7LFT
 
 | | Cryo-EM structure of human Apo CNGA1 channel in K+/Ca2+ | | 分子名称: | 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL, POTASSIUM ION, ... | | 著者 | Xue, J, Han, Y, Jiang, Y. | | 登録日 | 2021-01-18 | | 公開日 | 2021-03-10 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Structural mechanisms of gating and selectivity of human rod CNGA1 channel.
Neuron, 109, 2021
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7LFX
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7LFW
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7LG1
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7N7P
 | | Cryo-EM structure of human TMEM120A | | 分子名称: | COENZYME A, Ion channel TACAN | | 著者 | Xue, J, Han, Y, Jiang, Y. | | 登録日 | 2021-06-10 | | 公開日 | 2021-09-01 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.24 Å) | | 主引用文献 | TMEM120A is a coenzyme A-binding membrane protein with structural similarities to ELOVL fatty acid elongase.
Elife, 10, 2021
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6VP0
 | | Human Diacylglycerol Acyltransferase 1 in complex with oleoyl-CoA | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Diacylglycerol O-acyltransferase 1, Lauryl Maltose Neopentyl Glycol, ... | | 著者 | Wang, L, Qian, H, Han, Y, Nian, Y, Ren, Z, Zhang, H, Hu, L, Prasad, B.V.V, Yan, N, Zhou, M. | | 登録日 | 2020-02-01 | | 公開日 | 2020-05-13 | | 最終更新日 | 2023-12-13 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structure and mechanism of human diacylglycerol O-acyltransferase 1.
Nature, 581, 2020
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1S2U
 | | Crystal structure of the D58A phosphoenolpyruvate mutase mutant protein | | 分子名称: | DI(HYDROXYETHYL)ETHER, Phosphoenolpyruvate phosphomutase | | 著者 | Liu, S, Lu, Z, Han, Y, Jia, Y, Howard, A, Dunaway-Mariano, D, Herzberg, O. | | 登録日 | 2004-01-11 | | 公開日 | 2004-05-04 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Conformational Flexibility of PEP Mutase
Biochemistry, 43, 2004
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1S2W
 | | Crystal structure of phosphoenolpyruvate mutase in high ionic strength | | 分子名称: | Phosphoenolpyruvate phosphomutase, SULFATE ION | | 著者 | Liu, S, Lu, Z, Han, Y, Jia, Y, Howard, A, Dunaway-Mariano, D, Herzberg, O. | | 登録日 | 2004-01-11 | | 公開日 | 2004-05-04 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | | 主引用文献 | Conformational Flexibility of PEP Mutase
Biochemistry, 43, 2004
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1S2T
 | | Crystal Structure Of Apo Phosphoenolpyruvate Mutase | | 分子名称: | Phosphoenolpyruvate phosphomutase | | 著者 | Liu, S, Lu, Z, Han, Y, Jia, Y, Howard, A, Dunaway-Mariano, D, Herzberg, O. | | 登録日 | 2004-01-11 | | 公開日 | 2004-05-04 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Conformational Flexibility of PEP Mutase
Biochemistry, 43, 2004
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1S2V
 | | Crystal structure of phosphoenolpyruvate mutase complexed with Mg(II) | | 分子名称: | MAGNESIUM ION, Phosphoenolpyruvate phosphomutase | | 著者 | Liu, S, Lu, Z, Han, Y, Jia, Y, Howard, A, Dunaway-Mariano, D, Herzberg, O. | | 登録日 | 2004-01-11 | | 公開日 | 2004-05-04 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Conformational Flexibility of PEP Mutase
Biochemistry, 43, 2004
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8FYF
 | | Human TMEM175-LAMP1 transmembrane domain only complex | | 分子名称: | Endosomal/lysosomal potassium channel TMEM175, Lysosome-associated membrane glycoprotein 1 | | 著者 | Zhang, J.Y, Zeng, W.Z, Han, Y, Jiang, Y.X. | | 登録日 | 2023-01-26 | | 公開日 | 2023-06-28 | | 最終更新日 | 2023-08-02 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel.
Mol.Cell, 83, 2023
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8FY5
 | | Human TMEM175-LAMP1 full-length complex | | 分子名称: | Endosomal/lysosomal potassium channel TMEM175, Lysosome-associated membrane glycoprotein 1 | | 著者 | Zhang, J.Y, Zeng, W.Z, Han, Y, Jiang, Y.X. | | 登録日 | 2023-01-25 | | 公開日 | 2023-06-28 | | 最終更新日 | 2023-08-02 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel.
Mol.Cell, 83, 2023
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1XG3
 | | Crystal structure of the C123S 2-methylisocitrate lyase mutant from Escherichia coli in complex with the reaction product, Mg(II)-pyruvate and succinate | | 分子名称: | MAGNESIUM ION, PYRUVIC ACID, Probable methylisocitrate lyase, ... | | 著者 | Liu, S, Lu, Z, Han, Y, Melamud, E, Dunaway-Mariano, D, Herzberg, O. | | 登録日 | 2004-09-16 | | 公開日 | 2005-03-01 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal Structures of 2-Methylisocitrate Lyase in Complex with Product and with Isocitrate Inhibitor Provide Insight into Lyase Substrate Specificity, Catalysis and Evolution
Biochemistry, 44, 2005
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1XG4
 | | Crystal Structure of the C123S 2-Methylisocitrate Lyase Mutant from Escherichia coli in complex with the inhibitor isocitrate | | 分子名称: | ISOCITRIC ACID, MAGNESIUM ION, Probable methylisocitrate lyase | | 著者 | Liu, S, Lu, Z, Han, Y, Melamud, E, Dunaway-Mariano, D, Herzberg, O. | | 登録日 | 2004-09-16 | | 公開日 | 2005-03-01 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Crystal Structures of 2-Methylisocitrate Lyase in Complex with Product and with Isocitrate Inhibitor Provide Insight into Lyase Substrate Specificity, Catalysis and Evolution
Biochemistry, 44, 2005
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8SYN
 | | Human VPS35L/VPS29/VPS26C Complex | | 分子名称: | VPS35 endosomal protein-sorting factor-like, Vacuolar protein sorting-associated protein 26C, Vacuolar protein sorting-associated protein 29 | | 著者 | Chen, Z, Chen, B, Burstein, E, Han, Y. | | 登録日 | 2023-05-25 | | 公開日 | 2023-11-01 | | 最終更新日 | 2023-12-20 | | 実験手法 | ELECTRON MICROSCOPY (2.94 Å) | | 主引用文献 | Structural organization of the retriever-CCC endosomal recycling complex.
Nat.Struct.Mol.Biol., 2023
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8SYM
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8SYO
 | | Human Retriever VPS35L/VPS29/VPS26C Complex (Composite Map) | | 分子名称: | VPS35 endosomal protein-sorting factor-like, Vacuolar protein sorting-associated protein 26C, Vacuolar protein sorting-associated protein 29 | | 著者 | Chen, Z, Chen, B, Burstein, E, Han, Y. | | 登録日 | 2023-05-25 | | 公開日 | 2023-11-01 | | 最終更新日 | 2023-12-20 | | 実験手法 | ELECTRON MICROSCOPY (2.94 Å) | | 主引用文献 | Structural organization of the retriever-CCC endosomal recycling complex.
Nat.Struct.Mol.Biol., 2023
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6K3B
 | | Crystal structure of Lpg2147-Lpg2149 complex | | 分子名称: | Lpg2147, Uncharacterized protein | | 著者 | Mu, Y, Wang, Y, Han, Y, Li, D, Feng, Y. | | 登録日 | 2019-05-17 | | 公開日 | 2020-04-01 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.974 Å) | | 主引用文献 | Structural insights into the mechanism and inhibition of transglutaminase-induced ubiquitination by the Legionella effector MavC.
Nat Commun, 11, 2020
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6KFP
 | | Crystal structure of MavC ternary complex | | 分子名称: | MavC, Ubiquitin-40S ribosomal protein S27a, Ubiquitin-conjugating enzyme E2 N | | 著者 | Mu, Y, Wang, Y, Han, Y, Li, D, Feng, Y. | | 登録日 | 2019-07-08 | | 公開日 | 2020-04-01 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.92 Å) | | 主引用文献 | Structural insights into the mechanism and inhibition of transglutaminase-induced ubiquitination by the Legionella effector MavC.
Nat Commun, 11, 2020
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2ALF
 | | crystal structure of human CypA mutant K131A | | 分子名称: | MAGNESIUM ION, Peptidyl-prolyl cis-trans isomerase A | | 著者 | Hu, H, Huang, C.-Q, Liu, H.-L, Han, Y, Chen, M.-E, Yu, L, Bi, R.-C. | | 登録日 | 2005-08-05 | | 公開日 | 2005-08-23 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Nuclease activity of Cyclophilin A and its structural basis
TO BE PUBLISHED
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8ISS
 | | Cryo-EM structure of wild-type human tRNA Splicing Endonuclease Complex bound to pre-tRNA-ARG at 3.19 A resolution | | 分子名称: | MAGNESIUM ION, RNA (88-MER), tRNA-splicing endonuclease subunit Sen15, ... | | 著者 | Sun, Y, Zhang, Y, Yuan, L, Han, Y. | | 登録日 | 2023-03-21 | | 公開日 | 2023-10-18 | | 実験手法 | ELECTRON MICROSCOPY (3.19 Å) | | 主引用文献 | Recognition and cleavage mechanism of intron-containing pre-tRNA by human TSEN endonuclease complex.
Nat Commun, 14, 2023
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4NUX
 | | Structure of receptor A | | 分子名称: | Interleukin-17 receptor A | | 著者 | Zhang, B, Han, Y, Deng, J. | | 登録日 | 2013-12-04 | | 公開日 | 2014-05-14 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.295 Å) | | 主引用文献 | Structure of the unique SEFIR domain from human interleukin 17 receptor A reveals a composite ligand-binding site containing a conserved alpha-helix for Act1 binding and IL-17 signaling.
Acta Crystallogr.,Sect.D, 70, 2014
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4AOJ
 | | Human TrkA in complex with the inhibitor AZ-23 | | 分子名称: | 5-chloranyl-N2-[(1S)-1-(5-fluoranylpyridin-2-yl)ethyl]-N4-(3-propan-2-yloxy-1H-pyrazol-5-yl)pyrimidine-2,4-diamine, HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR, ZINC ION | | 著者 | Wang, T, Lamb, M.L, Block, M.H, Davies, A.M, Han, Y, Hoffmann, E, Ioannidis, S, Josey, J.A, Liu, Z, Lyne, P.D, MacIntyre, T, Mohr, P.J, Omer, C.A, Sjogren, T, Thress, K, Wang, B, Wang, H, Yu, D, Zhang, H. | | 登録日 | 2012-03-28 | | 公開日 | 2012-08-15 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Discovery of Disubstituted Imidazo[4,5-B]Pyridines and Purines as Potent Trka Inhibitors
Acs Med.Chem.Lett., 3, 2012
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3U1R
 | | Structure Analysis of A New Psychrophilic Marine Protease | | 分子名称: | Alkaline metalloprotease, CALCIUM ION, ZINC ION | | 著者 | Zhang, S.-C, Sun, M, Tang, L, Wang, Q.-H, Hao, J.-H, Han, Y, Hu, X.-J, Zhou, M, Lin, S.-X. | | 登録日 | 2011-09-30 | | 公開日 | 2012-10-31 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structure analysis of a new psychrophilic marine protease.
Plos One, 6, 2011
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7XLZ
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