1XG4

Crystal Structure of the C123S 2-Methylisocitrate Lyase Mutant from Escherichia coli in complex with the inhibitor isocitrate

Summary for 1XG4

Entry DOI	10.2210/pdb1xg4/pdb
Related	1oqf 1xg3
Descriptor	Probable methylisocitrate lyase, MAGNESIUM ION, ISOCITRIC ACID, ... (4 entities in total)
Functional Keywords	2-methylisocitrate lyase-inhibitor complex, isocitrate, isocitrate lyase superfamily, lyase
Biological source	Escherichia coli
Total number of polymer chains	4
Total formula weight	128738.71
Authors	Liu, S.,Lu, Z.,Han, Y.,Melamud, E.,Dunaway-Mariano, D.,Herzberg, O. (deposition date: 2004-09-16, release date: 2005-03-01, Last modification date: 2023-08-23)
Primary citation	Liu, S.,Lu, Z.,Han, Y.,Melamud, E.,Dunaway-Mariano, D.,Herzberg, O. Crystal Structures of 2-Methylisocitrate Lyase in Complex with Product and with Isocitrate Inhibitor Provide Insight into Lyase Substrate Specificity, Catalysis and Evolution Biochemistry, 44:2949-2962, 2005 Cited by PubMed: 15723538 DOI: 10.1021/bi0479712 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation