides.
J.Org.Chem., 81, 2016
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6VEM
 | | Structure of RNA octamer | | 分子名称: | COBALT HEXAMMINE(III), Modified Octamer RNA | | 著者 | Pallan, P.S, Egli, M. | | 登録日 | 2020-01-02 | | 公開日 | 2020-11-18 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | | 主引用文献 | Synthesis, chirality-dependent conformational and biological properties of siRNAs containing 5'-(R)- and 5'-(S)-C-methyl-guanosine.
Nucleic Acids Res., 48, 2020
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8IBR
 | | Crystal structure of GH42 beta-galactosidase BiBga42A from Bifidobacterium longum subspecies infantis in complex with glycerol | | 分子名称: | Beta-galactosidase, DI(HYDROXYETHYL)ETHER, GLYCEROL | | 著者 | Hidaka, M, Fushinobu, S, Gotoh, A, Katayama, T. | | 登録日 | 2023-02-10 | | 公開日 | 2023-06-07 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Substrate recognition mode of a glycoside hydrolase family 42 beta-galactosidase from Bifidobacterium longum subspecies infantis ( Bi Bga42A) revealed by crystallographic and mutational analyses.
Microbiome Res Rep, 2, 2023
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8IBT
 | | Crystal structure of GH42 beta-galactosidase BiBga42A from Bifidobacterium longum subspecies infantis E318S mutant in complex with lacto-N-tetraose | | 分子名称: | Beta-galactosidase, beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-beta-D-galactopyranose-(1-4)-beta-D-glucopyranose | | 著者 | Hidaka, M, Fushinobu, S, Gotoh, A, Katayama, T. | | 登録日 | 2023-02-10 | | 公開日 | 2023-06-07 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Substrate recognition mode of a glycoside hydrolase family 42 beta-galactosidase from Bifidobacterium longum subspecies infantis ( Bi Bga42A) revealed by crystallographic and mutational analyses.
Microbiome Res Rep, 2, 2023
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8IBS
 | | Crystal structure of GH42 beta-galactosidase BiBga42A from Bifidobacterium longum subspecies infantis E160A/E318A mutant in complex with galactose | | 分子名称: | Beta-galactosidase, alpha-D-galactopyranose | | 著者 | Hidaka, M, Fushinobu, S, Gotoh, A, Katayama, T. | | 登録日 | 2023-02-10 | | 公開日 | 2023-06-07 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Substrate recognition mode of a glycoside hydrolase family 42 beta-galactosidase from Bifidobacterium longum subspecies infantis ( Bi Bga42A) revealed by crystallographic and mutational analyses.
Microbiome Res Rep, 2, 2023
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3NG5
 | | Crystal Structure of V30M transthyretin complexed with (-)-epigallocatechin gallate (EGCG) | | 分子名称: | (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate, GLYCEROL, Transthyretin | | 著者 | Miyata, M, Nakamura, T, Ikemizu, S, Chirifu, M, Yamagata, Y, Kai, H. | | 登録日 | 2010-06-11 | | 公開日 | 2010-07-07 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Crystal structure of green tea polyphenol(-)-epigallocatechin gallate (EGCG)-transthyretin complex reveals novel binding site distinct from thyroxine binding site
Biochemistry, 2010
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8CXR
 | | Crystal structure of MraY bound to a sphaerimicin analogue | | 分子名称: | (1S,4R,5S,6R,7S,9S,10S,11S,13S,14R)-9-[(2S,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxyoxolan-2-yl]-14-(hexadecanoyloxy)-5,6,13-trihydroxy-8,16-dioxa-2,11-diazatricyclo[9.3.1.1~4,7~]hexadecane-10-carboxylic acid, MraYAA nanobody, Phospho-N-acetylmuramoyl-pentapeptide-transferase | | 著者 | Mashalidis, E.H, Lee, S.Y. | | 登録日 | 2022-05-22 | | 公開日 | 2023-03-29 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (3.65 Å) | | 主引用文献 | Synthesis of macrocyclic nucleoside antibacterials and their interactions with MraY.
Nat Commun, 13, 2022
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5WZQ
 | | Alpha-N-acetylgalactosaminidase NagBb from Bifidobacterium bifidum - quadruple mutant | | 分子名称: | Alpha-N-acetylgalactosaminidase, GLYCEROL, ZINC ION | | 著者 | Sato, M, Arakawa, T, Ashida, H, Fushinobu, S. | | 登録日 | 2017-01-18 | | 公開日 | 2017-06-07 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The first crystal structure of a family 129 glycoside hydrolase from a probiotic bacterium reveals critical residues and metal cofactors
J. Biol. Chem., 292, 2017
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5WZR
 | | Alpha-N-acetylgalactosaminidase NagBb from Bifidobacterium bifidum - Gal-NHAc-DNJ complex | | 分子名称: | Alpha-N-acetylgalactosaminidase, CALCIUM ION, N-[(3S,4R,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)piperidin-3-yl]acetamide, ... | | 著者 | Sato, M, Arakawa, T, Ashida, H, Fushinobu, S. | | 登録日 | 2017-01-18 | | 公開日 | 2017-06-07 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.79 Å) | | 主引用文献 | The first crystal structure of a family 129 glycoside hydrolase from a probiotic bacterium reveals critical residues and metal cofactors
J. Biol. Chem., 292, 2017
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5WZN
 | | Alpha-N-acetylgalactosaminidase NagBb from Bifidobacterium bifidum - GalNAc complex | | 分子名称: | 2-acetamido-2-deoxy-alpha-D-galactopyranose, Alpha-N-acetylgalactosaminidase, CALCIUM ION, ... | | 著者 | Sato, M, Arakawa, T, Ashida, H, Fushinobu, S. | | 登録日 | 2017-01-18 | | 公開日 | 2017-06-07 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | The first crystal structure of a family 129 glycoside hydrolase from a probiotic bacterium reveals critical residues and metal cofactors
J. Biol. Chem., 292, 2017
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5WZP
 | | Alpha-N-acetylgalactosaminidase NagBb from Bifidobacterium bifidum - ligand free | | 分子名称: | Alpha-N-acetylgalactosaminidase, CALCIUM ION, ZINC ION | | 著者 | Sato, M, Arakawa, T, Ashida, H, Fushinobu, S. | | 登録日 | 2017-01-18 | | 公開日 | 2017-06-07 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.64 Å) | | 主引用文献 | The first crystal structure of a family 129 glycoside hydrolase from a probiotic bacterium reveals critical residues and metal cofactors
J. Biol. Chem., 292, 2017
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5GQG
 | | Crystal structure of lacto-N-biosidase LnbX from Bifidobacterium longum subsp. longum, galacto-N-biose complex | | 分子名称: | CALCIUM ION, Lacto-N-biosidase, beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose | | 著者 | Yamada, C, Arakawa, T, Katayama, T, Fushinobu, S. | | 登録日 | 2016-08-07 | | 公開日 | 2017-04-19 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Molecular Insight into Evolution of Symbiosis between Breast-Fed Infants and a Member of the Human Gut Microbiome Bifidobacterium longum
Cell Chem Biol, 24, 2017
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5GQF
 | | Crystal structure of lacto-N-biosidase LnbX from Bifidobacterium longum subsp. longum, lacto-N-biose complex | | 分子名称: | CALCIUM ION, Lacto-N-biosidase, beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Yamada, C, Arakawa, T, Katayama, T, Fushinobu, S. | | 登録日 | 2016-08-07 | | 公開日 | 2017-04-19 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | | 主引用文献 | Molecular Insight into Evolution of Symbiosis between Breast-Fed Infants and a Member of the Human Gut Microbiome Bifidobacterium longum
Cell Chem Biol, 24, 2017
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5V1L
 | | Structure of S-GNA dodecamer | | 分子名称: | RNA (5'-R(*CP*GP*CP*GP*AP*AP*UP*(ZTH)P*AP*GP*CP*G)-3'), SPERMINE, STRONTIUM ION | | 著者 | Pallan, P.S, Egli, M. | | 登録日 | 2017-03-02 | | 公開日 | 2017-06-14 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA.
J. Am. Chem. Soc., 139, 2017
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7LO9
 | | RNA dodecamer containing a GNA A residue | | 分子名称: | Chains: A,B,C,D | | 著者 | Harp, J.M, Wawrzak, Z, Egli, M. | | 登録日 | 2021-02-09 | | 公開日 | 2021-12-22 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | | 主引用文献 | Overcoming GNA/RNA base-pairing limitations using isonucleotides improves the pharmacodynamic activity of ESC+ GalNAc-siRNAs.
Nucleic Acids Res., 49, 2021
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5V1K
 | | Structure of R-GNA dodecamer | | 分子名称: | RNA (5'-R(*CP*GP*CP*GP*AP*AP*(5BU)P*(8RJ)P*AP*GP*CP*G)-3') | | 著者 | Pallan, P.S, Egli, M. | | 登録日 | 2017-03-02 | | 公開日 | 2017-06-21 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (1.18 Å) | | 主引用文献 | Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA.
J. Am. Chem. Soc., 2017
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5V2H
 | | RNA octamer containing glycol nucleic acid, SgnT | | 分子名称: | COBALT HEXAMMINE(III), MAGNESIUM ION, RNA (5'-R(*(CBV)P*GP*AP*AP*(ZTH)P*UP*CP*G)-3') | | 著者 | Harp, J.M, Egli, M. | | 登録日 | 2017-03-04 | | 公開日 | 2017-06-14 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (1.080013 Å) | | 主引用文献 | Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA.
J. Am. Chem. Soc., 139, 2017
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5GQC
 | | Crystal structure of lacto-N-biosidase LnbX from Bifidobacterium longum subsp. longum, ligand-free form | | 分子名称: | CALCIUM ION, Lacto-N-biosidase, SODIUM ION | | 著者 | Yamada, C, Arakawa, T, Katayama, T, Fushinobu, S. | | 登録日 | 2016-08-07 | | 公開日 | 2017-04-19 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.36 Å) | | 主引用文献 | Molecular Insight into Evolution of Symbiosis between Breast-Fed Infants and a Member of the Human Gut Microbiome Bifidobacterium longum
Cell Chem Biol, 24, 2017
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2ZNU
 | | Crystal structure of the ligand-binding core of the human ionotropic glutamate receptor, GluR5, in complex with a novel selective agonist, neodysiherbaine A | | 分子名称: | (2R,3aR,6R,7R,7aR)-2-[(2S)-2-amino-2-carboxyethyl]-6,7-dihydroxyhexahydro-2H-furo[3,2-b]pyran-2-carboxylic acid, BETA-MERCAPTOETHANOL, Glutamate receptor, ... | | 著者 | Unno, M, Sasaki, M, Ikeda-Saito, M. | | 登録日 | 2008-05-01 | | 公開日 | 2009-05-05 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Binding and Selectivity of the Marine Toxin Neodysiherbaine A and Its Synthetic Analogues to GluK1 and GluK2 Kainate Receptors.
J.Mol.Biol., 413, 2011
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2ZNT
 | | Crystal structure of the ligand-binding core of the human ionotropic glutamate receptor, GluR5, in complex with a novel selective agonist, dysiherbaine | | 分子名称: | (2R,3aR,6S,7R,7aR)-2-[(2S)-2-amino-2-carboxyethyl]-6-hydroxy-7-(methylamino)hexahydro-2H-furo[3,2-b]pyran-2-carboxylic acid, BETA-MERCAPTOETHANOL, Glutamate receptor, ... | | 著者 | Unno, M, Sasaki, M, Ikeda-Saito, M. | | 登録日 | 2008-05-01 | | 公開日 | 2009-05-05 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Binding and Selectivity of the Marine Toxin Neodysiherbaine A and Its Synthetic Analogues to GluK1 and GluK2 Kainate Receptors.
J.Mol.Biol., 413, 2011
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2ZNS
 | | Crystal structure of the ligand-binding core of the human ionotropic glutamate receptor, GluR5, in complex with glutamate | | 分子名称: | GLUTAMIC ACID, Glutamate receptor, ionotropic kainate 1 | | 著者 | Unno, M, Sasaki, M, Ikeda-Saito, M. | | 登録日 | 2008-05-01 | | 公開日 | 2009-05-05 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Binding and Selectivity of the Marine Toxin Neodysiherbaine A and Its Synthetic Analogues to GluK1 and GluK2 Kainate Receptors.
J.Mol.Biol., 413, 2011
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