6C19

FGFR1 kinase complex with inhibitor SN36985

Summary for 6C19

Related6C18
DescriptorFibroblast growth factor receptor 1, 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{(3S)-1-[(2E)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl}-7-(methylamino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one, SULFATE ION, ... (4 entities in total)
Functional Keywordskinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight71932.22
Authors
Yosaatmadja, Y.,Smaill, J.B.,Squire, C.J. (deposition date: 2018-01-04, release date: 2019-01-16)
Primary citation
Yosaatmadja, Y.,Squire, C.J.,Patterson, A.V.,Smaill, J.B.
Understanding the structural requirements for covalent inhibition of FGFR1-3
To Be Published,
Experimental method
X-RAY DIFFRACTION (2.12 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2433 0.2% 0.7% 4.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6c19
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Molmil generated image of 6c19
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Molmil generated image of 6c19
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More Biological unit images

Molmil generated image of 6c19
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Molmil generated image of 6c19
rotated about x axis by 90°
Molmil generated image of 6c19
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (6c19.pdb1.gz [92.09 KB])
Coordinate files for Biological unit (6c19.pdb2.gz [86.81 KB])