7YVE
| Omicron BA.4/5 SARS-CoV-2 S in complex with TH027 Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, TH027 Fab heavy chain, ... | 著者 | Guo, Y, Zhang, G, Liang, J, Liu, F, Rao, Z. | 登録日 | 2022-08-19 | 公開日 | 2023-06-28 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Discovery and characterization of potent pan-variant SARS-CoV-2 neutralizing antibodies from individuals with Omicron breakthrough infection. Nat Commun, 14, 2023
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7YVH
| Omicron BA.4/5 SARS-CoV-2 S RBD in complex with TH132 Fab | 分子名称: | Spike glycoprotein, TH132 Fab heavy chain, TH132 Fab light chain | 著者 | Guo, Y, Zhang, G, Liang, J, Liu, F, Rao, Z. | 登録日 | 2022-08-19 | 公開日 | 2023-06-28 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Discovery and characterization of potent pan-variant SARS-CoV-2 neutralizing antibodies from individuals with Omicron breakthrough infection. Nat Commun, 14, 2023
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7YVM
| Omicron BA.4/5 SARS-CoV-2 S RBD in complex with TH272 Fab | 分子名称: | Spike glycoprotein, TH281 Fab heavy chain, TH281 Fab light chain | 著者 | Guo, Y, Zhang, G, Liang, J, Liu, F, Rao, Z. | 登録日 | 2022-08-19 | 公開日 | 2023-06-28 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Discovery and characterization of potent pan-variant SARS-CoV-2 neutralizing antibodies from individuals with Omicron breakthrough infection. Nat Commun, 14, 2023
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7YVF
| Omicron BA.4/5 SARS-CoV-2 S RBD in complex with TH027 Fab | 分子名称: | Spike glycoprotein, TH027 Fab heavy chain, TH027 Fab light chain | 著者 | Guo, Y, Zhang, G, Liang, J, Liu, F, Rao, Z. | 登録日 | 2022-08-19 | 公開日 | 2023-06-28 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Discovery and characterization of potent pan-variant SARS-CoV-2 neutralizing antibodies from individuals with Omicron breakthrough infection. Nat Commun, 14, 2023
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7YVJ
| Omicron BA.4/5 SARS-CoV-2 S RBD in complex with TH236 Fab | 分子名称: | Spike glycoprotein, TH236 Fab heavy chain, TH236 Fab light chain | 著者 | Guo, Y, Zhang, G, Liang, J, Liu, F, Rao, Z. | 登録日 | 2022-08-19 | 公開日 | 2023-06-28 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Discovery and characterization of potent pan-variant SARS-CoV-2 neutralizing antibodies from individuals with Omicron breakthrough infection. Nat Commun, 14, 2023
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7YVL
| Omicron BA.4/5 SARS-CoV-2 S RBD in complex with TH272 Fab | 分子名称: | Spike glycoprotein, TH272 Fab heavy chain, TH272 Fab light chain | 著者 | Guo, Y, Zhang, G, Liang, J, Liu, F, Rao, Z. | 登録日 | 2022-08-19 | 公開日 | 2023-06-28 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Discovery and characterization of potent pan-variant SARS-CoV-2 neutralizing antibodies from individuals with Omicron breakthrough infection. Nat Commun, 14, 2023
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7YVI
| Omicron BA.4/5 SARS-CoV-2 S in complex with TH236 Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, TH236 Fab heavy chain, ... | 著者 | Guo, Y, Zhang, G, Liang, J, Liu, F, Rao, Z. | 登録日 | 2022-08-19 | 公開日 | 2023-06-28 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Discovery and characterization of potent pan-variant SARS-CoV-2 neutralizing antibodies from individuals with Omicron breakthrough infection. Nat Commun, 14, 2023
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7CAF
| Mycobacterium smegmatis LpqY-SugABC complex in the pre-translocation state | 分子名称: | ABC sugar transporter, permease component, ABC transporter, ... | 著者 | Liu, F, Liang, J, Zhang, B, Gao, Y, Yang, X, Hu, T, Rao, Z. | 登録日 | 2020-06-08 | 公開日 | 2020-12-02 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural basis of trehalose recycling by the ABC transporter LpqY-SugABC. Sci Adv, 6, 2020
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7CAG
| Mycobacterium smegmatis LpqY-SugABC complex in the catalytic intermediate state | 分子名称: | ABC sugar transporter, permease component, ABC transporter, ... | 著者 | Liu, F, Liang, J, Zhang, B, Gao, Y, Yang, X, Hu, T. | 登録日 | 2020-06-08 | 公開日 | 2020-12-02 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.78 Å) | 主引用文献 | Structural basis of trehalose recycling by the ABC transporter LpqY-SugABC. Sci Adv, 6, 2020
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7CAD
| Mycobacterium smegmatis SugABC complex | 分子名称: | ABC sugar transporter, permease component, ABC transporter, ... | 著者 | Liu, F, Liang, J, Zhang, B, Gao, Y, Yang, X, Hu, T, Rao, Z. | 登録日 | 2020-06-08 | 公開日 | 2020-12-02 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.41 Å) | 主引用文献 | Structural basis of trehalose recycling by the ABC transporter LpqY-SugABC. Sci Adv, 6, 2020
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7CAE
| Mycobacterium smegmatis LpqY-SugABC complex in the resting state | 分子名称: | ABC sugar transporter, permease component, ABC transporter, ... | 著者 | Liu, F, Liang, J, Zhang, B, Gao, Y, Yang, X, Hu, T, Rao, Z. | 登録日 | 2020-06-08 | 公開日 | 2020-12-02 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.44 Å) | 主引用文献 | Structural basis of trehalose recycling by the ABC transporter LpqY-SugABC. Sci Adv, 6, 2020
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8VW5
| Crystal structure of Cbl-b TKB bound to compound 2 | 分子名称: | CALCIUM ION, E3 ubiquitin-protein ligase CBL-B, MAGNESIUM ION, ... | 著者 | Yu, C, Murray, J, Hsu, P.L. | 登録日 | 2024-01-31 | 公開日 | 2024-07-03 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | Optimization of a Novel DEL Hit That Binds in the Cbl-b SH2 Domain and Blocks Substrate Binding. Acs Med.Chem.Lett., 15, 2024
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8VW4
| Crystal structure of Cbl-b TKB bound to compound 26 | 分子名称: | (7-methoxy-2-{2-[(1S,3S,4S)-3-(3-methoxy-2-methyl-5-nitrophenyl)-1-methyl-5-oxo-1,5-dihydroimidazo[1,5-a]pyridin-2(3H)-yl]-2-oxoethoxy}quinolin-8-yl)acetic acid, DI(HYDROXYETHYL)ETHER, E3 ubiquitin-protein ligase CBL-B, ... | 著者 | Yu, C, Murray, J, Hsu, P.L. | 登録日 | 2024-01-31 | 公開日 | 2024-07-03 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Optimization of a Novel DEL Hit That Binds in the Cbl-b SH2 Domain and Blocks Substrate Binding. Acs Med.Chem.Lett., 15, 2024
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6KK0
| Crystal structure of PDE4D catalytic domain complexed with compound 4e | 分子名称: | 7-[8-methoxy-2,2-dimethyl-7-(3-methylbut-2-enyl)-5-oxidanyl-6-oxidanylidene-pyrano[3,2-b]xanthen-9-yl]oxyheptanoic acid, MAGNESIUM ION, ZINC ION, ... | 著者 | Huang, Y.-Y, He, X, Luo, H.-B. | 登録日 | 2019-07-23 | 公開日 | 2020-03-18 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.20008755 Å) | 主引用文献 | Discovery and Optimization of alpha-Mangostin Derivatives as Novel PDE4 Inhibitors for the Treatment of Vascular Dementia. J.Med.Chem., 63, 2020
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6KJZ
| Crystal structure of PDE4D catalytic domain complexed with compound 1 | 分子名称: | 5,9-dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methylbut-2-en-1-yl)-3,4-dihydro-2H,6H-pyrano[3,2-b]xanthen-6-one, MAGNESIUM ION, ZINC ION, ... | 著者 | Huang, Y.-Y, He, X, Luo, H.-B. | 登録日 | 2019-07-23 | 公開日 | 2020-03-18 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.200001 Å) | 主引用文献 | Discovery and Optimization of alpha-Mangostin Derivatives as Novel PDE4 Inhibitors for the Treatment of Vascular Dementia. J.Med.Chem., 63, 2020
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5WAL
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5WEV
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4GJ2
| Tyk2 (JH1) in complex with 2,6-dichloro-N-[2-({[(1R,2R)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]benzamide | 分子名称: | 2,6-dichloro-N-[2-({[(1R,2R)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]benzamide, Non-receptor tyrosine-protein kinase TYK2 | 著者 | Ultsch, M.H. | 登録日 | 2012-08-09 | 公開日 | 2013-05-29 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Lead Optimization of a 4-Aminopyridine Benzamide Scaffold To Identify Potent, Selective, and Orally Bioavailable TYK2 Inhibitors. J.Med.Chem., 56, 2013
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4GII
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4GJ3
| Tyk2 (JH1) in complex with 2,6-dichloro-4-cyano-N-[2-({[(1R,2R)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]benzamide | 分子名称: | 2,6-dichloro-4-cyano-N-[2-({[(1R,2R)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]benzamide, Non-receptor tyrosine-protein kinase TYK2 | 著者 | Ultsch, M.H. | 登録日 | 2012-08-09 | 公開日 | 2013-05-29 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Lead Optimization of a 4-Aminopyridine Benzamide Scaffold To Identify Potent, Selective, and Orally Bioavailable TYK2 Inhibitors. J.Med.Chem., 56, 2013
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4GMY
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4GIH
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4GFM
| JAK2 kinase (JH1 domain) with 2,6-DICHLORO-N-(2-OXO-2,5-DIHYDROPYRIDIN-4-YL)BENZAMIDE | 分子名称: | 2,6-dichloro-N-(2-oxo-2,5-dihydropyridin-4-yl)benzamide, Tyrosine-protein kinase JAK2 | 著者 | Eigenbrot, C, Ultsch, M. | 登録日 | 2012-08-03 | 公開日 | 2013-06-19 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Lead identification of novel and selective TYK2 inhibitors. Eur.J.Med.Chem., 67, 2013
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4GFO
| TYK2 kinase (JH1 domain) with 2,6-DICHLORO-N-(2-OXO-2,5-DIHYDROPYRIDIN-4-YL)BENZAMIDE | 分子名称: | 1,2-ETHANEDIOL, 2,6-dichloro-N-(2-oxo-2,5-dihydropyridin-4-yl)benzamide, GLYCEROL, ... | 著者 | Eigenbrot, C, Ultsch, M. | 登録日 | 2012-08-03 | 公開日 | 2013-06-19 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Lead identification of novel and selective TYK2 inhibitors. Eur.J.Med.Chem., 67, 2013
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5V1A
| Structure of S. cerevisiae Ulp2:Csm1 complex | 分子名称: | Monopolin complex subunit CSM1, Ubiquitin-like-specific protease 2 | 著者 | Singh, N, Corbett, K.D. | 登録日 | 2017-03-01 | 公開日 | 2017-05-17 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | 主引用文献 | Recruitment of a SUMO isopeptidase to rDNA stabilizes silencing complexes by opposing SUMO targeted ubiquitin ligase activity. Genes Dev., 31, 2017
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