4BMW
| Crystal structure of the Streptomyces reticuli HbpS E78D, E81D double mutant | 分子名称: | EXTRACELLULAR HAEM-BINDING PROTEIN | 著者 | Wagener, S, Kursula, I, Wedderhoff, I, Groves, M.R, Ortiz de Orue Lucana, D. | 登録日 | 2013-05-11 | 公開日 | 2013-09-25 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Iron Binding at Specific Sites within the Octameric Hbps Protects Streptomycetes from Iron-Mediated Oxidative Stress. Plos One, 8, 2013
|
|
7MMO
| LY-CoV1404 neutralizing antibody against SARS-CoV-2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, LY-CoV1404 Fab heavy chain, LY-CoV1404 Fab light chain, ... | 著者 | Hendle, J, Pustilnik, A, Sauder, J.M, Coleman, K.A, Boyles, J.S, Dickinson, C.D. | 登録日 | 2021-04-30 | 公開日 | 2021-05-12 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.427 Å) | 主引用文献 | LY-CoV1404 (bebtelovimab) potently neutralizes SARS-CoV-2 variants. Biorxiv, 2022
|
|
6DO4
| KLHDC2 ubiquitin ligase in complex with SelS C-end degron | 分子名称: | Kelch domain-containing protein 2, SELS C-END DEGRON | 著者 | Rusnac, D.V, Lin, H.C, Yen, H.C.S, Zheng, N. | 登録日 | 2018-06-08 | 公開日 | 2018-12-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Recognition of the Diglycine C-End Degron by CRL2KLHDC2Ubiquitin Ligase. Mol. Cell, 72, 2018
|
|
6DO3
| KLHDC2 ubiquitin ligase in complex with SelK C-end degron | 分子名称: | Kelch domain-containing protein 2, SelK C-end Degron | 著者 | Rusnac, D.V, Lin, H.C, Yen, H.C.S, Zheng, N. | 登録日 | 2018-06-08 | 公開日 | 2018-12-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.165 Å) | 主引用文献 | Recognition of the Diglycine C-End Degron by CRL2KLHDC2Ubiquitin Ligase. Mol. Cell, 72, 2018
|
|
3IKA
| |
5NTD
| Structure of Leucyl aminopeptidase from Trypanosoma brucei in complex with Bestatin | 分子名称: | 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, BICARBONATE ION, ... | 著者 | Timm, J, Wilson, K. | 登録日 | 2017-04-27 | 公開日 | 2017-08-02 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural Characterization of Acidic M17 Leucine Aminopeptidases from the TriTryps and Evaluation of Their Role in Nutrient Starvation inTrypanosoma brucei. mSphere, 2, 2018
|
|
5NTH
| |
5NSK
| |
5NTF
| |
5NSM
| |
5NSQ
| |
5NTG
| |
7Q4A
| Toxoplasma gondii PRP4K kinase domain (L715F) bound to altiratinib | 分子名称: | Altiratinib, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | 著者 | Swale, C, Bellini, V, Bowler, M. | 登録日 | 2021-10-29 | 公開日 | 2022-08-03 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | 主引用文献 | Altiratinib blocks Toxoplasma gondii and Plasmodium falciparum development by selectively targeting a spliceosome kinase. Sci Transl Med, 14, 2022
|
|
5C9C
| CRYSTAL STRUCTURE OF BRAF(V600E) IN COMPLEX WITH LY3009120 COMPND | 分子名称: | 1-(3,3-dimethylbutyl)-3-{2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl}urea, CHLORIDE ION, Serine/threonine-protein kinase B-raf | 著者 | Edwards, T, Abendroth, J, Chun, L. | 登録日 | 2015-06-26 | 公開日 | 2015-07-15 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Inhibition of RAF Isoforms and Active Dimers by LY3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers. Cancer Cell, 28, 2015
|
|
8C86
| Crystal structure of human transthyretin in complex with 3-O-methyltolcapone analogue 2 | 分子名称: | (2,4-dimethylphenyl)-(3-methoxy-5-nitro-4-oxidanyl-phenyl)methanone, Transthyretin | 著者 | Poonsiri, T, Benini, S, Loconte, V, Cianci, M. | 登録日 | 2023-01-18 | 公開日 | 2024-01-17 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | 3-O-Methyltolcapone and Its Lipophilic Analogues Are Potent Inhibitors of Transthyretin Amyloidogenesis with High Permeability and Low Toxicity. Int J Mol Sci, 25, 2023
|
|
8C85
| Crystal structure of human transthyretin in complex with 3-O-methyltolcapone analogue 1 | 分子名称: | (3,5-dimethylphenyl)-(3-methoxy-5-nitro-4-oxidanyl-phenyl)methanone, Transthyretin | 著者 | Poonsiri, T, Benini, S, Loconte, V, Cianci, M. | 登録日 | 2023-01-18 | 公開日 | 2024-01-17 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.19 Å) | 主引用文献 | 3-O-Methyltolcapone and Its Lipophilic Analogues Are Potent Inhibitors of Transthyretin Amyloidogenesis with High Permeability and Low Toxicity. Int J Mol Sci, 25, 2023
|
|
8UXS
| |
6DO5
| KLHDC2 ubiquitin ligase in complex with USP1 C-end degron | 分子名称: | Kelch domain-containing protein 2, USP1 C-END DEGRON | 著者 | Rusnac, D.V, Lin, H.C, Yen, H.C.S, Zheng, N. | 登録日 | 2018-06-08 | 公開日 | 2018-12-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Recognition of the Diglycine C-End Degron by CRL2KLHDC2Ubiquitin Ligase. Mol. Cell, 72, 2018
|
|
7ZE9
| Structure of an AA16 LPMO-like protein | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, COPPER (II) ION, ... | 著者 | Huang, Z, Banerjee, S, Muderspach, S.J, Sun, P, van Berkel, W.J.H, Kabel, M.A, Lo Leggio, L. | 登録日 | 2022-03-30 | 公開日 | 2023-03-15 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.646 Å) | 主引用文献 | AA16 Oxidoreductases Boost Cellulose-Active AA9 Lytic Polysaccharide Monooxygenases from Myceliophthora thermophila. Acs Catalysis, 13, 2023
|
|
4LN9
| |
4JZX
| Crystal Structure of Leshmaniasis major Farnesyl diphosphate synthase in complex with 3-BUTYL-1-(2,2-DIPHOSPHONOETHYL)PYRIDINIUM, IPP and Ca2+ | 分子名称: | 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, 3-butyl-1-(2,2-diphosphonoethyl)pyridinium, CALCIUM ION, ... | 著者 | Aripirala, S, Gabelli, S, Amzel, L.M. | 登録日 | 2013-04-03 | 公開日 | 2014-03-05 | 最終更新日 | 2017-11-15 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural and thermodynamic basis of the inhibition of Leishmania major farnesyl diphosphate synthase by nitrogen-containing bisphosphonates. Acta Crystallogr.,Sect.D, 70, 2014
|
|
4R5S
| Crystal structure of EGFR 696-1022 L858R in complex with FIIN-3 | 分子名称: | Epidermal growth factor receptor, N-[4-({[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl](6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino}methyl)phenyl]propanamide | 著者 | Zhu, S.J, Yun, C.H. | 登録日 | 2014-08-22 | 公開日 | 2014-11-12 | 最終更新日 | 2022-08-24 | 実験手法 | X-RAY DIFFRACTION (3.001 Å) | 主引用文献 | Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors. Proc.Natl.Acad.Sci.USA, 111, 2014
|
|
4QQC
| Crystal Structure of FGF Receptor (FGFR) 4 Kinase Domain in Complex with FIIN-2, an Irreversible Tyrosine Kinase Inhibitor Capable of Overcoming FGFR Kinase Gate-Keeper Mutations | 分子名称: | Fibroblast growth factor receptor 4, N-(4-{[3-(3,5-dimethoxyphenyl)-7-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl}phenyl)propanamide, SULFATE ION | 著者 | Huang, Z, Mohammadi, M. | 登録日 | 2014-06-27 | 公開日 | 2014-10-29 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors. Proc.Natl.Acad.Sci.USA, 111, 2014
|
|
4R6V
| Crystal Structure of FGF Receptor (FGFR) 4 Kinase Harboring the V550L Gate-Keeper Mutation in Complex with FIIN-3, an Irreversible Tyrosine Kinase Inhibitor Capable of Overcoming FGFR kinase Gate-Keeper Mutations | 分子名称: | Fibroblast growth factor receptor 4, N-[4-({[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl](6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino}methyl)phenyl]propanamide, SULFATE ION | 著者 | Huang, Z, Mohammadi, M. | 登録日 | 2014-08-26 | 公開日 | 2014-10-29 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.353 Å) | 主引用文献 | Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors. Proc.Natl.Acad.Sci.USA, 111, 2014
|
|
4N08
| |