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6C19

FGFR1 kinase complex with inhibitor SN36985

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0004713molecular_functionprotein tyrosine kinase activity
A0005007molecular_functionfibroblast growth factor receptor activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
B0004672molecular_functionprotein kinase activity
B0004713molecular_functionprotein tyrosine kinase activity
B0005007molecular_functionfibroblast growth factor receptor activity
B0005524molecular_functionATP binding
B0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues15
Detailsbinding site for residue YY7 A 801
ChainResidue
ALEU484
AALA564
AASN568
AGLU571
ALEU630
AALA640
AASP641
AVAL492
AALA512
ALYS514
AGLU531
AMET535
AVAL559
AVAL561
AGLU562

site_idAC2
Number of Residues3
Detailsbinding site for residue SO4 A 802
ChainResidue
AGLY539
ALYS540
ALYS618

site_idAC3
Number of Residues15
Detailsbinding site for residue YY7 B 801
ChainResidue
BLEU484
BVAL492
BALA512
BLYS514
BGLU531
BVAL559
BVAL561
BGLU562
BTYR563
BALA564
BASN568
BGLU571
BLEU630
BALA640
BASP641

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues31
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGAFGQVVlAeaigldkdkpnrvtk...VAVK
ChainResidueDetails
ALEU484-LYS514

site_idPS00109
Number of Residues13
DetailsPROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. CIHrDLAARNVLV
ChainResidueDetails
ACYS619-VAL631

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028, ECO:0000269|PubMed:19224897
ChainResidueDetails
AALA625
BALA625

site_idSWS_FT_FI2
Number of Residues12
DetailsBINDING:
ChainResidueDetails
AGLU486
BARG570
BVAL629
BGLY643
ALEU516
AALA564
AARG570
AVAL629
AGLY643
BGLU486
BLEU516
BALA564

site_idSWS_FT_FI3
Number of Residues6
DetailsMOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:16507368, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:8622701
ChainResidueDetails
ALEU465
ATYR585
APRO587
BLEU465
BTYR585
BPRO587

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:16507368, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:19665973, ECO:0000269|PubMed:8622701
ChainResidueDetails
ALYS655
ALYS656
BLYS655
BLYS656

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:8622701
ChainResidueDetails
AMET732
BMET732

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PDB entries from 2024-11-13

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