2O7V
 
 | | Carboxylesterase AeCXE1 from Actinidia eriantha covalently inhibited by paraoxon | | 分子名称: | CXE carboxylesterase, DIETHYL PHOSPHONATE | | 著者 | Ileperuma, N.R, Marshall, S.D, Squire, C.J, Baker, H.M, Oakeshott, J.G, Russell, R.J, Plummer, K.M, Newcomb, R.D, Baker, E.N. | | 登録日 | 2006-12-11 | | 公開日 | 2007-02-27 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | High-Resolution Crystal Structure of Plant Carboxylesterase AeCXE1, from Actinidia eriantha, and Its Complex with a High-Affinity Inhibitor Paraoxon.
Biochemistry, 46, 2007
|
|
2QKX
 | | N-acetyl glucosamine 1-phosphate uridyltransferase from Mycobacterium tuberculosis complex with N-acetyl glucosamine 1-phosphate | | 分子名称: | 2-acetamido-2-deoxy-1-O-phosphono-alpha-D-glucopyranose, Bifunctional protein glmU | | 著者 | Zhang, Z, Squire, C.J, Baker, E.N, TB Structural Genomics Consortium (TBSGC) | | 登録日 | 2007-07-11 | | 公開日 | 2008-07-15 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Structure and function of GlmU from Mycobacterium tuberculosis.
Acta Crystallogr.,Sect.D, 65, 2009
|
|
5E5Q
 | | Racemic snakin-1 in P21/c | | 分子名称: | Snakin-1 | | 著者 | Yeung, H, Squire, C.J, Yosaatmadja, Y, Panjikar, S, Baker, E.N, Harris, P.W.R, Brimble, M.A. | | 登録日 | 2015-10-09 | | 公開日 | 2016-05-18 | | 最終更新日 | 2016-07-20 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Radiation Damage and Racemic Protein Crystallography Reveal the Unique Structure of the GASA/Snakin Protein Superfamily.
Angew.Chem.Int.Ed.Engl., 55, 2016
|
|
5E5T
 | | Quasi-racemic snakin-1 in P1 after radiation damage | | 分子名称: | 1,2-ETHANEDIOL, D- snakin-1, FORMIC ACID, ... | | 著者 | Yeung, H, Squire, C.J, Yosaatmadja, Y, Panjikar, S, Baker, E.N, Harris, P.W.R, Brimble, M.A. | | 登録日 | 2015-10-09 | | 公開日 | 2016-05-18 | | 最終更新日 | 2016-07-20 | | 実験手法 | X-RAY DIFFRACTION (1.572 Å) | | 主引用文献 | Radiation Damage and Racemic Protein Crystallography Reveal the Unique Structure of the GASA/Snakin Protein Superfamily.
Angew.Chem.Int.Ed.Engl., 55, 2016
|
|
5E5Y
 | | Quasi-racemic snakin-1 in P1 before radiation damage | | 分子名称: | 1,2-ETHANEDIOL, D- snakin-1, FORMIC ACID, ... | | 著者 | Yeung, H, Squire, C.J, Yosaatmadja, Y, Panjikar, S, Baker, E.N, Harris, P.W.R, Brimble, M.A. | | 登録日 | 2015-10-09 | | 公開日 | 2016-05-18 | | 最終更新日 | 2016-07-20 | | 実験手法 | X-RAY DIFFRACTION (1.506 Å) | | 主引用文献 | Radiation Damage and Racemic Protein Crystallography Reveal the Unique Structure of the GASA/Snakin Protein Superfamily.
Angew.Chem.Int.Ed.Engl., 55, 2016
|
|
3HPX
 | |
3HQ1
 | |
7UC3
 | |
7UI8
 | |
3HPZ
 | |
3HPS
 | |
5TCV
 | |
5TCW
 | |
5U6F
 | |
5TTD
 | | Minor pilin FctB from S. pyogenes with engineered intramolecular isopeptide bond | | 分子名称: | FORMIC ACID, Maltose-binding periplasmic protein,Pilin isopeptide linkage domain protein, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | | 著者 | Young, P.G, Kwon, H, Squire, C.J, Baker, E.N. | | 登録日 | 2016-11-02 | | 公開日 | 2017-03-01 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Engineering a Lys-Asn isopeptide bond into an immunoglobulin-like protein domain enhances its stability.
Sci Rep, 7, 2017
|
|
5UQ0
 | |
5UR1
 | | FGFR1 kinase domain complex with SN37333 in reversible binding mode | | 分子名称: | 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{1-[4-(dimethylamino)but-2-enoyl]piperidin-4-yl}-7-(phenylamino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one, Fibroblast growth factor receptor 1 | | 著者 | Yosaatmadja, Y, Paik, W.-K, Smaill, J.B, Squire, C.J. | | 登録日 | 2017-02-09 | | 公開日 | 2017-05-31 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | 2-Oxo-3, 4-dihydropyrimido[4, 5-d]pyrimidinyl derivatives as new irreversible pan fibroblast growth factor receptor (FGFR) inhibitors.
Eur J Med Chem, 135, 2017
|
|
5U5O
 | |
3DA8
 | | Crystal structure of PurN from Mycobacterium tuberculosis | | 分子名称: | BETA-MERCAPTOETHANOL, IODIDE ION, MAGNESIUM ION, ... | | 著者 | Zhang, Z, Squire, C.J, Baker, E.N. | | 登録日 | 2008-05-28 | | 公開日 | 2009-05-12 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Structures of glycinamide ribonucleotide transformylase (PurN) from Mycobacterium tuberculosis reveal a novel dimer with relevance to drug discovery.
J.Mol.Biol., 389, 2009
|
|
3DCJ
 | | Crystal structure of glycinamide formyltransferase (PurN) from Mycobacterium tuberculosis in complex with 5-methyl-5,6,7,8-tetrahydrofolic acid derivative | | 分子名称: | CHLORIDE ION, MAGNESIUM ION, N-[4-({[(6S)-2-AMINO-4-HYDROXY-5-METHYL-5,6,7,8-TETRAHYDROPTERIDIN-6-YL]METHYL}AMINO)BENZOYL]-L-GLUTAMIC ACID, ... | | 著者 | Zhang, Z, Squire, C.J, Baker, E.N. | | 登録日 | 2008-06-03 | | 公開日 | 2009-05-12 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structures of glycinamide ribonucleotide transformylase (PurN) from Mycobacterium tuberculosis reveal a novel dimer with relevance to drug discovery.
J.Mol.Biol., 389, 2009
|
|
3D98
 | |
6ANN
 | |
6ANM
 | |
6C19
 | | FGFR1 kinase complex with inhibitor SN36985 | | 分子名称: | 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{(3S)-1-[(2E)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl}-7-(methylamino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one, Fibroblast growth factor receptor 1, SULFATE ION | | 著者 | Yosaatmadja, Y, Smaill, J.B, Squire, C.J. | | 登録日 | 2018-01-04 | | 公開日 | 2019-01-16 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | | 主引用文献 | Understanding the structural requirements for covalent inhibition of FGFR1-3
To Be Published
|
|
6C1O
 | | FGFR1 kinase domain complexed with FIIN-1 | | 分子名称: | Fibroblast growth factor receptor 1, N-(3-{[3-(2,6-dichloro-3,5-dimethoxyphenyl)-7-{[4-(diethylamino)butyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl}phenyl)prop-2-enamide, SULFATE ION | | 著者 | Kalyukina, M, Yosaatmadja, Y, Smaill, J.B, Squire, C.J. | | 登録日 | 2018-01-05 | | 公開日 | 2019-01-16 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | | 主引用文献 | A new class of FGFR1 inhibitors
To Be Published
|
|
