6C18
FGFR1 kinase complex with inhibitor SN37115
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Fibroblast growth factor receptor 1 | polymer | 311 | 35353.6 | 2 | UniProt (P11362) Pfam (PF07714) | Homo sapiens (Human) | FGFR-1,Basic fibroblast growth factor receptor 1,bFGF-R-1,Fms-like tyrosine kinase 2,FLT-2,N-sam,Proto-oncogene c-Fgr |
| 2 | C, E (A, B) | 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{(3S)-1-[(2E)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl}-7-[(propan-2-yl)amino]-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one | non-polymer | 592.5 | 2 | Chemie (YY5) | |||
| 3 | D (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 17 | Chemie (HOH) |
Sequence modifications
A, B: 459 - 765 (UniProt: P11362)
| PDB | External Database | Details |
|---|---|---|
| Gly 455 | - | expression tag |
| Ala 456 | - | expression tag |
| Met 457 | - | expression tag |
| Ser 458 | - | expression tag |
| Ala 488 | Cys 486 | engineered mutation |
| Ser 584 | Cys 582 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 70707.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1281.1 | |
| All* | Total formula weight | 71988.3 |
