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7LO9
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BU of 7lo9 by Molmil
RNA dodecamer containing a GNA A residue
分子名称: Chains: A,B,C,D
著者Harp, J.M, Wawrzak, Z, Egli, M.
登録日2021-02-09
公開日2021-12-22
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献Overcoming GNA/RNA base-pairing limitations using isonucleotides improves the pharmacodynamic activity of ESC+ GalNAc-siRNAs.
Nucleic Acids Res., 49, 2021
6VEM
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BU of 6vem by Molmil
Structure of RNA octamer
分子名称: COBALT HEXAMMINE(III), Modified Octamer RNA
著者Pallan, P.S, Egli, M.
登録日2020-01-02
公開日2020-11-18
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献Synthesis, chirality-dependent conformational and biological properties of siRNAs containing 5'-(R)- and 5'-(S)-C-methyl-guanosine.
Nucleic Acids Res., 48, 2020
8THQ
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BU of 8thq by Molmil
Nonamer RNA bound to hAgo2-PAZ
分子名称: Protein argonaute-2, RNA (5'-R(*CP*GP*UP*GP*AP*CP*UP*CP*U)-3')
著者Pallan, P.S, Harp, J.M, Egli, M.
登録日2023-07-17
公開日2024-10-16
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献Single-Stranded Hairpin Loop RNAs (loopmeRNAs) Potently Induce Gene Silencing through the RNA Interference Pathway.
J.Am.Chem.Soc., 2024
6CY2
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BU of 6cy2 by Molmil
RNA octamer containing 2'-OMe, 4'Calpha-OMe U.
分子名称: RNA (5'-R(*(CBV)P*GP*AP*AP*(UOA)P*UP*CP*G)-3')
著者Harp, J.M, Egli, M.
登録日2018-04-04
公開日2018-08-29
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.
Nucleic Acids Res., 46, 2018
6CXZ
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BU of 6cxz by Molmil
RNA octamer containing 2'-F, 4'-Calpha-Me U.
分子名称: CACODYLATE ION, COBALT HEXAMMINE(III), RNA (5'-R(*CP*GP*AP*AP*(U4M)P*UP*CP*G)-3')
著者Harp, J.M, Egli, M.
登録日2018-04-04
公開日2018-08-29
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.
Nucleic Acids Res., 46, 2018
6CY4
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BU of 6cy4 by Molmil
RNA octamer containing 2'-OMe, 4'- Cbeta-OMe U.
分子名称: RNA (5'-R(*(CBV)P*GP*AP*AP*(UOB)P*UP*CP*G)-3')
著者Harp, J.M, Egli, M.
登録日2018-04-04
公開日2018-08-29
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.851 Å)
主引用文献Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.
Nucleic Acids Res., 46, 2018
5V1L
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BU of 5v1l by Molmil
Structure of S-GNA dodecamer
分子名称: RNA (5'-R(*CP*GP*CP*GP*AP*AP*UP*(ZTH)P*AP*GP*CP*G)-3'), SPERMINE, STRONTIUM ION
著者Pallan, P.S, Egli, M.
登録日2017-03-02
公開日2017-06-14
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA.
J. Am. Chem. Soc., 139, 2017
5V1K
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BU of 5v1k by Molmil
Structure of R-GNA dodecamer
分子名称: RNA (5'-R(*CP*GP*CP*GP*AP*AP*(5BU)P*(8RJ)P*AP*GP*CP*G)-3')
著者Pallan, P.S, Egli, M.
登録日2017-03-02
公開日2017-06-21
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.18 Å)
主引用文献Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA.
J. Am. Chem. Soc., 2017
6CY0
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BU of 6cy0 by Molmil
RNA octamer containing 2'-F, 4'-Cbeta-OMe U.
分子名称: RNA (5'-R(*(CBV)P*GP*AP*AP*(UFB)P*UP*CP*G)-3')
著者Harp, J.M, Egli, M.
登録日2018-04-04
公開日2018-08-29
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.398 Å)
主引用文献Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.
Nucleic Acids Res., 46, 2018
5V2H
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BU of 5v2h by Molmil
RNA octamer containing glycol nucleic acid, SgnT
分子名称: COBALT HEXAMMINE(III), MAGNESIUM ION, RNA (5'-R(*(CBV)P*GP*AP*AP*(ZTH)P*UP*CP*G)-3')
著者Harp, J.M, Egli, M.
登録日2017-03-04
公開日2017-06-14
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.080013 Å)
主引用文献Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA.
J. Am. Chem. Soc., 139, 2017
2Q1R
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BU of 2q1r by Molmil
Crystal Structure Analysis of the RNA Dodecamer CGCGAAUUAGCG, with a G-A mismatch.
分子名称: MAGNESIUM ION, RNA (5'-R(*CP*GP*CP*GP*AP*AP*UP*UP*AP*GP*CP*G)-3')
著者Li, F, Pallan, P.S.
登録日2007-05-25
公開日2007-10-30
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.12 Å)
主引用文献Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme.
Nucleic Acids Res., 35, 2007
2Q1O
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BU of 2q1o by Molmil
Crystal Structure Analysis of the RNA Dodecamer CGC-NF2-AAUUGGCG, with an Incorporated 2,4-Difluorotoluyl Residue (NF2)
分子名称: RNA (5'-R(*CP*GP*CP*(NF2)P*AP*AP*UP*UP*GP*GP*CP*G)-3')
著者Li, F, Pallan, P.S.
登録日2007-05-25
公開日2007-10-30
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme.
Nucleic Acids Res., 35, 2007
468D
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BU of 468d by Molmil
CRYSTAL STRUCTURE AND IMPROVED ANTISENSE PROPERTIES OF 2'-O-(2-METHOXYETHYL)-RNA
分子名称: MAGNESIUM ION, RNA (5'-R(*(C43)P*(G48)P*(C43)P*(G48)P*(A44)P*(A44)P*(U36)P*(U36)P*(C43)P*(G48)P*(C43)P*(G48))-3')
著者Teplova, M, Minasov, G, Tereshko, V, Inamati, G, Cook, P.D, Egli, M.
登録日1999-04-29
公開日1999-05-12
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure and improved antisense properties of 2'-O-(2-methoxyethyl)-RNA.
Nat.Struct.Biol., 6, 1999
470D
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BU of 470d by Molmil
CRYSTAL STRUCTURE AND IMPROVED ANTISENSE PROPERTIES OF 2'-O-(2-METHOXYETHYL)-RNA
分子名称: MAGNESIUM ION, RNA (5'-R(*(C43)P*(G48)P*(C43)P*(G48)P*(A44)P*(A44)P*(U36)P*(U36)P*(C43)P*(G48)P*(C43)P*(G48))-3')
著者Teplova, M, Minasov, G, Tereshko, V, Inamati, G, Cook, P.D, Egli, M.
登録日1999-04-29
公開日1999-05-12
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Crystal structure and improved antisense properties of 2'-O-(2-methoxyethyl)-RNA.
Nat.Struct.Biol., 6, 1999
471D
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BU of 471d by Molmil
CRYSTAL STRUCTURE AND IMPROVED ANTISENSE PROPERTIES OF 2'-O-(2-METHOXYETHYL)-RNA
分子名称: MAGNESIUM ION, RNA (5'-R(*(C43)P*(G48)P*(C43)P*(G48)P*(A44)P*(A44)P*(U36)P*(U36)P*(C43)P*(G48)P*(C43)P*(G48))-3')
著者Teplova, M, Minasov, G, Tereshko, V, Inamati, G, Cook, P.D, Egli, M.
登録日1999-04-29
公開日1999-05-12
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structure and improved antisense properties of 2'-O-(2-methoxyethyl)-RNA.
Nat.Struct.Biol., 6, 1999
469D
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BU of 469d by Molmil
CRYSTAL STRUCTURE AND IMPROVED ANTISENSE PROPERTIES OF 2'-O-(2-METHOXYETHYL)-RNA
分子名称: MAGNESIUM ION, RNA (5'-R(*(C43)P*(G48)P*(C43)P*(G48)P*(A44)P*(A44)P*(U36)P*(U36)P*(C43)P*(G48)P*(C43)P*(G48))-3')
著者Teplova, M, Minasov, G, Tereshko, V, Inamati, G, Cook, P.D, Egli, M.
登録日1999-04-29
公開日1999-05-12
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal structure and improved antisense properties of 2'-O-(2-methoxyethyl)-RNA.
Nat.Struct.Biol., 6, 1999
3EY2
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BU of 3ey2 by Molmil
A Conformational Transition in the Structure of a 2'-Thiomethyl-Modified DNA Visualized at High Resolution
分子名称: 5'-D(*GP*CP*GP*TP*AP*(USM)P*AP*CP*GP*C)-3', N-methylpropane-1,3-diamine
著者Egli, M, Pallan, P.S.
登録日2008-10-17
公開日2009-04-28
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.04 Å)
主引用文献A conformational transition in the structure of a 2'-thiomethyl-modified DNA visualized at high resolution.
Chem.Commun.(Camb.), 15, 2009
3EY3
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BU of 3ey3 by Molmil
A Conformational Transition in the Structure of a 2'-Thiomethyl-Modified DNA Visualized at High Resolution
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 5'-D(*CP*GP*CP*GP*AP*AP*(USM)P*(USM)P*CP*GP*CP*G)-3', STRONTIUM ION
著者Egli, M, Pallan, P.S.
登録日2008-10-17
公開日2009-04-28
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献A conformational transition in the structure of a 2'-thiomethyl-modified DNA visualized at high resolution.
Chem.Commun.(Camb.), 15, 2009
3EY1
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A Conformational Transition in the Structure of a 2'-Thiomethyl-Modified DNA Visualized at High Resolution
分子名称: 5'-D(*CP*GP*CP*GP*AP*AP*(USM)P*(USM)P*CP*GP*CP*G)-3', GLYCEROL, Ribonuclease H
著者Egli, M, Pallan, P.S.
登録日2008-10-17
公開日2009-04-28
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献A conformational transition in the structure of a 2'-thiomethyl-modified DNA visualized at high resolution.
Chem.Commun.(Camb.), 15, 2009
2G92
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Crystal Structure Analysis of the RNA Dodecamer CGC-(NF2)-AAUUAGCG, with an Incorporated 2,4-Difluorotoluyl Residue (NF2)
分子名称: 5'-R(*CP*GP*CP*(NF2)P*AP*AP*UP*UP*AP*GP*CP*G)-3'
著者Egli, M, Li, F.
登録日2006-03-04
公開日2006-04-18
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.61 Å)
主引用文献Gene silencing activity of siRNAs with a ribo-difluorotoluyl nucleotide.
Acs Chem.Biol., 1, 2006
7JJE
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BU of 7jje by Molmil
Sarcin-ricin loop with guanosine dithiophosphate residue.
分子名称: RNA (27-MER)
著者Pallan, P.S, Egli, M, Harp, J.M.
登録日2020-07-25
公開日2020-12-23
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献Incorporating a Thiophosphate Modification into a Common RNA Tetraloop Motif Causes an Unanticipated Stability Boost.
Biochemistry, 59, 2020
7JJF
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BU of 7jjf by Molmil
Sarcin-ricin loop with modified residue.
分子名称: MAGNESIUM ION, RNA/DNA (27-mer)
著者Harp, J.M, Pallan, P.S, Egli, M.
登録日2020-07-25
公開日2020-12-23
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Incorporating a Thiophosphate Modification into a Common RNA Tetraloop Motif Causes an Unanticipated Stability Boost.
Biochemistry, 59, 2020
7JJD
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Sarcin-ricin loop with guanosine monothiophosphate residue.
分子名称: RNA (27-MER)
著者Pallan, P.S, Egli, M, Harp, J.M.
登録日2020-07-25
公開日2020-12-23
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.21 Å)
主引用文献Incorporating a Thiophosphate Modification into a Common RNA Tetraloop Motif Causes an Unanticipated Stability Boost.
Biochemistry, 59, 2020
2FIL
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BU of 2fil by Molmil
Crystal Structure Analysis of the A-DNA Decamer GCGT-2'OMeA-faT-ACGC, with Incorporated 2'-O-Methylated-Adenosine (2'OMeA) and 2'-Fluoroarabino-Thymidine (faT)
分子名称: 5'-D(*GP*CP*GP*TP*(A2M)P*(TAF)P*AP*CP*GP*C)-3', COBALT HEXAMMINE(III)
著者Egli, M, Li, F.
登録日2005-12-29
公開日2006-05-23
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献2'-Fluoroarabino- and arabinonucleic acid show different conformations, resulting in deviating RNA affinities and processing of their heteroduplexes with RNA by RNase H.
Biochemistry, 45, 2006
2FII
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Crystal Structure Analysis of the B-DNA Dodecamer CGCGAAT-aU-CGCG, with Incorporated Arabino-Uridin (aU)
分子名称: 5'-D(*CP*GP*CP*GP*AP*AP*TP*(UAR)P*CP*GP*CP*G)-3', MAGNESIUM ION
著者Egli, M, Li, F.
登録日2005-12-29
公開日2006-05-23
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.24 Å)
主引用文献2'-Fluoroarabino- and arabinonucleic acid show different conformations, resulting in deviating RNA affinities and processing of their heteroduplexes with RNA by RNase H.
Biochemistry, 45, 2006

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