8ISS

Cryo-EM structure of wild-type human tRNA Splicing Endonuclease Complex bound to pre-tRNA-ARG at 3.19 A resolution

Summary for 8ISS

• Entry DOI: 10.2210/pdb8iss/pdb
• EMDB information: 35694
• Descriptor: tRNA-splicing endonuclease subunit Sen15, tRNA-splicing endonuclease subunit Sen2, tRNA-splicing endonuclease subunit Sen34, ... (6 entities in total)
• Functional Keywords: trna splicing, tsen, cryo-em, endonuclease, structural protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 194699.10

Authors

Sun, Y.,Zhang, Y.,Yuan, L.,Han, Y. (deposition date: 2023-03-21, release date: 2023-10-18)

• Primary citation: Yuan, L.,Han, Y.,Zhao, J.,Zhang, Y.,Sun, Y.; Recognition and cleavage mechanism of intron-containing pre-tRNA by human TSEN endonuclease complex.; Nat Commun, 14:6071-6071, 2023; PubMed: 37770519; DOI: 10.1038/s41467-023-41845-y

Experimental method

ELECTRON MICROSCOPY (3.19 Å)