6C18
FGFR1 kinase complex with inhibitor SN37115
Summary for 6C18
Entry DOI | 10.2210/pdb6c18/pdb |
Related | 5UOK 5UOM 5UON |
Descriptor | Fibroblast growth factor receptor 1, 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{(3S)-1-[(2E)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl}-7-[(propan-2-yl)amino]-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one, SULFATE ION, ... (4 entities in total) |
Functional Keywords | kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 71988.32 |
Authors | Yosaatmadja, Y.,Smaill, J.B.,Squire, C.J. (deposition date: 2018-01-04, release date: 2019-01-16, Last modification date: 2023-10-04) |
Primary citation | Yosaatmadja, Y.,Squire, C.J.,Patterson, A.V.,Smaill, J.B. Understanding the structural requirements for covalent inhibition of FGFR1-3 To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
Download full validation report