7LO9

RNA dodecamer containing a GNA A residue

Summary for 7LO9

Entry DOI	10.2210/pdb7lo9/pdb
Descriptor	Chains: A,B,C,D (2 entities in total)
Functional Keywords	rna crystal structure, glycol nucleic acid, rna
Biological source	synthetic construct
Total number of polymer chains	4
Total formula weight	15488.88
Authors	Harp, J.M.,Wawrzak, Z.,Egli, M. (deposition date: 2021-02-09, release date: 2021-12-22, Last modification date: 2024-05-22)
Primary citation	Schlegel, M.K.,Matsuda, S.,Brown, C.R.,Harp, J.M.,Barry, J.D.,Berman, D.,Castoreno, A.,Schofield, S.,Szeto, J.,Manoharan, M.,Charisse, K.,Egli, M.,Maier, M.A. Overcoming GNA/RNA base-pairing limitations using isonucleotides improves the pharmacodynamic activity of ESC+ GalNAc-siRNAs. Nucleic Acids Res., 49:10851-10867, 2021 Cited by PubMed: 34648028 DOI: 10.1093/nar/gkab916 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.78 Å)

Structure validation